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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O75762 New Search
17PDB entries
17Biological assembly
65chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
3J9P Structure of the TRPA1 ion channel determined by electron cryo-microscopy Deposited 2015-02-14 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1119（1118 aa） Fragment：SEE REMARK 999
Chain B 2–1119（1118 aa） Fragment：SEE REMARK 999
Chain C 2–1119（1118 aa） Fragment：SEE REMARK 999
Chain D 2–1119（1118 aa） Fragment：SEE REMARK 999
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM HEPES, 150 mM NaCl, 1 mM DTT, 1 mM IP6；pH 8；20 mM HEPES, 150 mM NaCl, 1 mM DTT, 1 mM IP6
cryo-EM vitrification conditions Blot for 7 seconds before plunging.；120 K；Cryogen ETHANE；Blot for 7 seconds before plunging into liquid ethane (FEI VITROBOT MARK I).
Resolution 4.24 Å
6HC8 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPA1 (313-339) Deposited 2018-08-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain E 313–339（27 aa）
Not recorded ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 2 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M Hepes pH = 7.5, 1.6 M ammonium sulfate, 6% PEG400
Resolution 1.90 Å R-free 0.189
6PQO Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 Deposited 2019-07-09 Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1119（1118 aa）
Chain B 2–1119（1118 aa）
Chain C 2–1119（1118 aa）
Chain D 2–1119（1118 aa）
Not recorded JT0 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide × 4 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 8 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
6PQP Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC Deposited 2019-07-09 Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1119（1118 aa）
Chain B 2–1119（1118 aa）
Chain C 2–1119（1118 aa）
Chain D 2–1119（1118 aa）
Not recorded 9BE N-benzylthioformamide × 4 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 20 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.06 Å
6PQQ Cryo-EM structure of human TRPA1 C621S mutant in the apo state Deposited 2019-07-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1119（1118 aa）
Chain B 2–1119（1118 aa）
Chain C 2–1119（1118 aa）
Chain D 2–1119（1118 aa）
Mutation：C621S Mutation：C621S Mutation：C621S Mutation：C621S LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 8 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.81 Å
6V9V Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG Deposited 2019-12-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Mutation：D966E Mutation：D966E Mutation：D966E Mutation：D966E QT4 ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide × 4 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
6V9W Structure of TRPA1 (ligand-free) with bound calcium, LMNG Deposited 2019-12-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Mutation：D966E Mutation：D966E Mutation：D966E Mutation：D966E CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6V9X Structure of TRPA1 modified by iodoacetamide, PMAL-C8 Deposited 2019-12-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Mutation：D966E Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：D966E Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：D966E Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：D966E Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
6V9Y Structure of TRPA1 bound with A-967079, PMAL-C8 Deposited 2019-12-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Mutation：D966E Mutation：D966E Mutation：D966E Mutation：D966E No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
6WJ5 Structure of human TRPA1 in complex with inhibitor GDC-0334 Deposited 2020-04-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 448–1078（631 aa）
Chain B 448–1078（631 aa）
Chain C 448–1078（631 aa）
Chain D 448–1078（631 aa）
Not recorded LXY (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.2
cryo-EM vitrification conditions Cryogen ETHANE；2 x 4s blot time
Resolution 3.60 Å
6X2J Structure of human TRPA1 in complex with agonist GNE551 Deposited 2020-05-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 448–1078（631 aa）
Chain B 448–1078（631 aa）
Chain C 448–1078（631 aa）
Chain D 448–1078（631 aa）
Not recorded ULJ 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.2
cryo-EM vitrification conditions Cryogen ETHANE；Triple blot. Put blot in vitroblot Apply 3.5ul to grid, wait 30sec, blot manually Apply 3.5ul to grid, wait 30sec, blot manually, apply final 3.5ul, final blot by vitrobot (3.5s)
Resolution 3.00 Å
7JUP Structure of human TRPA1 in complex with antagonist compound 21 Deposited 2020-08-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 448–1078（631 aa）
Chain B 448–1078（631 aa）
Chain C 448–1078（631 aa）
Chain D 448–1078（631 aa）
Not recorded VKM 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8.2
cryo-EM vitrification conditions Cryogen ETHANE；Triple blot. Put blot in vitroblot Apply 3.5ul to grid, wait 30sec, blot manually Apply 3.5ul to grid, wait 30sec, blot manually, apply final 3.5ul, final blot by vitrobot (3.5s)
Resolution 3.05 Å
7OR0 Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2 Deposited 2021-06-04 Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Not recorded 0IG ~{N}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 8 CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 IHP INOSITOL HEXAKISPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.64 Å
7OR1 Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1 Deposited 2021-06-04 Assembly 1 Other combination Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Not recorded 0IG ~{N}-[4-[4-[(azanylidene-$l^{4}-azanylidene)amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 8 CA CALCIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 IHP INOSITOL HEXAKISPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.64 Å
9M8N Cryo-EM structure of the human TRPA1 ion channel in complex with crotalphine. Deposited 2025-03-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.81 Å
9M8S Cryo-EM structure of the human TRPA1 ion channel in ligand-free state. Deposited 2025-03-12 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–1119（1119 aa）
Chain B 1–1119（1119 aa）
Chain C 1–1119（1119 aa）
Chain D 1–1119（1119 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9MOE Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318 Deposited 2024-12-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–1119（1118 aa）
Chain B 2–1119（1118 aa）
Chain D 2–1119（1118 aa）
Chain E 2–1119（1118 aa）
Not recorded A1BNO (2S)-2-{3-methyl-1-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl}-N-{6-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-2-yl}propanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM HEPES, pH 8, 150 mM NaCl, 0.5 mM TCEP and 0.01% LMNG
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.