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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P06400 New Search
17PDB entries
28Biological assembly
41chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1AD6 DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR Deposited 1997-02-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 378–562（185 aa） Fragment：DOMAIN A
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；pH 6.0
Resolution 2.30 Å R-free 0.240
1GH6 RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN Deposited 2000-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 379–577（199 aa） Fragment：UNP residues 379-577 and 645-772
Chain B 645–772（128 aa） Fragment：UNP residues 379-577 and 645-772
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 3.20 Å R-free 0.314
1GUX RB POCKET BOUND TO E7 LXCXE MOTIF Deposited 1997-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 372–589（218 aa） Fragment：POCKET DOMAIN
Chain B 636–787（152 aa） Fragment：POCKET DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；3.5 M SODIUM FORMATE, 0.1M NA HEPES PH 7.5, 20 MIROMOLAR CDCL2
Resolution 1.85 Å R-free 0.289
1H25 CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein Deposited 2002-07-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 868–878（11 aa） Fragment：RESIDUES 869-878
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；0.8M KCL, 1.2M (NH4)2SO4, 40MM HEPES PH 7.0. PROTEIN CONCENTRATION = 10MG/ML
Resolution 2.50 Å R-free 0.266
1O9K Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide Deposited 2002-12-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 372–589（218 aa） Fragment：DOMAIN A, RESIDUES 372-589
Chain B 636–787（152 aa） Fragment：DOMAIN B, RESIDUES 636-787
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.8；pH 7.80
Resolution 2.60 Å R-free 0.285
1O9K Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide Deposited 2002-12-16 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 372–589（218 aa） Fragment：DOMAIN A, RESIDUES 372-589
Chain D 636–787（152 aa） Fragment：DOMAIN B, RESIDUES 636-787
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.8；pH 7.80
Resolution 2.60 Å R-free 0.285
1O9K Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide Deposited 2002-12-16 Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 372–589（218 aa） Fragment：DOMAIN A, RESIDUES 372-589
Chain F 636–787（152 aa） Fragment：DOMAIN B, RESIDUES 636-787
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.8；pH 7.80
Resolution 2.60 Å R-free 0.285
1O9K Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide Deposited 2002-12-16 Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain G 372–589（218 aa） Fragment：DOMAIN A, RESIDUES 372-589
Chain H 636–787（152 aa） Fragment：DOMAIN B, RESIDUES 636-787
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.8；pH 7.80
Resolution 2.60 Å R-free 0.285
1PJM Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex Deposited 2003-06-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 857–876（20 aa） Fragment：NLS (nuclear localization signal) bipartite peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；Sodium Citrate, DTT, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.50 Å R-free 0.239
2AZE Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer Deposited 2005-09-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 829–874（46 aa） Fragment：C-terminal core domain (residues 829-874)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；Sodium Citrate, Ammonium Sulfate, PEG 400, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.55 Å R-free 0.262
2AZE Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer Deposited 2005-09-10 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 829–874（46 aa） Fragment：C-terminal core domain (residues 829-874)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；Sodium Citrate, Ammonium Sulfate, PEG 400, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.55 Å R-free 0.262
2QDJ Crystal structure of the Retinoblastoma protein N-domain provides insight into tumor suppression, ligand interaction and holoprotein architecture Deposited 2007-06-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 52–355（304 aa） Fragment：N-terminal domain
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；0.2 M Na acetate, 25% (w/v) PEG 4000, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.00 Å R-free 0.276
2R7G Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain Deposited 2007-09-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 380–581（202 aa） Fragment：Pocket domain, deletion of residues 582-642
Chain A 643–787（145 aa） Fragment：Pocket domain, deletion of residues 582-642
Chain C 380–581（202 aa） Fragment：Pocket domain, deletion of residues 582-642
Chain C 643–787（145 aa） Fragment：Pocket domain, deletion of residues 582-642
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；293 K；15mM magnesium acetate tetrahydrate, 50mM sodium cacodylate trihydrate, pH 6.0 and 1.7M ammonium sulfate, VAPOR DIFFUSION, temperature 293K
Resolution 1.67 Å R-free 0.218
3N5U Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 Deposited 2010-05-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 870–882（13 aa） Fragment：UNP residues 870-882
Not recorded MN MANGANESE (II) ION × 4 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 7.5；298 K；100mM HEPES, 200mM MgCl2, 18% PEG 4000, pH 7.5, hanging drop, temperature 298K
Resolution 3.20 Å R-free 0.261
3N5U Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 Deposited 2010-05-25 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 870–882（13 aa） Fragment：UNP residues 870-882
Not recorded MN MANGANESE (II) ION × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 7.5；298 K；100mM HEPES, 200mM MgCl2, 18% PEG 4000, pH 7.5, hanging drop, temperature 298K
Resolution 3.20 Å R-free 0.261
3POM Crystal Structure of the Unliganded Retinoblastoma Protein Pocket Domain Deposited 2010-11-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 380–577（198 aa） Fragment：Pocket Domain, Domain A, UNP residues 380-577, Domain B, UNP residues 643-787
Chain A 643–783（141 aa） Fragment：Pocket Domain, Domain A, UNP residues 380-577, Domain B, UNP residues 643-787
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 10.6；277 K；100 mM CAPS, 10% PEG 3350, pH 10.6, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.50 Å R-free 0.262
3POM Crystal Structure of the Unliganded Retinoblastoma Protein Pocket Domain Deposited 2010-11-23 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 380–577（198 aa） Fragment：Pocket Domain, Domain A, UNP residues 380-577, Domain B, UNP residues 643-787
Chain B 643–783（141 aa） Fragment：Pocket Domain, Domain A, UNP residues 380-577, Domain B, UNP residues 643-787
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 10.6；277 K；100 mM CAPS, 10% PEG 3350, pH 10.6, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.50 Å R-free 0.262
4ELJ Crystal structure of the inactive retinoblastoma protein phosphorylated at T373 Deposited 2012-04-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 53–244（192 aa） Fragment：UNP residues 53-244, 268-582, 642-787
Chain A 268–582（315 aa） Fragment：UNP residues 53-244, 268-582, 642-787
Chain A 642–787（146 aa） Fragment：UNP residues 53-244, 268-582, 642-787
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277.15 K；100mM HEPES, 100mM Ammonium Fluoride, 16% PEG4K, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 2.70 Å R-free 0.266
4ELL Structure of the inactive retinoblastoma protein pocket domain Deposited 2012-04-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 380–787（408 aa） Fragment：POCKET DOMAIN, UNP residues 380-787
Mutation：S608E, L561F No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；277.15 K；100mM sodium citrate, 1mM LiCl, 18% PEG 8K., pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 1.98 Å R-free 0.238
4ELL Structure of the inactive retinoblastoma protein pocket domain Deposited 2012-04-10 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 380–787（408 aa） Fragment：POCKET DOMAIN, UNP residues 380-787
Mutation：S608E, L561F No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；277.15 K；100mM sodium citrate, 1mM LiCl, 18% PEG 8K., pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 1.98 Å R-free 0.238
9DGK The Retinoblastoma Protein with Mutation M704V Deposited 2024-09-02 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 380–793（414 aa）
Mutation：M704V, S608E, S612A, S780A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；18% PEG 8K, 0.1M sodium citrate, 0.1M succinate pH 5.5, 1M lithium chloride
Resolution 2.38 Å R-free 0.277
9DGK The Retinoblastoma Protein with Mutation M704V Deposited 2024-09-02 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 380–793（414 aa）
Mutation：M704V, S608E, S612A, S780A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；18% PEG 8K, 0.1M sodium citrate, 0.1M succinate pH 5.5, 1M lithium chloride
Resolution 2.38 Å R-free 0.277
9DHC The Retinoblastoma Protein with Mutation S751Y Deposited 2024-09-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 380–793（414 aa）
Mutation：S751Y, S608E, S612A, S780A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；18% PEG 8K, 0.1M sodium citrate, 0.1M succinate pH5.5, 1M lithium chloride
Resolution 2.32 Å R-free 0.263
9DHC The Retinoblastoma Protein with Mutation S751Y Deposited 2024-09-03 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 380–793（414 aa）
Mutation：S751Y, S608E, S612A, S780A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；18% PEG 8K, 0.1M sodium citrate, 0.1M succinate pH5.5, 1M lithium chloride
Resolution 2.32 Å R-free 0.263
9DHF The Retinoblastoma Protein with Mutation E554K Deposited 2024-09-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 380–793（414 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；18% PEG8K, 0.1M sodium citrate, 0.1M succinate pH 5.5, 1M lithium chloride
Resolution 2.26 Å R-free 0.265
9DHF The Retinoblastoma Protein with Mutation E554K Deposited 2024-09-03 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 380–793（414 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；18% PEG8K, 0.1M sodium citrate, 0.1M succinate pH 5.5, 1M lithium chloride
Resolution 2.26 Å R-free 0.265
9DHU The Retinoblastoma Protein with Mutation E533K Deposited 2024-09-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 380–786（407 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；PEG 8K (18%), 0.1M sodium citrate, 0.1M succinate pH 5.5, 1M lithium chloride
Resolution 2.16 Å R-free 0.263
9DHU The Retinoblastoma Protein with Mutation E533K Deposited 2024-09-04 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 380–786（407 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；PEG 8K (18%), 0.1M sodium citrate, 0.1M succinate pH 5.5, 1M lithium chloride
Resolution 2.16 Å R-free 0.263

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.