当前蛋白身份：P19367
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 1CZA MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP 提交 1999-09-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 N
1–917（917 aa）
|
突变：E280A, R283A, G284Y | GLC alpha-D-glucopyranose × 2 G6P 6-O-phosphono-alpha-D-glucopyranose × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
EVAPORATION；pH 6.5；298 K；PEG 8000, SODIUM ACETATE, MES, ADP, ALUMINUM NITRATE, SODIUM FLUORIDE, MAGNESIUM ACETATE, GLUCOSE, pH 6.5, EVAPORATION, temperature 298.0K
|
分辨率 1.90 Å R-free 0.258 |
| 1DGK MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE 提交 1999-11-24 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 N
1–917（917 aa）
|
突变：E280A, R283A, G284Y, T536A | GLC alpha-D-glucopyranose × 2 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG 8000, SODIUM ACETATE, MES, ADP, GLUCOSE, GLUCOSE-6-PHOSPHATE. GROWN
CRYSTALS WERE SOAKED WITH THE SAME BUFFER, BUT W/O GLUCOSE-6-PHOSPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
分辨率 2.80 Å R-free 0.308 |
| 1HKB CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE 提交 1997-12-01 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 G6P 6-O-phosphono-alpha-D-glucopyranose × 2 CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 5.6；HEXOKINASE WAS CRYSTALLIZED BY MIXING 20 MG/ML OF PROTEIN SOLUTION WITH 6% PEG 8000, 0.1 M NA CITRATE, PH 5.6, 0.1 M NA ACETATE, 20 MM GLUCOSE-6-PHOSPHATE, AND PRESUMABLE TRACE AMOUNT OF GLUCOSE LEFT AFTER PURIFICATION; THEN SOAKED WITH 10 MM G6P AND 5 MM GLUCOSE.
|
分辨率 2.80 Å R-free 0.270 |
| 1HKB CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE 提交 1997-12-01 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 G6P 6-O-phosphono-alpha-D-glucopyranose × 2 CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 5.6；HEXOKINASE WAS CRYSTALLIZED BY MIXING 20 MG/ML OF PROTEIN SOLUTION WITH 6% PEG 8000, 0.1 M NA CITRATE, PH 5.6, 0.1 M NA ACETATE, 20 MM GLUCOSE-6-PHOSPHATE, AND PRESUMABLE TRACE AMOUNT OF GLUCOSE LEFT AFTER PURIFICATION; THEN SOAKED WITH 10 MM G6P AND 5 MM GLUCOSE.
|
分辨率 2.80 Å R-free 0.270 |
| 1HKC RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE 提交 1998-07-01 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 PO4 PHOSPHATE ION × 4 K POTASSIUM ION × 4 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 6.5；HEXOKINASE WAS CRYSTALLIZED BY HANGING DROP METHOD AT ROOM TEMPERATURE BY MIXING 20 MG/ ML OF PROTEIN IN 25 MM POTASSIUM PHOSPHATE WITH A PRECIPITANT SOLUTION CONTAINING 5% PEG 8000 AND 0.1 M NA CACODYLATE, PH 6.5. PROTEIN SAMPLES CONTAINED A TRACE AMOUNT OF GLUCOSE LEFT AFTER PURIFICATION.
|
分辨率 2.80 Å R-free 0.241 |
| 1QHA HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP 提交 1999-05-11 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–917（917 aa）
链 B
1–917（917 aa）
|
未记录 | GLC alpha-D-glucopyranose × 4 G6P 6-O-phosphono-alpha-D-glucopyranose × 4 MG MAGNESIUM ION × 6 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
pH 6.5；pH 6.5
|
分辨率 2.25 Å R-free 0.279 |
| 4F9O Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate 提交 2012-05-19 | Assembly 1 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–914（914 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 0NZ 2-deoxy-6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.65 Å R-free 0.258 |
| 4F9O Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate 提交 2012-05-19 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–914（914 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 0NZ 2-deoxy-6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.65 Å R-free 0.258 |
| 4FOE Crystal Structure of recombinant human Hexokinase type I with Mannose 6-Phosphate 提交 2012-06-20 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–917（917 aa）
链 B
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 4 M6D 6-O-phosphono-beta-D-mannopyranose × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.70 Å R-free 0.254 |
| 4FOI Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate 提交 2012-06-20 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–917（917 aa）
链 B
1–917（917 aa）
|
突变：D413N 突变：D413N | BGC beta-D-glucopyranose × 4 G16 1,6-di-O-phosphono-alpha-D-glucopyranose × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.40 Å R-free 0.273 |
| 4FOI Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate 提交 2012-06-20 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–917（917 aa）
|
突变：D413N | BGC beta-D-glucopyranose × 2 G16 1,6-di-O-phosphono-alpha-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.40 Å R-free 0.273 |
| 4FOI Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate 提交 2012-06-20 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–917（917 aa）
|
突变：D413N | BGC beta-D-glucopyranose × 2 G16 1,6-di-O-phosphono-alpha-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.40 Å R-free 0.273 |
| 4FPA Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate 提交 2012-06-21 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–917（917 aa）
链 B
1–917（917 aa）
|
突变：D413N 突变：D413N | BGC beta-D-glucopyranose × 4 BG6 6-O-phosphono-beta-D-glucopyranose × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.48 Å R-free 0.256 |
| 4FPA Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate 提交 2012-06-21 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–917（917 aa）
|
突变：D413N | BGC beta-D-glucopyranose × 2 BG6 6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.48 Å R-free 0.256 |
| 4FPA Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate 提交 2012-06-21 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–917（917 aa）
|
突变：D413N | BGC beta-D-glucopyranose × 2 BG6 6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 2.48 Å R-free 0.256 |
| 4FPB Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate 提交 2012-06-21 | Assembly 1 蛋白同源多聚体 同源多聚体；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
1–917（917 aa）
链 B
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 4 0WK 1,5-anhydro-6-O-phosphono-D-glucitol × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 3.00 Å R-free 0.256 |
| 4FPB Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate 提交 2012-06-21 | Assembly 2 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 A
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 0WK 1,5-anhydro-6-O-phosphono-D-glucitol × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 3.00 Å R-free 0.256 |
| 4FPB Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate 提交 2012-06-21 | Assembly 3 蛋白单体 单体；蛋白 × 1 PDB 声明：monomeric（1） 与蛋白数一致 |
链 B
1–917（917 aa）
|
未记录 | BGC beta-D-glucopyranose × 2 0WK 1,5-anhydro-6-O-phosphono-D-glucitol × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
|
分辨率 3.00 Å R-free 0.256 |