Current Protein Identity：O35718
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2BBU solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor Deposited 2005-10-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
22–185（164 aa）
Fragment：KIR/ESS/SH2 DOMAIN/PEST MOTIF
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；298 K；Ionic strength (raw mmCIF value) 50mM；Pressure 1
NMR sample composition
0.3mM U-15N-13C-SOCS3/0.3mM phophopeptide, 20mM Na-phosphate, pH 6.7, 2mM DTT, 1mM edta, 50mM glutamate, 50mM Arginine, 5% D2O | 95% H20, 5% D2O
NMR sample composition
0.3mM U-15N-SOCS3/0.3mM phophopeptide, 20mM Na-phosphate, pH 6.7, 2mM DTT, 1mM edta, 50mM glutamate, 50mM Arginine, 5% D2O | 95% H20, 5% D2O
NMR sample composition
0.3mM U-13C-SOCS3/0.3mM phophopeptide, 20mM Na-phosphate, pH 6.7, 2mM DTT, 1mM edta, 50mM glutamate, 50mM Arginine, 5% D2O | 95% H20, 5% D2O
NMR sample composition
0.3mM SOCS3/0.3mM phophopeptide, 20mM Na-phosphate, pH 6.7, 2mM DTT, 1mM edta, 50mM glutamate, 50mM Arginine, 5% D2O | 95% H20, 5% D2O
NMR sample composition
0.3mM SOCS3/0.3mM phophopeptide, 20mM Na-phosphate, pH 6.7, 2mM DTT, 1mM edta, 50mM glutamate, 50mM Arginine, 5% D2O | 100% D2O
|
Resolution not provided |
| 2HMH Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. Deposited 2006-07-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
15–130（116 aa）
Chain A
154–185（32 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；297 K；30% PEG8000, 0.1 M Sodium Cacodylate, 0.2 M Sodium Acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K, pH 6.50
|
Resolution 2.00 Å R-free 0.291 |
| 2JZ3 SOCS box elonginBC ternary complex Deposited 2007-12-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
186–225（40 aa）
Fragment：SOCS box, UNP residues 186-225
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；310 K；Ionic strength (raw mmCIF value) 0.05；Pressure ambient
NMR sample composition
1mM [U-100% 13C; U-100% 15N] socs box; 1mM elonginB; 1mM elonginC; 50mM potassium chloride; 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 4GL9 Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain Deposited 2012-08-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain E
38–128（91 aa）
Fragment：chimeric fusion of Intracellular domain (unp residues 22-128 and 163-185)
|
Not recorded | IZA 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；298 K；0.33M di-potassium hydrogen phosphate, 1.67M sodium dihydrogen phosphate, 0.1M phosphate-citrate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.90 Å R-free 0.281 |
| 4GL9 Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain Deposited 2012-08-14 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain H
38–128（91 aa）
Fragment：chimeric fusion of Intracellular domain (unp residues 22-128 and 163-185)
|
Not recorded | IZA 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE × 1 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；298 K；0.33M di-potassium hydrogen phosphate, 1.67M sodium dihydrogen phosphate, 0.1M phosphate-citrate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.90 Å R-free 0.281 |
| 4GL9 Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain Deposited 2012-08-14 | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain G
38–128（91 aa）
Fragment：chimeric fusion of Intracellular domain (unp residues 22-128 and 163-185)
|
Not recorded | IZA 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；298 K；0.33M di-potassium hydrogen phosphate, 1.67M sodium dihydrogen phosphate, 0.1M phosphate-citrate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.90 Å R-free 0.281 |
| 4GL9 Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain Deposited 2012-08-14 | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain F
38–128（91 aa）
Fragment：chimeric fusion of Intracellular domain (unp residues 22-128 and 163-185)
|
Not recorded | IZA 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；298 K；0.33M di-potassium hydrogen phosphate, 1.67M sodium dihydrogen phosphate, 0.1M phosphate-citrate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.90 Å R-free 0.281 |