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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P00738 New Search
15PDB entries
17Biological assembly
24chain/assembly records
Main Difference Dimensions in This Set
Different construct Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: Decameric（10） Consistent with protein count
Chain C 92–406（315 aa）
Chain H 92–406（315 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Assembly 2 Other combination Heteromer；Protein × 10 PDB declaration: Decameric（10） Consistent with protein count
Chain M 92–406（315 aa）
Chain R 92–406（315 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 Assembly 3 Other combination Heteromer；Protein × 10 PDB declaration: Decameric（10） Consistent with protein count
Chain 2 92–406（315 aa）
Chain W 92–406（315 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
Resolution 3.10 Å R-free 0.271
4X0L Human haptoglobin-haemoglobin complex Deposited 2014-11-21 Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 148–406（259 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 CAC CACODYLATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M NaCl, 0.1 M sodium cacodylate pH 6.5 and 2 M ammonium sulphate
Resolution 2.05 Å R-free 0.224
5HU6 Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin Deposited 2016-01-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 148–406（259 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；12.5% v/v MPD, 0.03 M NaBr, 0.03M NaI, 0.03M NaF, 0.1 M MES/imidazole pH 6.5, 12.5% w/v PEG 1000, 12.5% w/v PEG 3350
Resolution 2.90 Å R-free 0.226
6TB2 Structure of human haptoglobin-hemoglobin bound to S. aureus IsdH Deposited 2019-10-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain C 148–406（259 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M sodium citrate tribasic dihydrate, 20 % w/v PEG 3350
Resolution 2.90 Å R-free 0.270
8XMP Structure of CD163 in complex with Hb-Hp Deposited 2023-12-27 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain 2 1–347（347 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 10 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.11 Å
8XMQ Structure of dimeric CD163 in complex with Hb-Hp Deposited 2023-12-27 Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain 2 1–347（347 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 CA CALCIUM ION × 12 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å
8XMW Local refinement of Hb-Hp bind to CD163 Deposited 2023-12-28 Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain 2 1–347（347 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.94 Å
9FHB Cryo-EM structure of human CD163 SRCR2-4 in complex with haptoglobin-hemoglobin Deposited 2024-05-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 1–406（406 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.87 Å
9FMU Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain C 1–347（347 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 CA CALCIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.46 Å
9FNM Structure of human haptoglobin Deposited 2024-06-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 19–101（83 aa）
Chain B 162–406（245 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 4.5；277 K；6% 2-propanol 0.1 M sodium acetate trihydrate 26% PEG MME 550
Resolution 2.52 Å R-free 0.227
9FNO Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain C 19–101（83 aa）
Chain D 162–406（245 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.20 Å
9HEJ Dimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain F 1–347（347 aa）
Chain G 1–347（347 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 9 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.82 Å
9HEK Trimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain F 1–347（347 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 CA CALCIUM ION × 19 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.15 Å
9NB6 Cryo-EM structure of the CD163/Hp(1-1)Hb complex Deposited 2025-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain F 1–347（347 aa）
Chain G 1–347（347 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9NB8 Cryo-EM structure of the CD163/HpSPHb complex Deposited 2025-02-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain F 147–406（260 aa）
Not recorded CA CALCIUM ION × 21 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.