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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：E2JF22 New Search
14PDB entries
14Biological assembly
43chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
11YE Curved structure of mPiezo1 in plasma membrane vesicles Deposited 2026-03-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 1–2547（2547 aa）
Chain D 1–2547（2547 aa）
Chain E 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
11ZC Flat structure of mPiezo1 in plasma membrane vesicles Deposited 2026-03-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Chain E 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.00 Å
3JAC Cryo-EM study of a channel Deposited 2015-06-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1959–2547（589 aa）
Chain B 1959–2547（589 aa）
Chain C 1959–2547（589 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2；25 mM NaPIPES, 140 mM NaCl, 2 mM DTT and 0.026% (w/v) C12E10
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.80 Å
4RAX A regulatory domain of an ion channel Deposited 2014-09-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2214–2457（244 aa） Fragment：UNP residues 2214-2457
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；0.2M Magnesium chloride, 0.1M Hepes pH 7.5, 25% w/w PEG3350, VAPOR DIFFUSION, SITTING DROP, temperature 291K
Resolution 1.45 Å R-free 0.176
5Z10 Structure of the mechanosensitive Piezo1 channel Deposited 2017-12-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain B 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE；After a 15 sec waiting time, the grids were blotted for 3.5 sec and plunged into liquid ethane
Resolution 3.97 Å
6B3R Structure of the mechanosensitive channel Piezo1 Deposited 2017-09-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Chain E 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；blot for 1 second with -1 force before plunging
Resolution 3.80 Å
6BPZ Structure of the mechanically activated ion channel Piezo1 Deposited 2017-11-27 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1137–1597（461 aa）
Chain A 1657–2547（891 aa）
Chain B 1137–1597（461 aa）
Chain B 1657–2547（891 aa）
Chain C 1137–1597（461 aa）
Chain C 1657–2547（891 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6LQI Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1 Deposited 2020-01-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain B 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.50 Å
7WLT the Curved Structure of mPIEZO1 in Lipid Bilayer Deposited 2022-01-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Chain E 1–2547（2547 aa）
Not recorded PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 3 P5S O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.46 Å
7WLU The Flattened Structure of mPIEZO1 in Lipid Bilayer Deposited 2022-01-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Chain E 1–2547（2547 aa）
Not recorded PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.81 Å
8IMZ Cryo-EM structure of mouse Piezo1-MDFIC complex (composite map) Deposited 2023-03-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain B 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.9
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
8IXN Curved structure of mPIEZO1-S2472E Deposited 2023-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Chain D 1–2547（2547 aa）
Mutation：S2472E Mutation：S2472E Mutation：S2472E PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 3 P5S O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.3
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.07 Å
8IXO Intermediate structure of mPIEZO1-S2472E Deposited 2023-04-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain B 1–2547（2547 aa）
Chain F 1–2547（2547 aa）
Mutation：S2472E Mutation：S2472E Mutation：S2472E PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 6 P5S O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.3
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
9VED The cryo-EM structure of mouse Piezo1-MDFI complex Deposited 2025-06-09 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–2547（2547 aa）
Chain B 1–2547（2547 aa）
Chain C 1–2547（2547 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.9
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.63 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.