Current Protein Identity：P16144
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1QG3 CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4 Deposited 1999-04-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1126–1320（195 aa）
Fragment：FIRST TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS
Chain B
1126–1320（195 aa）
Fragment：FIRST TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS
|
Not recorded | CAC CACODYLATE ION × 2 SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.2；100 MM CACODYLIC ACID/NAOH PH 6.2 200 MM LI2SO4 30% 400 MM POLYETHYLENE GLYCOL
|
Resolution 2.15 Å R-free 0.262 |
| 2YRZ Solution structure of the fibronectin type III domain of human Integrin beta-4 Deposited 2007-04-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1518–1622（105 aa）
Fragment：fn3
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 7；296 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition
1.21mM sample U-15N,13C; 20mM d-Tris-HCl; 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90% H2O, 10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 3F7P Crystal structure of a complex between integrin beta4 and plectin Deposited 2008-11-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1126–1370（245 aa）
Fragment：Fibronectin type-III, residues 1126-1370
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.8；298 K；0.1M Sodium Acetate, 0.2M CaCl2, 10% PEG 6000, pH 5.8, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.75 Å R-free 0.257 |
| 3F7P Crystal structure of a complex between integrin beta4 and plectin Deposited 2008-11-10 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
1126–1370（245 aa）
Fragment：Fibronectin type-III, residues 1126-1370
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.8；298 K；0.1M Sodium Acetate, 0.2M CaCl2, 10% PEG 6000, pH 5.8, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.75 Å R-free 0.257 |
| 3F7P Crystal structure of a complex between integrin beta4 and plectin Deposited 2008-11-10 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain E
1126–1370（245 aa）
Fragment：Fibronectin type-III, residues 1126-1370
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.8；298 K；0.1M Sodium Acetate, 0.2M CaCl2, 10% PEG 6000, pH 5.8, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.75 Å R-free 0.257 |
| 3F7Q First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4 Deposited 2008-11-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1126–1355（230 aa）
Fragment：Fibronectin type-III, residues 1126-1355
|
Not recorded | CL CHLORIDE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 1PE PENTAETHYLENE GLYCOL × 1 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；298 K；0.1M Tris-HCl, 0.3M NaCl, 24% PEG 200, pH 7.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 1.75 Å R-free 0.182 |
| 3F7Q First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4 Deposited 2008-11-10 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1126–1355（230 aa）
Fragment：Fibronectin type-III, residues 1126-1355
|
Not recorded | CL CHLORIDE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 EDO 1,2-ETHANEDIOL × 1 PG4 TETRAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.5；298 K；0.1M Tris-HCl, 0.3M NaCl, 24% PEG 200, pH 7.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 1.75 Å R-free 0.182 |
| 3F7R First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4 Deposited 2008-11-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1126–1370（245 aa）
Fragment：Fibronectin type-III, residues 1126-1370
|
Not recorded | CL CHLORIDE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M Cacodylate, 18.75% PEG 600, 6.25% Glycerol, 0.7M NaCl, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.04 Å R-free 0.215 |
| 3FQ4 Crystal structure of the Calx-beta domain of integrin beta4 Deposited 2009-01-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
989–1107（119 aa）
Fragment：Calx-beta domain, residues 989-1107
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；50mM Tris-HCl, 26% PEG 1500, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.49 Å R-free 0.189 |
| 3FQ4 Crystal structure of the Calx-beta domain of integrin beta4 Deposited 2009-01-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
989–1107（119 aa）
Fragment：Calx-beta domain, residues 989-1107
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；50mM Tris-HCl, 26% PEG 1500, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.49 Å R-free 0.189 |
| 3FSO Crystal structure of the Calx-beta domain of integrin beta4, calcium soak Deposited 2009-01-11 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
989–1107（119 aa）
Fragment：Calx-beta domain, residues 989-1107
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；50mM Tris-HCl, 26% PEG 1500; CRYSTAL WAS SOAKED IN 50mM Tris-HCl, 25% PEG 1500, 10mM CaCl2 PRIOR TO DATA COLLECTION, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.41 Å R-free 0.211 |
| 3FSO Crystal structure of the Calx-beta domain of integrin beta4, calcium soak Deposited 2009-01-11 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
989–1107（119 aa）
Fragment：Calx-beta domain, residues 989-1107
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.3；298 K；50mM Tris-HCl, 26% PEG 1500; CRYSTAL WAS SOAKED IN 50mM Tris-HCl, 25% PEG 1500, 10mM CaCl2 PRIOR TO DATA COLLECTION, pH 8.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.41 Å R-free 0.211 |
| 3H6A Structure of the Calx-beta domain of integrin beta4 crystallized in the presence of calcium Deposited 2009-04-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
989–1107（119 aa）
Fragment：CALX-BETA DOMAIN, RESIDUES 989-1107
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.9；298 K；50MM TRIS-HCL, 2MM CACL2, 26% PEG 1500, pH 7.9, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.61 Å R-free 0.212 |
| 3H6A Structure of the Calx-beta domain of integrin beta4 crystallized in the presence of calcium Deposited 2009-04-23 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
989–1107（119 aa）
Fragment：CALX-BETA DOMAIN, RESIDUES 989-1107
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.9；298 K；50MM TRIS-HCL, 2MM CACL2, 26% PEG 1500, pH 7.9, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.61 Å R-free 0.212 |
| 4Q58 Crystal structure of the plectin 1a actin-binding domain/integrin beta 4 fragment complex Deposited 2014-04-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
1126–1320（195 aa）
Fragment：fibronectin type III domains 1 and 2 (UNP residues 1126-1320)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20 mM HEPES, pH 6.5, 150 mM sodium formate, 7.5% PEG550 MME, 3% sucrose, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 4.00 Å R-free 0.287 |
| 4Q58 Crystal structure of the plectin 1a actin-binding domain/integrin beta 4 fragment complex Deposited 2014-04-16 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1126–1320（195 aa）
Fragment：fibronectin type III domains 1 and 2 (UNP residues 1126-1320)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；295 K；20 mM HEPES, pH 6.5, 150 mM sodium formate, 7.5% PEG550 MME, 3% sucrose, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 4.00 Å R-free 0.287 |
| 4WTW Crystal structure of the third FnIII domain of integrin beta4 Deposited 2014-10-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1457–1548（92 aa）
Fragment：Third FnIII domain, UNP residues 1457-1548
|
Not recorded | SO4 SULFATE ION × 2 1PE PENTAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M Tris-HCl, 12.5% glycerol, 36% PEG 600, 0.5 M (NH4)2SO4
|
Resolution 1.61 Å R-free 0.180 |
| 4WTW Crystal structure of the third FnIII domain of integrin beta4 Deposited 2014-10-30 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1457–1548（92 aa）
Fragment：Third FnIII domain, UNP residues 1457-1548
|
Not recorded | EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M Tris-HCl, 12.5% glycerol, 36% PEG 600, 0.5 M (NH4)2SO4
|
Resolution 1.61 Å R-free 0.180 |
| 4WTX Crystal structure of the fourth FnIII domain of integrin beta4 Deposited 2014-10-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1572–1666（95 aa）
Fragment：Fourth FnIII domain, UNP residues 1572-1666
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M Sodium Acetate (pH 4.2), 0.7 M NaH2PO4, 1.05 M K2HPO4, 2 mM DTT
|
Resolution 1.50 Å R-free 0.218 |
| 6GVK Second pair of Fibronectin type III domains of integrin beta4 (T1663R mutant) bound to the bullous pemphigoid antigen BP230 (BPAG1e) Deposited 2018-06-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1527–1736（210 aa）
|
Mutation：T1663R | GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；0.1 M Na-acetate (pH 5.0), 20% PEG 6000, 0.2 M MgCl2
|
Resolution 1.55 Å R-free 0.210 |
| 6GVL Second pair of Fibronectin type III domains of integrin beta4 bound to the bullous pemphigoid antigen BP230 (BPAG1e) Deposited 2018-06-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1527–1736（210 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.2；298 K；0.1 phosphate-citrate pH 4.2, 20% PEG 8000, 0.2 M NaCl
|
Resolution 2.05 Å R-free 0.236 |