当前蛋白身份：P09936
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 2ETL Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) 提交 2005-10-27 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
未记录 | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；2.4 M Ammonium Sulfate, 0.1 M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
|
分辨率 2.40 Å R-free 0.274 |
| 2ETL Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) 提交 2005-10-27 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
未记录 | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；2.4 M Ammonium Sulfate, 0.1 M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
|
分辨率 2.40 Å R-free 0.274 |
| 2ETL Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) 提交 2005-10-27 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 B
1–223（223 aa）
|
未记录 | CL CHLORIDE ION × 8 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；2.4 M Ammonium Sulfate, 0.1 M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
|
分辨率 2.40 Å R-free 0.274 |
| 2ETL Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) 提交 2005-10-27 | Assembly 4 蛋白同源多聚体 同源多聚体；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
1–223（223 aa）
|
未记录 | CL CHLORIDE ION × 8 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；2.4 M Ammonium Sulfate, 0.1 M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
|
分辨率 2.40 Å R-free 0.274 |
| 2LEN Solution structure of UCHL1 S18Y variant 提交 2011-06-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：S18Y | 未记录非水小分子 | SOLUTION NMR |
NMR测量条件
pH 6.5；298 K；离子强度（mmCIF原始值）100；压力 ambient
NMR样品组成
0.7-0.8mM [U-99% 13C; U-99% 15N] UCHL1 S18Y variant-1, 20mM sodium phosphate-2, 100mM sodium chloride-3, 3mM DTT-4, 90% H2O-5, 10% D2O-6, 90% H2O/10% D2O | 90% H2O/10% D2O
|
分辨率未提供 |
| 3IFW Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester. 提交 2009-07-26 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：S18Y | GVE METHYL 4-AMINOBUTANOATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；298 K；2.4 M ammonium sulfate, 0.1M BICINE, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
分辨率 2.40 Å R-free 0.256 |
| 3IRT Crystal Structure of the I93M Mutant of Ubiquitin Carboxy-terminal Hydrolase L1 提交 2009-08-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：I93M | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M Ammonium Sulfate, 0.1 M TRIS Hydrochloride, 0.1 M Sodium Sodium Malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.254 |
| 3IRT Crystal Structure of the I93M Mutant of Ubiquitin Carboxy-terminal Hydrolase L1 提交 2009-08-24 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
突变：I93M | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M Ammonium Sulfate, 0.1 M TRIS Hydrochloride, 0.1 M Sodium Sodium Malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.254 |
| 3KVF Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 提交 2009-11-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：I93M | GVE METHYL 4-AMINOBUTANOATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；298 K；0.1M BICINE, 2.4M Ammonium Sulfate, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.284 |
| 3KW5 Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester 提交 2009-11-30 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–223（223 aa）
|
未记录 | GVE METHYL 4-AMINOBUTANOATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 9；298 K；0.1M BICINE, 2.4M Ammonium Sulfate, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.83 Å R-free 0.286 |
| 4DM9 The Crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) bound to a tripeptide fluoromethyl ketone Z-VAE(OMe)-FMK 提交 2012-02-07 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–223（223 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4M ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
分辨率 2.35 Å R-free 0.250 |
| 4DM9 The Crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) bound to a tripeptide fluoromethyl ketone Z-VAE(OMe)-FMK 提交 2012-02-07 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
1–223（223 aa）
|
未记录 | 未记录非水小分子 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4M ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
分辨率 2.35 Å R-free 0.250 |
| 4JKJ Crystal Structure of the S18Y Variant of Ubiquitin Carboxy-terminal Hydrolase L1 提交 2013-03-09 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：S18Y | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4M Ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.245 |
| 4JKJ Crystal Structure of the S18Y Variant of Ubiquitin Carboxy-terminal Hydrolase L1 提交 2013-03-09 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
突变：S18Y | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4M Ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.245 |
| 4JKJ Crystal Structure of the S18Y Variant of Ubiquitin Carboxy-terminal Hydrolase L1 提交 2013-03-09 | Assembly 3 蛋白同源多聚体 同源多聚体；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：S18Y | SO4 SULFATE ION × 8 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4M Ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.245 |
| 4JKJ Crystal Structure of the S18Y Variant of Ubiquitin Carboxy-terminal Hydrolase L1 提交 2013-03-09 | Assembly 4 蛋白同源多聚体 同源多聚体；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 B
1–223（223 aa）
|
突变：S18Y | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4M Ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.15 Å R-free 0.245 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 10 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 J
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 5 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 E
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 6 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 F
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 7 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 G
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 8 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 H
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 7ZM0 Structure of UCHL1 in complex with GK13S inhibitor 提交 2022-04-18 | Assembly 9 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 I
1–223（223 aa）
|
突变：lysine-dimethylated | JMF (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.3 M ammonium sulphate, 110 mM K3PO4 and 90 mM K2HPO4
|
分辨率 2.24 Å R-free 0.288 |
| 8DY8 Crystal structure of the R178Q mutant of ubiquitin carboxy terminal hydrolase L1 (UCH-L1) 提交 2022-08-03 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：R178Q | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；2.4 M Ammonium Sulfate, 0.1 M HEPES
|
分辨率 2.10 Å R-free 0.265 |
| 8DY8 Crystal structure of the R178Q mutant of ubiquitin carboxy terminal hydrolase L1 (UCH-L1) 提交 2022-08-03 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
突变：R178Q | SO4 SULFATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；2.4 M Ammonium Sulfate, 0.1 M HEPES
|
分辨率 2.10 Å R-free 0.265 |
| 8EDE Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazide bound to Ubiquitin C-terminal Hydrolase-L1 提交 2022-09-04 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
未记录 | WEU 2-[(4-chlorophenyl)-methyl-amino]-~{N}'-ethanoyl-ethanehydrazide × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；294.15 K；0.1M tri-Sodium citrate
2.4M Ammonium sulfate
|
分辨率 1.80 Å R-free 0.227 |
| 8EDE Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazide bound to Ubiquitin C-terminal Hydrolase-L1 提交 2022-09-04 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
未记录 | WEU 2-[(4-chlorophenyl)-methyl-amino]-~{N}'-ethanoyl-ethanehydrazide × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；294.15 K；0.1M tri-Sodium citrate
2.4M Ammonium sulfate
|
分辨率 1.80 Å R-free 0.227 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 10 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 J
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 C
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 4 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 D
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 5 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 E
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 6 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 F
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 7 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 G
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 8 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 H
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8PW1 Structure of human UCHL1 in complex with CG341 inhibitor 提交 2023-07-19 | Assembly 9 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 I
1–223（223 aa）
|
未记录 | GKO (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.49 M ammonium sulfate, 85 mM trisodium citrate
|
分辨率 2.20 Å R-free 0.271 |
| 8XI7 The Crystal Structure of UCHL1 from Biortus. 提交 2023-12-19 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–223（223 aa）
链 B
1–223（223 aa）
|
未记录 | EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, SITTING DROP；293 K；2.1M ammonium sulfate, 2% PEG 400, 100mM HEPES, pH 7.0
|
分辨率 1.95 Å R-free 0.231 |
| 9O4M Crystal structure of Ubiquitin Carboxy Terminal Hydrolase L1 Q209C mutant covalently crosslinked to ubiquitin genetically encoded with N6-(6-bromohexanoyl)-L-lysine 提交 2025-04-08 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 B
1–223（223 aa）
|
突变：Q209C | 6NA HEXANOIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；2.1 M DL-Malic acid
|
分辨率 2.00 Å R-free 0.262 |
| 9O4M Crystal structure of Ubiquitin Carboxy Terminal Hydrolase L1 Q209C mutant covalently crosslinked to ubiquitin genetically encoded with N6-(6-bromohexanoyl)-L-lysine 提交 2025-04-08 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–223（223 aa）
|
突变：Q209C | 6NA HEXANOIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；2.1 M DL-Malic acid
|
分辨率 2.00 Å R-free 0.262 |