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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P16410 New Search
22PDB entries
33Biological assembly
39chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1AH1 CTLA-4, NMR, 20 STRUCTURES Deposited 1997-04-11 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 37–161（125 aa） Fragment：EXTRACELLULAR N-TERMINAL IMMUNOGLOBULIN V-LIKE
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；303 K
Resolution not provided
1H6E MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH CTLA-4 INTERNALIZATION PEPTIDE TTGVYVKMPPT Deposited 2001-06-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain P 197–207（11 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；HANGING DROPS CONTAINING A 1:1 MIXTURE OF COMPLEX SOLUTION 6MG/ML PROTEIN AND 1MM 11MER PEPTIDE SOLUTION IN 20MM HEPES PH7.5, 1MM DTT AND RESERVOIR BUFFER 1.4-2.4M SODIUM CHLORIDE, 0.1M MES PH6.2-7.0, 0.4M NA/K PHOSPHATE, 15% GLYCEROL, pH 7.00
Resolution 3.60 Å R-free 0.317
1I85 CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX Deposited 2001-03-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 36–161（126 aa） Fragment：EXTRACELLULAR DOMAIN
Chain D 36–161（126 aa） Fragment：EXTRACELLULAR DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；PEG20K, HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.20 Å R-free 0.300
1I8L HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX Deposited 2001-03-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 36–161（126 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 36-161
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 MAN alpha-D-mannopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；298 K；16% PEG 8000, 0.1M CACODYLATE, PH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 3.00 Å R-free 0.257
1I8L HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX Deposited 2001-03-14 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 36–161（126 aa） Fragment：EXTRACELLULAR DOMAIN, RESIDUES 36-161
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 MAN alpha-D-mannopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.3；298 K；16% PEG 8000, 0.1M CACODYLATE, PH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 3.00 Å R-free 0.257
2X44 Structure of a strand-swapped dimeric form of CTLA-4 Deposited 2010-01-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 36–161（126 aa） Fragment：RESIDUES 36-161
Mutation：YES No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.02 M MAGNESIUM CHLORIDE, 0.1 M HEPES PH 7.5, 22 % W/V POLYACRYLIC ACID 5100 SODIUM SALT, 0.4 M NDSB-256 (OR 6 % 1,6-DIAMINOHEXANE).
Resolution 2.60 Å R-free 0.245
3BX7 Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4 Deposited 2008-01-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 38–161（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.4；293.15 K；1.4 M Na-malonate, pH 8.4, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
Resolution 2.10 Å R-free 0.226
3OSK Crystal structure of human CTLA-4 apo homodimer Deposited 2010-09-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 36–161（126 aa） Fragment：Extracellular domain, UNP residues 36-161
Chain B 36–161（126 aa） Fragment：Extracellular domain, UNP residues 36-161
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；295 K；25% Polyethylene glycol 3350 (w/v), 100mM bis-Tris pH 5.5, 200mM ammonium acetate, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 1.80 Å R-free 0.275
5GGV CTLA-4 in complex with tremelimumab Fab Deposited 2016-06-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain Y 36–161（126 aa） Fragment：UNP residues 36-161
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M sodium citrate tribasic dihydrate, pH 5.6, 12% PEG4,000, 100 mM NaCl
Resolution 2.00 Å R-free 0.214
5TRU Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4 Deposited 2016-10-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 37–154（118 aa） Fragment：UNP residues 37-154
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；291 K；0.1M ammonium sulfate, 0.1M Tris pH 7.5, 20% PEG 1500
Resolution 3.00 Å R-free 0.268
5TRU Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4 Deposited 2016-10-27 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain c 37–154（118 aa） Fragment：UNP residues 37-154
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；291 K；0.1M ammonium sulfate, 0.1M Tris pH 7.5, 20% PEG 1500
Resolution 3.00 Å R-free 0.268
5XJ3 Complex structure of ipilimumab-scFv and CTLA-4 Deposited 2017-04-29 Assembly 12 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain L 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9；291 K；100 mM BICINE, 10% PEG 20000, 2% 1,4-Dioxane, pH 9.0.
Resolution 3.20 Å R-free 0.264
5XJ3 Complex structure of ipilimumab-scFv and CTLA-4 Deposited 2017-04-29 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9；291 K；100 mM BICINE, 10% PEG 20000, 2% 1,4-Dioxane, pH 9.0.
Resolution 3.20 Å R-free 0.264
5XJ3 Complex structure of ipilimumab-scFv and CTLA-4 Deposited 2017-04-29 Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain F 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9；291 K；100 mM BICINE, 10% PEG 20000, 2% 1,4-Dioxane, pH 9.0.
Resolution 3.20 Å R-free 0.264
5XJ3 Complex structure of ipilimumab-scFv and CTLA-4 Deposited 2017-04-29 Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain I 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 9；291 K；100 mM BICINE, 10% PEG 20000, 2% 1,4-Dioxane, pH 9.0.
Resolution 3.20 Å R-free 0.264
6RP8 Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution Deposited 2019-05-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain c 37–154（118 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；PEG4000, pH6
Resolution 2.60 Å R-free 0.267
6RP8 Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution Deposited 2019-05-14 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 37–154（118 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；PEG4000, pH6
Resolution 2.60 Å R-free 0.267
6RPJ A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4 Deposited 2019-05-14 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 37–156（120 aa）
Chain G 37–156（120 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；PEG400
Resolution 3.25 Å R-free 0.262
6RPJ A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4 Deposited 2019-05-14 Assembly 2 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 37–156（120 aa）
Chain E 37–156（120 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；PEG400
Resolution 3.25 Å R-free 0.262
6RQM A blocking anti-CTLA-4 Nanobody (KN044) complexed with CTLA-4 Deposited 2019-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 37–161（125 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；PEG400,
Resolution 3.00 Å R-free 0.313
6XY2 Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody Deposited 2020-01-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 38–160（123 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.5；293 K；1M Li2SO4, 1.5M NH4SO4, 0.1M Sodium citrate
Resolution 3.05 Å R-free 0.292
7CIO Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase Deposited 2020-07-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 199–206（8 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.2 M ammonium acetate, 0.1 M sodium acetate trihydrate pH 4.6, 30% PEG 4000
Resolution 1.10 Å R-free 0.179
7DV4 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 Deposited 2021-01-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 36–153（118 aa）
Chain G 36–153（118 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；100 mM sodium citrate, 10% (w/v) PEG 6000, pH 5.0
Resolution 2.38 Å R-free 0.258
7DV4 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 Deposited 2021-01-12 Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 36–153（118 aa）
Chain E 36–153（118 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；100 mM sodium citrate, 10% (w/v) PEG 6000, pH 5.0
Resolution 2.38 Å R-free 0.258
7ELX The crystal structure of CTLA-4 and Fab Deposited 2021-04-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；285 K；PEG8000 10%, 0.1M Na Citrate 0.1M (NH4)2SO4
Resolution 2.14 Å R-free 0.217
7ELX The crystal structure of CTLA-4 and Fab Deposited 2021-04-12 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain c 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；285 K；PEG8000 10%, 0.1M Na Citrate 0.1M (NH4)2SO4
Resolution 2.14 Å R-free 0.217
7SU0 Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 Deposited 2021-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 36–153（118 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M ammonium citrate dibasic, 20% w/v PEG 1,000, pH 5.2
Resolution 2.41 Å R-free 0.264
7SU0 Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 Deposited 2021-11-15 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 36–153（118 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FLC CITRATE ANION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M ammonium citrate dibasic, 20% w/v PEG 1,000, pH 5.2
Resolution 2.41 Å R-free 0.264
7SU1 Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 Deposited 2021-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 36–153（118 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M sodium citrate tribasic dehydrate, 22% PEG 3,350
Resolution 2.53 Å R-free 0.251
8GAB Crystal structure of CTLA-4 in complex with a high affinity CTLA-4 binder Deposited 2023-02-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 36–161（126 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；22% (w/v) PEG 3350 and 0.2 M KCl
Resolution 2.72 Å R-free 0.292
8GAB Crystal structure of CTLA-4 in complex with a high affinity CTLA-4 binder Deposited 2023-02-22 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 36–161（126 aa）
Not recorded K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；22% (w/v) PEG 3350 and 0.2 M KCl
Resolution 2.72 Å R-free 0.292
8HIT Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4 Deposited 2022-11-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 35–154（120 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；291 K；100mM Tris, pH 8.5, 30% w/v PEG 4000
Resolution 3.20 Å R-free 0.298
9DQ3 Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with human CTLA-4 Deposited 2024-09-23 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 36–153（118 aa） Fragment：Extracellular domain of human CTLA-4 with hexahistidine tag
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；300 K；0.18 M calcium acetate hydrate, 22.5% w/v PEG3350
Resolution 1.64 Å R-free 0.268

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.