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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：A0A166XB12 New Search
6PDB entries
21Biological assembly
36chain/assembly records
Main Difference Dimensions in This Set
Different construct Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
7WKU Structure of PDCoV Mpro in complex with an inhibitor Deposited 2022-01-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2509–2815（307 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；0.1M sodium citrate (pH 5.1), 4% (w/v) polyethylene glycol 6000
Resolution 2.60 Å R-free 0.241
7WKU Structure of PDCoV Mpro in complex with an inhibitor Deposited 2022-01-11 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2509–2815（307 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；0.1M sodium citrate (pH 5.1), 4% (w/v) polyethylene glycol 6000
Resolution 2.60 Å R-free 0.241
7WKU Structure of PDCoV Mpro in complex with an inhibitor Deposited 2022-01-11 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2509–2815（307 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；0.1M sodium citrate (pH 5.1), 4% (w/v) polyethylene glycol 6000
Resolution 2.60 Å R-free 0.241
7WKU Structure of PDCoV Mpro in complex with an inhibitor Deposited 2022-01-11 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 2509–2815（307 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；0.1M sodium citrate (pH 5.1), 4% (w/v) polyethylene glycol 6000
Resolution 2.60 Å R-free 0.241
7WKU Structure of PDCoV Mpro in complex with an inhibitor Deposited 2022-01-11 Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 2509–2815（307 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；0.1M sodium citrate (pH 5.1), 4% (w/v) polyethylene glycol 6000
Resolution 2.60 Å R-free 0.241
7WKU Structure of PDCoV Mpro in complex with an inhibitor Deposited 2022-01-11 Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 2509–2815（307 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；291 K；0.1M sodium citrate (pH 5.1), 4% (w/v) polyethylene glycol 6000
Resolution 2.60 Å R-free 0.241
9UOS Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 8 Deposited 2025-04-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2509–2809（301 aa）
Chain D 2509–2809（301 aa）
Not recorded A1EPZ (2~{S})-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.73 Å R-free 0.260
9UOS Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 8 Deposited 2025-04-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2509–2809（301 aa）
Chain E 2509–2809（301 aa）
Not recorded A1EPZ (2~{S})-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.73 Å R-free 0.260
9UOS Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 8 Deposited 2025-04-26 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2509–2809（301 aa）
Chain F 2509–2809（301 aa）
Not recorded A1EPZ (2~{S})-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.73 Å R-free 0.260
9X7D Crystal structure of PDCoV 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2509–2809（301 aa）
Chain E 2509–2809（301 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.28 Å R-free 0.249
9X7D Crystal structure of PDCoV 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 2509–2809（301 aa）
Chain D 2509–2809（301 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.28 Å R-free 0.249
9X7D Crystal structure of PDCoV 3CL protease (3CLpro) in complex with nirmatrelvir Deposited 2025-10-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2509–2809（301 aa）
Chain F 2509–2809（301 aa）
Not recorded 4WI (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.28 Å R-free 0.249
9X7F Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 1 Deposited 2025-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2509–2809（301 aa）
Chain B 2509–2809（301 aa）
Not recorded A1D7G (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.64 Å R-free 0.244
9X7F Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 1 Deposited 2025-10-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2509–2809（301 aa）
Chain D 2509–2809（301 aa）
Not recorded A1D7G (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.64 Å R-free 0.244
9X7F Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 1 Deposited 2025-10-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 2509–2809（301 aa）
Chain F 2509–2809（301 aa）
Not recorded A1D7G (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.64 Å R-free 0.244
9X7G Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2509–2809（301 aa）
Chain B 2509–2809（301 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.57 Å R-free 0.258
9X7G Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2509–2809（301 aa）
Chain D 2509–2809（301 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.57 Å R-free 0.258
9X7G Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 3 Deposited 2025-10-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 2509–2809（301 aa）
Chain F 2509–2809（301 aa）
Not recorded A1D7N (1~{R},2~{S},5~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3-[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.57 Å R-free 0.258
9X7H Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 6 Deposited 2025-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2509–2809（301 aa）
Chain B 2509–2809（301 aa）
Not recorded A1D7M (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.56 Å R-free 0.244
9X7H Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 6 Deposited 2025-10-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 2509–2809（301 aa）
Chain D 2509–2809（301 aa）
Not recorded A1D7M (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.56 Å R-free 0.244
9X7H Crystal structure of PDCoV 3CL protease (3CLpro) in complex with compound 6 Deposited 2025-10-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 2509–2809（301 aa）
Chain F 2509–2809（301 aa）
Not recorded A1D7M (2~{S})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(2~{S})-3,3-dimethyl-2-(methylsulfonylamino)butanoyl]amino]-4-methyl-pentanamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5-2% PEG6000, 100 mM sodium citrate, pH 4.6-5.25
Resolution 2.56 Å R-free 0.244

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.