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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P18627 New Search
6PDB entries
8Biological assembly
11chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
7TZG Structure of human LAG3 in complex with antibody single-chain variable fragment Deposited 2022-02-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 23–430（408 aa） Fragment：ectodomain
Chain D 23–430（408 aa） Fragment：ectodomain
Mutation：M171I Mutation：M171I NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；1% Tacsimate at pH 5.0, 0.05 M sodium citrate tribasic dihydrate, pH 5.6 and 7% PEG3350
Resolution 3.71 Å R-free 0.275
7TZH Structure of human LAG3 domains 3-4 in complex with antibody single chain-variable fragment Deposited 2022-02-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 261–450（190 aa） Fragment：ectodomain
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；0.1 M HEPES pH 7.1, 13% PEG20000
Resolution 2.43 Å R-free 0.255
7TZH Structure of human LAG3 domains 3-4 in complex with antibody single chain-variable fragment Deposited 2022-02-15 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 261–450（190 aa） Fragment：ectodomain
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；0.1 M HEPES pH 7.1, 13% PEG20000
Resolution 2.43 Å R-free 0.255
7UM3 Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion Deposited 2022-04-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain B 82–97（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Bis-Tris, pH 5.5, 25% PEG3350
Resolution 2.40 Å R-free 0.265
7UM3 Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion Deposited 2022-04-06 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 82–97（16 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Bis-Tris, pH 5.5, 25% PEG3350
Resolution 2.40 Å R-free 0.265
8SO3 CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 Deposited 2023-04-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 1–525（525 aa）
Chain X 1–525（525 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.61 Å
8SR0 CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined Deposited 2023-05-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 1–525（525 aa）
Chain X 1–525（525 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.53 Å
9BF9 Human LAG-3-HLA-DR1 complex Deposited 2024-04-17 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: tetrameric（4） Review required
Chain D 23–429（407 aa）
Not recorded SO4 SULFATE ION × 6 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277.15 K；22% PEG 8000, 0.16M Li2SO4, 0.1M HEPES pH 7.6
Resolution 3.40 Å R-free 0.253

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.