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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P18759 New Search
15PDB entries
17Biological assembly
90chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1CR5 N-TERMINAL DOMAIN OF SEC18P Deposited 1999-08-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 22–210（189 aa） Fragment：N-TERMINAL DOMAIN
Not recorded NEN 1-ETHYL-PYRROLIDINE-2,5-DIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 8000, sodium phosphate, dimethyl sulfoxide, ATP, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 4K
Resolution 2.30 Å R-free 0.277
1CR5 N-TERMINAL DOMAIN OF SEC18P Deposited 1999-08-13 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 22–210（189 aa） Fragment：N-TERMINAL DOMAIN
Not recorded NEN 1-ETHYL-PYRROLIDINE-2,5-DIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 8000, sodium phosphate, dimethyl sulfoxide, ATP, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 4K
Resolution 2.30 Å R-free 0.277
1CR5 N-TERMINAL DOMAIN OF SEC18P Deposited 1999-08-13 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 22–210（189 aa） Fragment：N-TERMINAL DOMAIN
Not recorded NEN 1-ETHYL-PYRROLIDINE-2,5-DIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；PEG 8000, sodium phosphate, dimethyl sulfoxide, ATP, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 4K
Resolution 2.30 Å R-free 0.277
9CRU Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 1 Deposited 2024-07-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.89 Å
9CRX Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 3 Deposited 2024-07-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.73 Å
9N22 Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 2 Deposited 2025-01-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.91 Å
9NG2 Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 4 Deposited 2025-02-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.61 Å
9NLU Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 5 Deposited 2025-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.29 Å
9NLW Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 6 Deposited 2025-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.73 Å
9NLY Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 7 Deposited 2025-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.75 Å
9NLZ Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - Class 8 Deposited 2025-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.13 Å
9NM1 Y20S (Sec18-Sec17-Sec9-Sso1-Snc1) EDTA - All Merge (Class 9, focused on D1/D2) Deposited 2025-03-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 9 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9NUD Y20S after Mg2+ (Sec18) - Class 2 Deposited 2025-03-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded MG MAGNESIUM ION × 6 ADP ADENOSINE-5'-DIPHOSPHATE × 6 ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.38 Å
9NUE Y20S after Mg2+ (Sec18) - Class 3 Deposited 2025-03-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Not recorded MG MAGNESIUM ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 6 ATP ADENOSINE-5'-TRIPHOSPHATE × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.36 Å
9NUZ Y20S after Mg2+ (Sec18) - Class 4 Deposited 2025-03-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Not recorded MG MAGNESIUM ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 7 ATP ADENOSINE-5'-TRIPHOSPHATE × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
9NV0 Sec18 Mg2+ class 2 Deposited 2025-03-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.83 Å
9NV1 Sec18 Mg2+ class 1 Deposited 2025-03-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain A 1–758（758 aa）
Chain B 1–758（758 aa）
Chain C 1–758（758 aa）
Chain D 1–758（758 aa）
Chain E 1–758（758 aa）
Chain F 1–758（758 aa）
Chain G 1–758（758 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 7 ATP ADENOSINE-5'-TRIPHOSPHATE × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.99 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.