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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P00394 New Search
5PDB entries
9Biological assembly
21chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1B5T ESCHERICHIA COLI METHYLENETETRAHYDROFOLATE REDUCTASE Deposited 1999-01-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 21–295（275 aa）
Chain B 21–295（275 aa）
Chain C 21–295（275 aa）
Not recorded HG MERCURY (II) ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；pH 6.0
Resolution 2.50 Å R-free 0.263
1ZP3 E. coli Methylenetetrahydrofolate Reductase (oxidized) Deposited 2005-05-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–296（296 aa）
Chain C 1–296（296 aa）
Not recorded SO4 SULFATE ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K
Resolution 1.85 Å R-free 0.237
1ZP3 E. coli Methylenetetrahydrofolate Reductase (oxidized) Deposited 2005-05-16 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–296（296 aa）
Chain C 1–296（296 aa）
Not recorded SO4 SULFATE ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K
Resolution 1.85 Å R-free 0.237
1ZP3 E. coli Methylenetetrahydrofolate Reductase (oxidized) Deposited 2005-05-16 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–296（296 aa）
Not recorded SO4 SULFATE ION × 2 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K
Resolution 1.85 Å R-free 0.237
1ZP4 Glu28Gln mutant of E. coli Methylenetetrahydrofolate Reductase (oxidized) complex with Methyltetrahydrofolate Deposited 2005-05-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–296（296 aa）
Chain B 1–296（296 aa）
Chain C 1–296（296 aa）
Mutation：E28Q Mutation：E28Q Mutation：E28Q SO4 SULFATE ION × 2 C2F 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID × 4 FAD FLAVIN-ADENINE DINUCLEOTIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K
Resolution 1.85 Å R-free 0.231
1ZPT Escherichia coli Methylenetetrahydrofolate Reductase (reduced) complexed with NADH, pH 7.25 Deposited 2005-05-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–296（296 aa）
Chain B 1–296（296 aa）
Chain C 1–296（296 aa）
Not recorded SO4 SULFATE ION × 5 FAD FLAVIN-ADENINE DINUCLEOTIDE × 4 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.25；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, pH 7.25, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K
Resolution 1.95 Å R-free 0.246
1ZRQ Escherichia coli Methylenetetrahydrofolate Reductase (reduced) complexed with NADH, pH 6.0 Deposited 2005-05-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–296（296 aa）
Chain C 1–296（296 aa）
Not recorded SO4 SULFATE ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K, pH 6.00
Resolution 2.20 Å R-free 0.252
1ZRQ Escherichia coli Methylenetetrahydrofolate Reductase (reduced) complexed with NADH, pH 6.0 Deposited 2005-05-19 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–296（296 aa）
Chain C 1–296（296 aa）
Not recorded SO4 SULFATE ION × 3 FAD FLAVIN-ADENINE DINUCLEOTIDE × 2 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K, pH 6.00
Resolution 2.20 Å R-free 0.252
1ZRQ Escherichia coli Methylenetetrahydrofolate Reductase (reduced) complexed with NADH, pH 6.0 Deposited 2005-05-19 Assembly 3 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–296（296 aa）
Chain B 1–296（296 aa）
Chain C 1–296（296 aa）
Not recorded SO4 SULFATE ION × 8 FAD FLAVIN-ADENINE DINUCLEOTIDE × 6 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 6 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；295 K；PEG 4000, LITHIUM SULFATE, SODIUM CACODYLATE, ETHANOL, MESO-ERYTHRITOL, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K, pH 6.00
Resolution 2.20 Å R-free 0.252

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.