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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P20936 New Search
15PDB entries
27Biological assembly
29chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1WER RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP Deposited 1996-11-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 714–1047（334 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 714 - 1047
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；SEE REFERENCE 1, pH 6.5
Resolution 1.60 Å R-free 0.271
1WQ1 RAS-RASGAP COMPLEX Deposited 1997-07-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 714–1047（334 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 714 - 1047
Not recorded MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 AF3 ALUMINUM FLUORIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 8；SEE REF. DESCRIBING THE STRUCTURE, pH 8.
Resolution 2.50 Å R-free 0.319
2GQI Solution structure of the SH3 domain of human Ras GTPase-activating protein 1 Deposited 2006-04-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 282–339（58 aa） Fragment：SH3 domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient
NMR sample composition 1.17mM 13C, 15N-labeled protein; 20mM d-Tris-HCl (pH 7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3, 10% D2O; 90% H2O | 10% D2O; 90% H2O
Resolution not provided
2GSB Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 Deposited 2006-04-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 341–446（106 aa） Fragment：SH2 domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；293 K；Ionic strength (raw mmCIF value) 120 mM；Pressure ambient
NMR sample composition 1.27mM 13C, 15N-labeled protein; 20mM d-Tris-HCl (pH 7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3, 10% D2O; 90% H2O | 10% D2O; 90% H2O
Resolution not provided
2J05 Crystal structure of the RasGAP SH3 domain at 1.5 Angstrom resolution Deposited 2006-08-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 281–341（61 aa） Fragment：SH3 DOMAIN, RESIDUES 281-341
Chain B 281–341（61 aa） Fragment：SH3 DOMAIN, RESIDUES 281-341
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；100 MM KNO3, 100 MM TAPS, PH 9 AND 40% PEG 8000
Resolution 1.50 Å R-free 0.199
2J06 Crystal structure of the RasGAP SH3 domain at 1.8 Angstrom resolution Deposited 2006-08-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 281–341（61 aa） Fragment：SH3 DOMAIN, RESIDUES 281-341
Chain B 281–341（61 aa） Fragment：SH3 DOMAIN, RESIDUES 281-341
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 9；90 MM KNO3, 15.5% GLYCEROL, 90 MM TAPS, PH 9 AND 45.5% PEG8000
Resolution 1.80 Å R-free 0.240
2M51 NMR structure of the SH3 domain of human RAS p21 protein activator (GTPase activating protein) 1 Deposited 2013-02-12 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 281–341（61 aa） Fragment：UNP residues 281-341
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；298 K；Ionic strength (raw mmCIF value) 0.798；Pressure ambient
NMR sample composition 1.2 mM [U-98% 13C; U-98% 15N] protein, 20 mM sodium phosphate, 50 mM sodium chloride, 5 mM sodium azide, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
4FSS Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution Deposited 2012-06-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 281–341（61 aa） Fragment：SH3 domain residues 281-341
Non-standard monomer：Yes (specific site not provided by mmCIF) PO4 PHOSPHATE ION × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；20.00% Glycerol, 1.600M NH4H2PO4, 0.1M TRIS pH 8.5, NANODROP, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.25 Å R-free 0.237
4FSS Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution Deposited 2012-06-27 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 281–341（61 aa） Fragment：SH3 domain residues 281-341
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；20.00% Glycerol, 1.600M NH4H2PO4, 0.1M TRIS pH 8.5, NANODROP, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.25 Å R-free 0.237
4FSS Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution Deposited 2012-06-27 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 281–341（61 aa） Fragment：SH3 domain residues 281-341
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；277 K；20.00% Glycerol, 1.600M NH4H2PO4, 0.1M TRIS pH 8.5, NANODROP, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.25 Å R-free 0.237
6PXB N-Terminal SH2 domain of the p120RasGAP Deposited 2019-07-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain F 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；21% PEG 10,000 0.1M Tris pH 8.0 0.2M Ammonium Acetate
Resolution 1.75 Å R-free 0.263
6PXB N-Terminal SH2 domain of the p120RasGAP Deposited 2019-07-25 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；21% PEG 10,000 0.1M Tris pH 8.0 0.2M Ammonium Acetate
Resolution 1.75 Å R-free 0.263
6PXB N-Terminal SH2 domain of the p120RasGAP Deposited 2019-07-25 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；21% PEG 10,000 0.1M Tris pH 8.0 0.2M Ammonium Acetate
Resolution 1.75 Å R-free 0.263
6PXB N-Terminal SH2 domain of the p120RasGAP Deposited 2019-07-25 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；21% PEG 10,000 0.1M Tris pH 8.0 0.2M Ammonium Acetate
Resolution 1.75 Å R-free 0.263
6PXB N-Terminal SH2 domain of the p120RasGAP Deposited 2019-07-25 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；21% PEG 10,000 0.1M Tris pH 8.0 0.2M Ammonium Acetate
Resolution 1.75 Å R-free 0.263
6PXB N-Terminal SH2 domain of the p120RasGAP Deposited 2019-07-25 Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；21% PEG 10,000 0.1M Tris pH 8.0 0.2M Ammonium Acetate
Resolution 1.75 Å R-free 0.263
6PXC N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide Deposited 2019-07-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 174–280（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.8M Sodium Malonate 0.1M Bis Tris 6.5 2% PEG MME 550
Resolution 1.60 Å R-free 0.210
6WAX C-terminal SH2 domain of p120RasGAP Deposited 2020-03-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 340–444（105 aa）
Mutation：C372S, C402S SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；2.3 M Ammonium Sulfate, 0.1 M Bis Tris pH 6.5
Resolution 1.50 Å R-free 0.197
6WAX C-terminal SH2 domain of p120RasGAP Deposited 2020-03-26 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 340–444（105 aa）
Mutation：C372S, C402S SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；2.3 M Ammonium Sulfate, 0.1 M Bis Tris pH 6.5
Resolution 1.50 Å R-free 0.197
6WAY C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide Deposited 2020-03-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 340–444（105 aa）
Mutation：C372S, C402S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；1.2 M Sodium citrate tribasic dihydrate, 0.1 M Tris pH 8.5
Resolution 1.50 Å R-free 0.190
8BOS Transition state analogue complex of small G protein and its GAP effector Deposited 2022-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 713–1042（330 aa）
Not recorded GDP GUANOSINE-5'-DIPHOSPHATE × 1 MGF TRIFLUOROMAGNESATE × 1 MG MAGNESIUM ION × 1 GAI GUANIDINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；precipitant: HEPES-Na 100 mM pH = 8.0, PEG3350 22% (w/v), (NH4)2SO4 20 mM, Gd-HCl 100 mM, NaF 20 mM protein buffer: HRas 0.400 mM, RasGAP 0.400 mM, HEPES-Na 20 mM, NaF 20 mM drop size: 5 uL, protein:precipitant ratio: 1:1.2
Resolution 2.10 Å R-free 0.280
8DGQ Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide Deposited 2022-06-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 174–444（271 aa）
Not recorded MLI MALONATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.5 M Sodium Malonate pH 5.0, 0.1 M sodium acetate trihydrate salt, 6% PEG 20,000
Resolution 1.95 Å R-free 0.256
8DGQ Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide Deposited 2022-06-24 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 174–444（271 aa）
Not recorded MLI MALONATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；0.5 M Sodium Malonate pH 5.0, 0.1 M sodium acetate trihydrate salt, 6% PEG 20,000
Resolution 1.95 Å R-free 0.256
9BZ4 Crystal structure of the C2 and GAP domains of human p120RasGAP Deposited 2024-05-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 581–1047（467 aa） Fragment：UNP Residues 581-1047
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.2M Ammonium Phosphate Dibasic 0.1M MOPS pH 7.4 26% w/v PEG 3350
Resolution 2.45 Å R-free 0.284
9BZ4 Crystal structure of the C2 and GAP domains of human p120RasGAP Deposited 2024-05-24 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 581–1047（467 aa） Fragment：UNP Residues 581-1047
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.2M Ammonium Phosphate Dibasic 0.1M MOPS pH 7.4 26% w/v PEG 3350
Resolution 2.45 Å R-free 0.284
9BZ4 Crystal structure of the C2 and GAP domains of human p120RasGAP Deposited 2024-05-24 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 581–1047（467 aa） Fragment：UNP Residues 581-1047
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.2M Ammonium Phosphate Dibasic 0.1M MOPS pH 7.4 26% w/v PEG 3350
Resolution 2.45 Å R-free 0.284
9BZ4 Crystal structure of the C2 and GAP domains of human p120RasGAP Deposited 2024-05-24 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 581–1047（467 aa） Fragment：UNP Residues 581-1047
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.4；298 K；0.2M Ammonium Phosphate Dibasic 0.1M MOPS pH 7.4 26% w/v PEG 3350
Resolution 2.45 Å R-free 0.284

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.