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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P19367 New Search
10PDB entries
18Biological assembly
23chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1CZA MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP Deposited 1999-09-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain N 1–917（917 aa）
Mutation：E280A, R283A, G284Y GLC alpha-D-glucopyranose × 2 G6P 6-O-phosphono-alpha-D-glucopyranose × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 6.5；298 K；PEG 8000, SODIUM ACETATE, MES, ADP, ALUMINUM NITRATE, SODIUM FLUORIDE, MAGNESIUM ACETATE, GLUCOSE, pH 6.5, EVAPORATION, temperature 298.0K
Resolution 1.90 Å R-free 0.258
1DGK MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE Deposited 1999-11-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain N 1–917（917 aa）
Mutation：E280A, R283A, G284Y, T536A GLC alpha-D-glucopyranose × 2 PO4 PHOSPHATE ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；PEG 8000, SODIUM ACETATE, MES, ADP, GLUCOSE, GLUCOSE-6-PHOSPHATE. GROWN CRYSTALS WERE SOAKED WITH THE SAME BUFFER, BUT W/O GLUCOSE-6-PHOSPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.80 Å R-free 0.308
1HKB CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE Deposited 1997-12-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 2 G6P 6-O-phosphono-alpha-D-glucopyranose × 2 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.6；HEXOKINASE WAS CRYSTALLIZED BY MIXING 20 MG/ML OF PROTEIN SOLUTION WITH 6% PEG 8000, 0.1 M NA CITRATE, PH 5.6, 0.1 M NA ACETATE, 20 MM GLUCOSE-6-PHOSPHATE, AND PRESUMABLE TRACE AMOUNT OF GLUCOSE LEFT AFTER PURIFICATION; THEN SOAKED WITH 10 MM G6P AND 5 MM GLUCOSE.
Resolution 2.80 Å R-free 0.270
1HKB CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE Deposited 1997-12-01 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 2 G6P 6-O-phosphono-alpha-D-glucopyranose × 2 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.6；HEXOKINASE WAS CRYSTALLIZED BY MIXING 20 MG/ML OF PROTEIN SOLUTION WITH 6% PEG 8000, 0.1 M NA CITRATE, PH 5.6, 0.1 M NA ACETATE, 20 MM GLUCOSE-6-PHOSPHATE, AND PRESUMABLE TRACE AMOUNT OF GLUCOSE LEFT AFTER PURIFICATION; THEN SOAKED WITH 10 MM G6P AND 5 MM GLUCOSE.
Resolution 2.80 Å R-free 0.270
1HKC RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE Deposited 1998-07-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 2 PO4 PHOSPHATE ION × 4 K POTASSIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；HEXOKINASE WAS CRYSTALLIZED BY HANGING DROP METHOD AT ROOM TEMPERATURE BY MIXING 20 MG/ ML OF PROTEIN IN 25 MM POTASSIUM PHOSPHATE WITH A PRECIPITANT SOLUTION CONTAINING 5% PEG 8000 AND 0.1 M NA CACODYLATE, PH 6.5. PROTEIN SAMPLES CONTAINED A TRACE AMOUNT OF GLUCOSE LEFT AFTER PURIFICATION.
Resolution 2.80 Å R-free 0.241
1QHA HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP Deposited 1999-05-11 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–917（917 aa）
Chain B 1–917（917 aa）
Not recorded GLC alpha-D-glucopyranose × 4 G6P 6-O-phosphono-alpha-D-glucopyranose × 4 MG MAGNESIUM ION × 6 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；pH 6.5
Resolution 2.25 Å R-free 0.279
4F9O Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate Deposited 2012-05-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–914（914 aa）
Not recorded BGC beta-D-glucopyranose × 2 0NZ 2-deoxy-6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.65 Å R-free 0.258
4F9O Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate Deposited 2012-05-19 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–914（914 aa）
Not recorded BGC beta-D-glucopyranose × 2 0NZ 2-deoxy-6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.65 Å R-free 0.258
4FOE Crystal Structure of recombinant human Hexokinase type I with Mannose 6-Phosphate Deposited 2012-06-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–917（917 aa）
Chain B 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 4 M6D 6-O-phosphono-beta-D-mannopyranose × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.70 Å R-free 0.254
4FOI Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate Deposited 2012-06-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–917（917 aa）
Chain B 1–917（917 aa）
Mutation：D413N Mutation：D413N BGC beta-D-glucopyranose × 4 G16 1,6-di-O-phosphono-alpha-D-glucopyranose × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.40 Å R-free 0.273
4FOI Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate Deposited 2012-06-20 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–917（917 aa）
Mutation：D413N BGC beta-D-glucopyranose × 2 G16 1,6-di-O-phosphono-alpha-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.40 Å R-free 0.273
4FOI Crystal Structure of recombinant human Hexokinase type I mutant D413N with Glucose 1,6-bisphosphate Deposited 2012-06-20 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–917（917 aa）
Mutation：D413N BGC beta-D-glucopyranose × 2 G16 1,6-di-O-phosphono-alpha-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.40 Å R-free 0.273
4FPA Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate Deposited 2012-06-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–917（917 aa）
Chain B 1–917（917 aa）
Mutation：D413N Mutation：D413N BGC beta-D-glucopyranose × 4 BG6 6-O-phosphono-beta-D-glucopyranose × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.48 Å R-free 0.256
4FPA Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate Deposited 2012-06-21 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–917（917 aa）
Mutation：D413N BGC beta-D-glucopyranose × 2 BG6 6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.48 Å R-free 0.256
4FPA Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate Deposited 2012-06-21 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–917（917 aa）
Mutation：D413N BGC beta-D-glucopyranose × 2 BG6 6-O-phosphono-beta-D-glucopyranose × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 2.48 Å R-free 0.256
4FPB Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate Deposited 2012-06-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–917（917 aa）
Chain B 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 4 0WK 1,5-anhydro-6-O-phosphono-D-glucitol × 4 NA SODIUM ION × 4 CIT CITRIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 3.00 Å R-free 0.256
4FPB Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate Deposited 2012-06-21 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 2 0WK 1,5-anhydro-6-O-phosphono-D-glucitol × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 3.00 Å R-free 0.256
4FPB Crystal Structure of Recombinant Human Hexokinase Type I with 1,5-Anhydroglucitol 6-Phosphate Deposited 2012-06-21 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–917（917 aa）
Not recorded BGC beta-D-glucopyranose × 2 0WK 1,5-anhydro-6-O-phosphono-D-glucitol × 2 NA SODIUM ION × 2 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6；277 K；PEG 4000, PEG 8000, sodium acetate, sodium citrate, pH 6.0, hanging drop, temperature 277K
Resolution 3.00 Å R-free 0.256

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.