Current Protein Identity：O43464
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1LCY Crystal Structure of the Mitochondrial Serine Protease HtrA2 Deposited 2002-04-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：S173A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；295 K；lithium sulfate, sodium chloride, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.00 Å R-free 0.274 |
| 1LCY Crystal Structure of the Mitochondrial Serine Protease HtrA2 Deposited 2002-04-07 | Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：S173A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；295 K；lithium sulfate, sodium chloride, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.00 Å R-free 0.274 |
| 2PZD Crystal Structure of the HtrA2/Omi PDZ Domain Bound to a Phage-Derived Ligand (WTMFWV) Deposited 2007-05-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
359–458（100 aa）
Chain B
359–458（100 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.6；292 K；0.1 M sodium citrate, 1.0 M monoammonium dihydrogen phosphate, pH 5.6, VAPOR DIFFUSION, temperature 292K
|
Resolution 2.75 Å R-free 0.254 |
| 5FHT HtrA2 protease mutant V226K Deposited 2015-12-22 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
134–458（325 aa）
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 CL CHLORIDE ION × 1 K POTASSIUM ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；MES, NaCl, KH2PO4, NaH2PO4
|
Resolution 1.95 Å R-free 0.228 |
| 5M3N HTRA2 wild-type structure Deposited 2016-10-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6；293 K；Crystals were grown using the sitting drop vapor-diffusion method by mixing equal volumes of protein (10-15 mg/mL) and reservoir solution containing 0.1 M MES pH 6.0, 1 M LiCl, and 15-20% (w/v) PEG-6000
|
Resolution 1.65 Å R-free 0.175 |
| 5M3O HTRA2 A141S mutant structure Deposited 2016-10-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：Mutation A141S | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；0.1 M MES pH 6.0, 1 M LiCl, and 15-20% (w/v) PEG-6000
|
Resolution 1.70 Å R-free 0.200 |
| 5TNY HTRA2 G399S mutant Deposited 2016-10-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：G399S | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.1 M MES pH 6.0, 1 M LiCl, and 15-20% (w/v) PEG-6000
|
Resolution 1.70 Å R-free 0.187 |
| 5TNZ HtrA2 S142D mutant Deposited 2016-10-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
Fragment：UNP residues 134-458
|
Mutation：S142D | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 NA SODIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；0.1 M MES pH 6.0, 1 M LiCl, and 15-20% (w/v) PEG-6000
|
Resolution 1.75 Å R-free 0.172 |
| 5TO0 HTRA2 S276C mutant Deposited 2016-10-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：Mutation S276C | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；0.1 M MES pH 6.0, 1 M LiCl, and 15-20% (w/v) PEG-6000
|
Resolution 1.90 Å R-free 0.177 |
| 5TO1 HtrA2 exposed (L266R, F303A) mutant Deposited 2016-10-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：L266R and F303A | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；0.1 M MES pH 6.0, 1 M LiCl, and 15-20% (w/v) PEG-6000
|
Resolution 1.69 Å R-free 0.198 |
| 5WYN HtrA2 Pathogenic Mutant Deposited 2017-01-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
134–458（325 aa）
|
Mutation：S143C,Y295W | CL CHLORIDE ION × 18 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；Sodium phosphate monobasic monohydrate
Potassium phosphate monobasic
Sodium chloride
|
Resolution 2.05 Å R-free 0.185 |
| 7VGE Structure of the PDZ deleted variant of HtrA2 protease (S306A) Deposited 2021-09-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
140–342（203 aa）
Chain B
140–342（203 aa）
Chain C
140–342（203 aa）
|
Mutation：S306A Mutation：S306A Mutation：S306A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；290 K；0.5 M Sodium acetate trihydrate pH 6.0, 2.0 M Sodium formate, 3% glycerol
|
Resolution 4.00 Å R-free 0.336 |
| 7VGE Structure of the PDZ deleted variant of HtrA2 protease (S306A) Deposited 2021-09-15 | Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
140–341（202 aa）
Chain E
140–340（201 aa）
Chain F
140–341（202 aa）
|
Mutation：S306A Mutation：S306A Mutation：S306A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；290 K；0.5 M Sodium acetate trihydrate pH 6.0, 2.0 M Sodium formate, 3% glycerol
|
Resolution 4.00 Å R-free 0.336 |
| 8AUK Cryo-EM structure of human BIRC6 in complex with HTRA2. Deposited 2022-08-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain C
134–458（325 aa）
Chain D
134–458（325 aa）
Chain E
134–458（325 aa）
|
Mutation：S306A Mutation：S306A Mutation：S306A | ZN ZINC ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 6.20 Å |
| 8E2K Cryo-EM structure of BIRC6/HtrA2-S306A Deposited 2022-08-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain X
134–458（325 aa）
Chain Y
134–458（325 aa）
Chain Z
134–458（325 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |