Current Protein Identity：O09893
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1C6X ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. Deposited 1999-12-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–99（99 aa）
Chain B
1–99（99 aa）
|
Not recorded | 3IN N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
crystals obtained by co-crystallization at ph 5.2, using 0.6M NaCl as precipitating agent in 0.1M sodium acetate buffer. protein was at 5.5 mg/ml concentration
|
Resolution 2.50 Å R-free 0.300 |
| 1C6Y ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. Deposited 1999-12-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–99（99 aa）
Chain B
1–99（99 aa）
|
Not recorded | MK1 N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
THE CRYSTAL WAS PREPARED WITH CO CRYSTALLIZATION METHOD.
9X MUTANT PROTEASE HAS NINE POINT MUTATIONS COMPARED TO
WILD TYPE: L10V,K20M,L24I,S37D,M46I,I54V,L63P,A71V,V82T
THERE IS ONE PROTEASE DIMER IN AN ASYMMETRICAL UNIT. THE
TWO MOLECULES ARE LABELED AS CHAIN A AND CHAIN B. THERE
IS ONE L-735,524 INHIBITOR MOLECULE LABELED AS MK1.
|
Resolution 2.50 Å R-free 0.310 |
| 1C6Z ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. Deposited 1999-12-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–99（99 aa）
Chain B
1–99（99 aa）
|
Not recorded | ROC (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
CRYSTALS OBTAINED BY CO-CRYSTALLIZATION AT PH 5.2, USING 0.6M NaCl AS PRECIPITATING AGENT IN 0.1M SODIUM ACETATE BUFFER. PROTEIN WAS AT 5.5 MG/ML CONCENTRATION.
|
Resolution 2.50 Å R-free 0.290 |