当前蛋白身份：P21279
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差异标签只比较当前检索结果；所有PDB和assembly原始记录仍分别保留。
相关结构差异明细
一行代表一个 PDB 条目中的一个 biological assembly；同一蛋白的多个单体会分别列出。
| PDB 条目 | Assembly / 聚集状态 | 构建体 | 突变与修饰 | 配体、离子与非聚合物 | 实验方法 | 实验环境 | 结构质量 |
|---|---|---|---|---|---|---|---|
| 2BCJ Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits 提交 2005-10-19 | Assembly 1 信息不足 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 Q
37–359（323 aa）
|
未记录 | MG MAGNESIUM ION × 1 ALF TETRAFLUOROALUMINATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；9% PEG8000, 1M NaCl, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
分辨率 3.06 Å R-free 0.292 |
| 3AH8 Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 提交 2010-04-20 | Assembly 1 信息不足 异源复合物；蛋白 × 4 PDB 声明：tetrameric（4） 与蛋白数一致 |
链 A
37–359（323 aa）
片段：UNP entry P10824 residues 2-28, UNP entry P21279 residues 37-359
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION；pH 5.1；293 K；7% PEG 4000, 30% (v/v) glycerol, 70 mM acetate-NaOH, pH 5.1, VAPOR DIFFUSION, temperature 293K
|
分辨率 2.90 Å R-free 0.315 |
| 4EKC Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C) 提交 2012-04-09 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
18–359（342 aa）
片段：UNP residues 18-359
|
突变：E125D, N126V, Y128D, V129Y, D130A, R183C | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；17% PEG 3350, 200 mM NaCl, and 100 mM MES pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
分辨率 7.40 Å R-free 0.220 |
| 4EKC Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C) 提交 2012-04-09 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
18–359（342 aa）
片段：UNP residues 18-359
|
突变：E125D, N126V, Y128D, V129Y, D130A, R183C | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；17% PEG 3350, 200 mM NaCl, and 100 mM MES pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
分辨率 7.40 Å R-free 0.220 |
| 4EKD Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C) 提交 2012-04-09 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
18–359（342 aa）
片段：UNP residues 18-359
|
突变：E125D, N126V, Y128D, V129Y, D130A, R183C | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 CO COBALT (II) ION × 2 CL CHLORIDE ION × 2 MG MAGNESIUM ION × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；12% PEG 8,000, 15 mM CoCl2, 200 mM NaCl, and 100 mM MES 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
分辨率 2.71 Å R-free 0.252 |
| 4GNK Crystal structure of Galphaq in complex with full-length human PLCbeta3 提交 2012-08-17 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
7–359（353 aa）
片段：UNP residues 7-359
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.75；277.15 K；100 mM MES pH 6.75, 100-200 mM NaCl, and 11-12% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
分辨率 4.00 Å R-free 0.255 |
| 4GNK Crystal structure of Galphaq in complex with full-length human PLCbeta3 提交 2012-08-17 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
7–359（353 aa）
片段：UNP residues 7-359
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.75；277.15 K；100 mM MES pH 6.75, 100-200 mM NaCl, and 11-12% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
分辨率 4.00 Å R-free 0.255 |
| 4QJ3 Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq 提交 2014-06-03 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
7–359（353 aa）
片段：UNP residues 7-359
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；277.15 K；100 mM BisTris, 200 mM NaCl, 5% PEG 3350, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
分辨率 3.00 Å R-free 0.240 |
| 4QJ4 Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex with Galphaq 提交 2014-06-03 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
7–359（353 aa）
片段：UNP residues 7-359
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 1 I3P D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；100 mM BisTris, 200 mM NaCl, 8% (v/v) PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
分辨率 3.30 Å R-free 0.267 |
| 4QJ5 Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq 提交 2014-06-03 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
7–359（353 aa）
片段：UNP residues 7-359
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 1 I3P D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6.25；277.15 K；100 mM MES, 200 mM NaCl, 5% (v/v) PEG 3350, pH 6.25, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
分辨率 3.41 Å R-free 0.277 |
| 5DO9 Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 提交 2015-09-10 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
37–350（314 aa）
片段：Guanine nucleotide-binding protein G(q) subunit alpha
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；Ammonium acetate, BisTris pH 5.5, PEG 8000
|
分辨率 2.60 Å R-free 0.226 |
| 5DO9 Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 提交 2015-09-10 | Assembly 2 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
37–350（314 aa）
片段：Guanine nucleotide-binding protein G(q) subunit alpha
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；Ammonium acetate, BisTris pH 5.5, PEG 8000
|
分辨率 2.60 Å R-free 0.226 |
| 5DO9 Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 提交 2015-09-10 | Assembly 3 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 E
37–350（314 aa）
片段：Guanine nucleotide-binding protein G(q) subunit alpha
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；Ammonium acetate, BisTris pH 5.5, PEG 8000
|
分辨率 2.60 Å R-free 0.226 |
| 5DO9 Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 提交 2015-09-10 | Assembly 4 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
37–350（314 aa）
片段：Guanine nucleotide-binding protein G(q) subunit alpha
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；Ammonium acetate, BisTris pH 5.5, PEG 8000
|
分辨率 2.60 Å R-free 0.226 |
| 5DO9 Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 提交 2015-09-10 | Assembly 5 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 C
37–350（314 aa）
片段：Guanine nucleotide-binding protein G(q) subunit alpha
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；Ammonium acetate, BisTris pH 5.5, PEG 8000
|
分辨率 2.60 Å R-free 0.226 |
| 5DO9 Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q 提交 2015-09-10 | Assembly 6 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 E
37–350（314 aa）
片段：Guanine nucleotide-binding protein G(q) subunit alpha
|
未记录 | GDP GUANOSINE-5'-DIPHOSPHATE × 1 ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 5.5；277.15 K；Ammonium acetate, BisTris pH 5.5, PEG 8000
|
分辨率 2.60 Å R-free 0.226 |
| 7SQ2 Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex 提交 2021-11-04 | Assembly 1 蛋白异源复合物 异源复合物；蛋白 × 2 PDB 声明：dimeric（2） 与蛋白数一致 |
链 A
35–359（325 aa）
|
未记录 | ALF TETRAFLUOROALUMINATE ION × 1 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 1 ACT ACETATE ION × 7 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray结晶条件
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；7% PEG 6000, 100 mM Hepes, 1 mM CaCl2, 100 mM magnesium acetate
|
分辨率 2.60 Å R-free 0.263 |