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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P09603 New Search
8PDB entries
16Biological assembly
39chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1HMC THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR Deposited 1993-12-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 36–181（146 aa）
Chain B 36–181（146 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
3UEZ Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1 Deposited 2011-10-31 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain E 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain F 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1M Tris HCl, 1.0M ammonium sulphate, pH 8.50, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 3.41 Å R-free 0.274
3UEZ Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1 Deposited 2011-10-31 Assembly 2 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain G 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain H 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1M Tris HCl, 1.0M ammonium sulphate, pH 8.50, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 3.41 Å R-free 0.274
3UF2 Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine Deposited 2011-10-31 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain B 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.1M magnesium chloride, 0.1M sodium citrate pH 5.0, 15% w/v PEG 4000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.75 Å R-free 0.190
3UF2 Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine Deposited 2011-10-31 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain D 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.1M magnesium chloride, 0.1M sodium citrate pH 5.0, 15% w/v PEG 4000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.75 Å R-free 0.190
3UF2 Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine Deposited 2011-10-31 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain F 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.1M magnesium chloride, 0.1M sodium citrate pH 5.0, 15% w/v PEG 4000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.75 Å R-free 0.190
3UF2 Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine Deposited 2011-10-31 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain H 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.1M magnesium chloride, 0.1M sodium citrate pH 5.0, 15% w/v PEG 4000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.75 Å R-free 0.190
3UF2 Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine Deposited 2011-10-31 Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain I 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain J 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；0.1M magnesium chloride, 0.1M sodium citrate pH 5.0, 15% w/v PEG 4000, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.75 Å R-free 0.190
4ADF CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1 Deposited 2011-12-23 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain G 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain H 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain I 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain J 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain K 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain L 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；0.1 M TRIS HCL, PH 8.50, 1.0 M AMMONIUM PHOSPHATE MONOBASIC
Resolution 4.40 Å R-free 0.276
4ADF CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1 Deposited 2011-12-23 Assembly 2 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain S 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain T 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain U 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain V 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain W 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Chain X 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 8.5；0.1 M TRIS HCL, PH 8.50, 1.0 M AMMONIUM PHOSPHATE MONOBASIC
Resolution 4.40 Å R-free 0.276
4FA8 Multi-pronged modulation of cytokine signaling Deposited 2012-05-21 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain E 36–180（145 aa） Fragment：UNP residues 36-180
Chain F 36–180（145 aa） Fragment：UNP residues 36-180
Chain G 36–180（145 aa） Fragment：UNP residues 36-180
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；8% PEG8000, 0.1M imidazole pH8.0, 0.22M calcium acetate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.20 Å R-free 0.260
4FA8 Multi-pronged modulation of cytokine signaling Deposited 2012-05-21 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 36–180（145 aa） Fragment：UNP residues 36-180
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；8% PEG8000, 0.1M imidazole pH8.0, 0.22M calcium acetate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.20 Å R-free 0.260
4FA8 Multi-pronged modulation of cytokine signaling Deposited 2012-05-21 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 36–180（145 aa） Fragment：UNP residues 36-180
Chain G 36–180（145 aa） Fragment：UNP residues 36-180
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；8% PEG8000, 0.1M imidazole pH8.0, 0.22M calcium acetate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.20 Å R-free 0.260
4WRL Structure of the human CSF-1:CSF-1R complex Deposited 2014-10-24 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 33–181（149 aa） Fragment：UNP residues 33-181
Chain D 33–181（149 aa） Fragment：UNP residues 33-181
Not recorded SIA N-acetyl-alpha-neuraminic acid × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M Lithium sulfate monohydrate, 0.1 M Tris pH 8.5 and 28% w/v PEG 3350
Resolution 2.80 Å R-free 0.261
4WRM Structure of the human CSF-1:CSF-1R complex Deposited 2014-10-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 33–181（149 aa） Fragment：UNP RESIDUES 33-181
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；0.1 M NaCl, 0.1 M Tris pH 8.0 and 8% w/v PEG 20000
Resolution 6.85 Å R-free 0.359
5LXF Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant Deposited 2016-09-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 33–190（158 aa）
Chain B 33–190（158 aa）
Mutation：C31S Mutation：C31S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293 K；0.03M Bis-Tris pH 6.5; 0.17M Mg Formate; 16.67% PEG 3350; 0.07M Bis-Tris pH 5.5
Resolution 2.00 Å R-free 0.253

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.