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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P15884 New Search
5PDB entries
10Biological assembly
18chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2KWF The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1 Deposited 2010-04-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 11–27（17 aa） Fragment：UNP residues 11-27
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition 1 mM DSS-1, 20 mM MES-2, 1 mM beta-mercaptoethanol-3, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
6OD3 Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence Deposited 2019-03-25 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain B 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 7 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；25% PEG3350, 0.1 M Tris, pH 8.5, 0.2 M sodium chloride
Resolution 1.49 Å R-free 0.237
6OD3 Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence Deposited 2019-03-25 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain E 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain F 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；25% PEG3350, 0.1 M Tris, pH 8.5, 0.2 M sodium chloride
Resolution 1.49 Å R-free 0.237
6OD3 Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence Deposited 2019-03-25 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain H 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；25% PEG3350, 0.1 M Tris, pH 8.5, 0.2 M sodium chloride
Resolution 1.49 Å R-free 0.237
6OD3 Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence Deposited 2019-03-25 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain I 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain J 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；25% PEG3350, 0.1 M Tris, pH 8.5, 0.2 M sodium chloride
Resolution 1.49 Å R-free 0.237
6OD4 Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence Deposited 2019-03-25 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain B 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；292 K；20% PEG4000, 10% 2-propanol, 0.1 M sodium citrate tribasic dihydrate, pH 5.6
Resolution 1.70 Å R-free 0.267
6OD4 Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence Deposited 2019-03-25 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain H 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；292 K；20% PEG4000, 10% 2-propanol, 0.1 M sodium citrate tribasic dihydrate, pH 5.6
Resolution 1.70 Å R-free 0.267
6OD5 Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines Deposited 2019-03-25 Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain B 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 2 CL CHLORIDE ION × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；30% PEG4000, 0.1 M Tris, pH 8.5, 0.2 M lithium sulfate monohydrate or 0.2 M sodium acetate trihydrate
Resolution 2.05 Å R-free 0.280
6OD5 Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines Deposited 2019-03-25 Assembly 2 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers
Chain C 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Chain D 405–464（60 aa） Fragment：C-terminal bHLH domain (UNP residues 405-464)
Not recorded EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；30% PEG4000, 0.1 M Tris, pH 8.5, 0.2 M lithium sulfate monohydrate or 0.2 M sodium acetate trihydrate
Resolution 2.05 Å R-free 0.280
8OSB TWIST1-TCF4-ALX4 complex on specific DNA Deposited 2023-04-18 Assembly 1 Protein–DNA Heteromer；Protein × 3 PDB declaration: pentameric（5） Consistent with all polymers
Chain A 565–624（60 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；Sodium Cacodylate buffer (pH 7.5), 100 mM magnesium acetate, 18 % Glycerol, 20 % 2-Methyl-2,4-pentanediol, 6-7% PEG (Mw 8000)
Resolution 2.90 Å R-free 0.270

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.