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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P18564 New Search
14PDB entries
20Biological assembly
21chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4UM8 Crystal structure of alpha V beta 6 Deposited 2014-05-15 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–788（788 aa）
Mutation：YES CL CHLORIDE ION × 1 SO4 SULFATE ION × 3 NI NICKEL (II) ION × 1 CA CALCIUM ION × 5 CAC CACODYLATE ION × 1 MG MAGNESIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；15% PEG 4000, 0.1 M NACACODYLATE, PH 6.0
Resolution 2.85 Å R-free 0.281
4UM8 Crystal structure of alpha V beta 6 Deposited 2014-05-15 Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 1–788（788 aa）
Mutation：YES CL CHLORIDE ION × 2 CA CALCIUM ION × 5 CAC CACODYLATE ION × 1 MG MAGNESIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；15% PEG 4000, 0.1 M NACACODYLATE, PH 6.0
Resolution 2.85 Å R-free 0.281
4UM9 Crystal structure of alpha V beta 6 with peptide Deposited 2014-05-15 Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 18–491（474 aa）
Not recorded SO4 SULFATE ION × 2 CA CALCIUM ION × 6 MG MAGNESIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 MAN alpha-D-mannopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；15% PEG 4000, 0.1 M NACACODYLATE, PH 6.0
Resolution 2.50 Å R-free 0.266
4UM9 Crystal structure of alpha V beta 6 with peptide Deposited 2014-05-15 Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain B 18–491（474 aa）
Not recorded SO4 SULFATE ION × 4 CA CALCIUM ION × 6 MG MAGNESIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；15% PEG 4000, 0.1 M NACACODYLATE, PH 6.0
Resolution 2.50 Å R-free 0.266
5FFG Crystal structure of integrin alpha V beta 6 head Deposited 2015-12-18 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 128–378（251 aa） Fragment：UNP residues 128-378
Not recorded CA CALCIUM ION × 6 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SO4 SULFATE ION × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG3000 20% PEG200 0.1M MES
Resolution 2.25 Å R-free 0.246
5FFO Integrin alpha V beta 6 in complex with pro-TGF-beta Deposited 2015-12-18 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 128–378（251 aa） Fragment：Unp residues 128-378
Chain F 128–378（251 aa） Fragment：Unp residues 128-378
Not recorded CA CALCIUM ION × 8 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 MN MANGANESE (II) ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；8% PEG8000 0.1M Immidazole
Resolution 3.49 Å R-free 0.277
5NEM Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A. Deposited 2017-03-10 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MAN alpha-D-mannopyranose × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 10.80 Å
5NER Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A prime. Deposited 2017-03-11 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MAN alpha-D-mannopyranose × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 11.50 Å
5NET Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose A. Deposited 2017-03-11 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MAN alpha-D-mannopyranose × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.60 Å
5NEU Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B. Deposited 2017-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 360 PDB declaration: 360-meric（360） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MG MAGNESIUM ION × 60 CA CALCIUM ION × 120 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.30 Å
5NEU Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B. Deposited 2017-03-11 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MG MAGNESIUM ION × 1 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.30 Å
5NEU Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B. Deposited 2017-03-11 Assembly 3 Protein heterocomplex Heteromer；Protein × 30 PDB declaration: 30-meric（30） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MG MAGNESIUM ION × 5 CA CALCIUM ION × 10 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.30 Å
5NEU Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B. Deposited 2017-03-11 Assembly 4 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric（36） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MG MAGNESIUM ION × 6 CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.30 Å
5NEU Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B. Deposited 2017-03-11 Assembly 5 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded MG MAGNESIUM ION × 1 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 12.30 Å
8TCG Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf Deposited 2023-06-30 Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain B 130–371（242 aa）
Not recorded CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 MN MANGANESE (II) ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9CZ7 Crystal structure of integrin avb6 headpiece in complex with compound 12 Deposited 2024-08-04 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded CA CALCIUM ION × 6 GOL GLYCEROL × 8 MG MAGNESIUM ION × 1 A1A6A (2S)-phenyl{(3S)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ACT ACETATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；13% PEG 3350, 100 mM HEPES pH 7.1, 200 mM ammonium citrate
Resolution 2.57 Å R-free 0.234
9CZA Crystal structure of integrin avb6 headpiece in complex with compound 18 Deposited 2024-08-05 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded CA CALCIUM ION × 6 MAN alpha-D-mannopyranose × 1 GOL GLYCEROL × 7 MG MAGNESIUM ION × 1 A1A6B (2S)-(2-cyclopropylphenyl){(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ACT ACETATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；13% PEG 3350, 100 mM HEPES pH 7.1, 200 mM ammonium citrate
Resolution 2.49 Å R-free 0.244
9CZD Crystal structure of integrin avb6 headpiece in complex with compound 30 Deposited 2024-08-05 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded CA CALCIUM ION × 6 GOL GLYCEROL × 8 A1A6H (2S)-{5-fluoro-2-[(2S)-oxan-2-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid × 1 MG MAGNESIUM ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ACT ACETATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；13% PEG 3350, 100 mM HEPES pH 7.1, 200 mM ammonium citrate
Resolution 2.23 Å R-free 0.233
9CZF Crystal structure of integrin avb6 headpiece in complex with compound MORF-627 Deposited 2024-08-05 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 22–491（470 aa）
Not recorded CA CALCIUM ION × 6 MAN alpha-D-mannopyranose × 2 GOL GLYCEROL × 8 MG MAGNESIUM ION × 1 A1A6I (2S)-{5-fluoro-2-[(6S)-5-oxaspiro[2.5]octan-6-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid × 1 ACT ACETATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；13% PEG 3350, 100 mM HEPES pH 7.1, 200 mM ammonium citrate
Resolution 2.53 Å R-free 0.245
9XMM Cryo-EM structure of Integrin alpha V beta 6 complex with a bicyclic inhibitory peptide Deposited 2025-11-11 Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain B 18–491（474 aa）
Mutation：I270C CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 MAN alpha-D-mannopyranose × 1 MN MANGANESE (II) ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；pH7.5, contains 0.2 mM CaCl2 and 1 mM MnCl2.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.