Current Protein Identity：P12263
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 4MO3 Crystal Structure of Porcine C2 Domain of Blood Coagulation Factor VIII Deposited 2013-09-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain M
1971–2129（159 aa）
Fragment：C2 domain (UNP residues 1971-2129)
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 10.4；277 K；2:1 crystallization buffer (0.1 M magnesium acetate, 10% ethanol) to protein, crystals formed overnight with 0.1 M CHES buffer and 220 uL Hampton Research Al's oil over 400 uL reservoir, pH 10.4, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.70 Å R-free 0.209 |
| 6MF0 Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII Deposited 2018-09-07 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: monomeric（1） Review required |
Chain A
1–386（386 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A
762–771（10 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A
1438–1820（383 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B
1–386（386 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B
762–771（10 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain B
1438–1820（383 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
|
Not recorded | CA CALCIUM ION × 2 ZN ZINC ION × 2 CU1 COPPER (I) ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；16% PEG3350, 0.025 M magnesium chloride, 0.025 M HEPES
|
Resolution 3.20 Å R-free 0.287 |
| 6MF0 Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII Deposited 2018-09-07 | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–386（386 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A
762–771（10 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
Chain A
1438–1820（383 aa）
Fragment：UNP residues 1-386 (pig), 387-761 (human), 762-771,1438-1820 (pig), 2039-2351 (human)
|
Not recorded | CA CALCIUM ION × 1 ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；16% PEG3350, 0.025 M magnesium chloride, 0.025 M HEPES
|
Resolution 3.20 Å R-free 0.287 |
| 7K66 Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor Deposited 2020-09-18 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–405（405 aa）
Chain A
1438–1820（383 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 1 CA CALCIUM ION × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.7；293 K；17.5 %(w/v) PEG 1500, 50 mM HEPES (pH 7.7)
|
Resolution 3.92 Å R-free 0.322 |
| 7KBT Factor VIII in complex with the anti-C2 domain antibody, G99 Deposited 2020-10-02 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–386（386 aa）
Chain A
762–771（10 aa）
Chain A
1438–1820（383 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；8 - 18% PEG 1500, PEG 6K, or PEG 10K and 50mM malic acid, pH 7.
|
Resolution 4.15 Å R-free 0.338 |
| 7S0P Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine Deposited 2021-08-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain M
1974–2129（156 aa）
|
Not recorded | SEP PHOSPHOSERINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；2:1 drop ratio
0.1 M CHES (pH 7.4)
0.1M magnesium acetate
10% ethanol (v/v)
Crystal soaked with 5 mM OPLS
|
Resolution 1.30 Å R-free 0.156 |
| 8G6I Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor Deposited 2023-02-15 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–405（405 aa）
Chain A
1438–1820（383 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；150 mM NaCl, 20 mM HEPES pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.23 Å |
| 8TY1 Cryo-EM structure of coagulation factor VIII bound to NB2E9 Deposited 2023-08-24 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–391（391 aa）
Chain A
1438–1820（383 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；20 mM HEPES (pH 7.4) and 150 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.46 Å |