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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P08669 New Search
27PDB entries
27Biological assembly
153chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5FT2 Sub-tomogram averaging of Lassa virus glycoprotein spike from virus- like particles at pH 5 Deposited 2016-01-09 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 75–237（163 aa） Fragment：RECEPTOR BINDING DOMAIN, UNP RESIDUES 75-237
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer 50 MM BUFFER OF SUCCINIC ACID, DIHYDROGEN PHOSPHATE AND GLYCINE (SPG)；pH 5.2；50 MM BUFFER OF SUCCINIC ACID, DIHYDROGEN PHOSPHATE AND GLYCINE (SPG)
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；VITRIFICATION 1 -- CRYOGEN- ETHANE-PROPANE MIXTURE, HUMIDITY- 80, TEMPERATURE- 120, INSTRUMENT- GATAN CRYOPLUNGE 3, METHOD- BLOT FOR 3 SECONDS BEFORE PLUNGING.,
Resolution 16.40 Å
5VK2 Structural basis for antibody-mediated neutralization of Lassa virus Deposited 2017-04-20 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–259（259 aa） Fragment：UNP residues 1-259
Chain B 1–259（259 aa） Fragment：UNP residues 1-259
Chain C 1–259（259 aa） Fragment：UNP residues 1-259
Chain a 260–423（164 aa） Fragment：UNP residues 260-423
Chain b 260–423（164 aa） Fragment：UNP residues 260-423
Chain c 260–423（164 aa） Fragment：UNP residues 260-423
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；296 K；0.1M Tris pH 8, 15-18% PEG 3350 and 0.1M-0.3M magnesium acetate
Resolution 3.20 Å R-free 0.231
6P95 Structure of Lassa virus glycoprotein in complex with Fab 25.6A Deposited 2019-06-09 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–433（174 aa）
Chain b 260–433（174 aa）
Chain c 260–433（174 aa）
Mutation：R207C, L258R, L259RG Mutation：R207C, L258R, L259RG Mutation：R207C, L258R, L259RG Mutation：G360P, M332T, E329C Mutation：G360P, M332T, E329C Mutation：G360P, M332T, E329C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M Tris pH 8, 15-18% PEG 3350 and 0.1 M-0.3 M magnesium acetate
Resolution 3.50 Å R-free 0.247
7PUY Structure of the membrane soluble spike complex from the Lassa virus in a C3-symmetric map Deposited 2021-10-01 Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7PVD Structure of the membrane soluble spike complex from the Lassa virus in a C1-symmetric map focused on the ectodomain Deposited 2021-10-02 Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
7S8H Structure of Lassa virus glycoprotein bound to Fab 18.5C and Fab 36.1F Deposited 2021-09-17 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 59–259（201 aa）
Chain a 260–424（165 aa）
Mutation：G243C, Residues 256-259 mutated from RRLL to RRRR Mutation：E329P, M332T, I350C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293.15 K；0.1 M Tris, pH 8.0, 1.25 M LiCl and 15% PEG 8k
Resolution 2.70 Å R-free 0.251
7TYV Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C Deposited 2022-02-14 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–423（164 aa）
Chain b 260–423（164 aa）
Chain c 260–423（164 aa）
Mutation：R207C, Residues 256-259 mutated from RRLL to RRRR Mutation：R207C, Residues 256-259 mutated from RRLL to RRRR Mutation：R207C, Residues 256-259 mutated from RRLL to RRRR Mutation：E329P, M332T, G360C Mutation：E329P, M332T, G360C Mutation：E329P, M332T, G360C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
7UOT Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D Deposited 2022-04-13 Assembly 1 Other combination Heteromer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.77 Å
7UOV Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D Deposited 2022-04-14 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.75 Å
8EJD Structure of lineage IV Lassa virus glycoprotein complex (strain Josiah) Deposited 2022-09-16 Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Mutation：R207C, L258R, L259R Mutation：R207C, L258R, L259R Mutation：R207C, L258R, L259R Mutation：E329P, G360C Mutation：E329P, G360C Mutation：E329P, G360C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS
cryo-EM vitrification conditions Cryogen ETHANE；Wait time 10 s; blotting time varied between 3-7 s; blotting force of 0
Resolution 3.80 Å
8EJH Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab Deposited 2022-09-16 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Mutation：R207C, L258R, L259R Mutation：R207C, L258R, L259R Mutation：R207C, L258R, L259R Mutation：E329P, G360C Mutation：E329P, G360C Mutation：E329P, G360C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 MAN alpha-D-mannopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS
cryo-EM vitrification conditions Cryogen ETHANE；Wait time 10 s; blotting time varied between 3-7 s; blotting force of 0
Resolution 3.71 Å
8EJI Lassa virus glycoprotein complex (Josiah) bound to 19.7E Fab Deposited 2022-09-16 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Mutation：R207C, L258R, L259R Mutation：R207C, L258R, L259R Mutation：R207C, L258R, L259R Mutation：E328P, G359C Mutation：E328P, G359C Mutation：E328P, G359C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 14 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS
cryo-EM vitrification conditions Cryogen ETHANE；Wait time 10 s; blotting time varied between 3-7 s; blotting force of 0
Resolution 3.81 Å
8T5C Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5 Deposited 2023-06-13 Assembly 1 Other combination Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 59–257（199 aa）
Chain B 59–257（199 aa）
Chain C 59–257（199 aa）
Chain a 260–418（159 aa）
Chain b 260–418（159 aa）
Chain c 260–418（159 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 23 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.70 Å
8TYC Lassa GPC (strain Josiah) bound to rabbit polyclonal base-targeting antibody Base-1 Deposited 2023-08-24 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–423（164 aa）
Chain b 260–423（164 aa）
Chain c 260–423（164 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8TYE Lassa GPC (strain Josiah) bound to rabbit polyclonal fusion-peptide-targeting antibody FP-1 Deposited 2023-08-25 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 14 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8VCV Lineage IV Lassa virus glycoprotein (Josiah) in complex with rabbit polyclonal antibody (GPC-C epitope) Deposited 2023-12-14 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
8VE8 Lineage IV Lassa virus glycoprotein (Josiah) in complex with rabbit polyclonal antibody (GP1-A epitope) Deposited 2023-12-18 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
9CJ7 Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F Deposited 2024-07-05 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9CJ8 Lineage IV Lassa virus glycoprotein (Josiah) in complex with rabbit polyclonal antibody (LAVA01-like epitope) Deposited 2024-07-05 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 25 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.74 Å
9CK7 Lineage IV Lassa virus glycoprotein (Josiah) in complex with polyclonal antibody (GPC-A epitope) from rabbit 187 Deposited 2024-07-08 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.45 Å
9CK8 Lineage IV Lassa virus glycoprotein (Josiah) in complex with polyclonal antibody (GPC-A epitope) from rabbit 189 Deposited 2024-07-08 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–424（165 aa）
Chain b 260–424（165 aa）
Chain c 260–424（165 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 17 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.04 Å
9MHE Native tagless Lassa virus spike complex bound to ARN-75039 at pH 8.0 Deposited 2024-12-11 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 10 UNX UNKNOWN LIGAND × 2 A1BK9 (4S)-3-(4-tert-butoxyphenyl)-7-methyl-6-{4-[(propan-2-yl)oxy]phenyl}imidazo[1,2-a]pyridine × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.01 Å
9MIV Native tagless Lassa virus spike complex pH 6.0 Deposited 2024-12-13 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 UNX UNKNOWN LIGAND × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.02 Å
9MIY Focused reconstruction of the transmembrane region of the Lassa virus spike complex Deposited 2024-12-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–58（58 aa）
Chain B 1–58（58 aa）
Chain C 1–58（58 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.72 Å
9MJ1 Native tagless Lassa virus spike complex bound at pH 8.0 Deposited 2024-12-13 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 UNX UNKNOWN LIGAND × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 1.90 Å
9MJ2 Flag-tag Lassa virus spike complex at pH 6.0 Deposited 2024-12-13 Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 59–259（201 aa）
Chain B 59–259（201 aa）
Chain C 59–259（201 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 UNX UNKNOWN LIGAND × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.58 Å
9R8U Flag-tag LASV spike acidified to pH 5.0 and re-equilibrated to pH 8.0 Deposited 2025-05-16 Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–259（259 aa）
Chain B 1–259（259 aa）
Chain C 1–259（259 aa）
Chain a 260–491（232 aa）
Chain b 260–491（232 aa）
Chain c 260–491（232 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 UNX UNKNOWN LIGAND × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.