Current Protein Identity：P04273
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1B10 SOLUTION NMR STRUCTURE OF RECOMBINANT SYRIAN HAMSTER PRION PROTEIN RPRP(90-231) , 25 STRUCTURES Deposited 1998-11-25 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
90–231（142 aa）
Fragment：90 - 231
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5.2；303 K；Pressure 1
|
Resolution not provided |
| 2KKG NMR structure of the octarepeat region of prion protein bound to pentosan polysulfate Deposited 2009-06-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
23–106（84 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5；298 K；Pressure ambient
NMR sample composition
0.5 mM [U-15N] octarepeats-1, 5 % [U-2H] D2O-2, 20 % [U-2H] DMSO-3, 20 mM pentosan polysulfate-4, 10 mM sodium acetate-5, 75 % H2O-6, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition
0.5 mM [U-13C; U-15N] octarepeats-7, 5 % [U-2H] D2O-8, 20 % [U-2H] DMSO-9, 20 mM pentosan polysulfate-10, 10 mM sodium acetate-11, 75 % H2O-12, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition
0.5 mM [U-13C; U-15N] octarepeats-13, 80 % [U-2H] D2O-14, 20 % [U-2H] DMSO-15, 20 mM pentosan polysulfate-16, 10 mM sodium acetate-17, 100% D2O | 100% D2O
|
Resolution not provided |
| 2LH8 Syrian hamster prion protein with thiamine Deposited 2011-08-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
125–228（104 aa）
Fragment：UNP residues 125-228
|
Not recorded | VIB 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM × 1 | SOLUTION NMR |
NMR measurement conditions
pH 6.2；298 K；Ionic strength (raw mmCIF value) 0.02；Pressure ambient
NMR sample composition
0.3 mM [U-100% 15N] shPrP, 10 mM thiamine, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.5 mM shPrP, 12.5 mM thiamine, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.5 mM shPrP, 10 mM thiamine, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 3NVE MMHFGN segment 138-143 from Syrian Hamster prion Deposited 2010-07-08 | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count |
Chain A
138–143（6 aa）
Chain B
138–143（6 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.2 M Ammonium sulfate, 200 mM BisTris pH 7.5, vapor diffusion, hanging drop, temperature 298K
|
Resolution 1.70 Å R-free 0.269 |
| 4YXL Crystal structure of Syrian hamster prion protein complexed with POM1 FAB Deposited 2015-03-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
90–232（143 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；25% PEG3350, 0.1 M BIS-TRIS, 0.2 M lithium sulphate
|
Resolution 2.60 Å R-free 0.310 |
| 7LNA Infectious mammalian prion fibril (263K scrapie) Deposited 2021-02-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
90–231（142 aa）
Chain B
90–231（142 aa）
Chain C
90–231（142 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.14 Å |
| 7YAT CryoEM tetra protofilament structure of the hamster prion 108-144 fibril Deposited 2022-06-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count |
Chain A
119–143（25 aa）
Chain B
119–143（25 aa）
Chain C
119–143（25 aa）
Chain D
119–143（25 aa）
Chain E
119–143（25 aa）
Chain F
119–143（25 aa）
Chain G
119–143（25 aa）
Chain H
119–143（25 aa）
Chain I
119–143（25 aa）
Chain J
119–143（25 aa）
Chain K
119–143（25 aa）
Chain L
119–143（25 aa）
Chain M
119–143（25 aa）
Chain N
119–143（25 aa）
Chain O
119–143（25 aa）
Chain P
119–143（25 aa）
Chain Q
119–143（25 aa）
Chain R
119–143（25 aa）
Chain S
119–143（25 aa）
Chain T
119–143（25 aa）
Chain U
119–143（25 aa）
Chain V
119–143（25 aa）
Chain X
119–143（25 aa）
Chain Y
119–143（25 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 3.7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.20 Å |
| 8WZX Cryo-EM structure of the hamster prion 23-144 fibril at pH 3.7 Deposited 2023-11-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 20 PDB declaration: eicosameric（20） Consistent with protein count |
Chain A
23–144（122 aa）
Chain B
23–144（122 aa）
Chain C
23–144（122 aa）
Chain D
23–144（122 aa）
Chain E
23–144（122 aa）
Chain F
23–144（122 aa）
Chain G
23–144（122 aa）
Chain H
23–144（122 aa）
Chain I
23–144（122 aa）
Chain J
23–144（122 aa）
Chain K
23–144（122 aa）
Chain L
23–144（122 aa）
Chain M
23–144（122 aa）
Chain N
23–144（122 aa）
Chain O
23–144（122 aa）
Chain P
23–144（122 aa）
Chain Q
23–144（122 aa）
Chain R
23–144（122 aa）
Chain S
23–144（122 aa）
Chain T
23–144（122 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 3.7；20 mM NaOAc, 140 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.88 Å |