Current Protein Identity：P21860
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1M6B Structure of the HER3 (ERBB3) Extracellular Domain Deposited 2002-07-15 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
20–640（621 aa）
Fragment：Extracellular Domain
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；pH 9.0, VAPOR DIFFUSION, HANGING DROP at 293K
|
Resolution 2.60 Å R-free 0.294 |
| 1M6B Structure of the HER3 (ERBB3) Extracellular Domain Deposited 2002-07-15 | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
20–640（621 aa）
Fragment：Extracellular Domain
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9；293 K；pH 9.0, VAPOR DIFFUSION, HANGING DROP at 293K
|
Resolution 2.60 Å R-free 0.294 |
| 2L9U Spatial structure of dimeric ErbB3 transmembrane domain Deposited 2011-02-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
639–670（32 aa）
Fragment：UNP RESIDUES 640-670
Chain B
639–670（32 aa）
Fragment：UNP RESIDUES 640-670
|
Mutation：K639R Mutation：K639R | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5.5；313 K；Ionic strength (raw mmCIF value) 50；Pressure ambient
NMR sample composition
1 mM [U-100% 13C; U-100% 15N] ErbB3tm-1, 1 mM ErbB3tm-2, 80 mM [U-99% 2H] DPC-3, 1 mM sodium azide-4, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
1 mM [U-100% 13C; U-100% 15N] ErbB3tm-5, 1 mM ErbB3tm-6, 80 mM [U-99% 2H] DPC-7, 1 mM sodium azide-8, 100% D2O | 100% D2O
|
Resolution not provided |
| 3KEX Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) Deposited 2009-10-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
698–1019（322 aa）
Fragment：UNP residues 698-1019
Chain B
698–1019（322 aa）
Fragment：UNP residues 698-1019
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 MG MAGNESIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；5mM AMP-PNP, 2mM MgCl2, 1mM DTT, 1mM TCEP, 0.1M Tris pH8.5, 0.2M lithium sulfate, 25% w/v PEG 3350 supplemented with 0.2% w/v 1,2- Diaminocyclohexane sulfate, 0.2% w/v Diloxanite Furoate, 0.2% w/v Fumaric Acid, 0.2% w/v Spermine, 0.2% w/v Sulfaguanidine, 0.02M Hepes sodium pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.80 Å R-free 0.283 |
| 3KEX Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) Deposited 2009-10-26 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
698–1019（322 aa）
Fragment：UNP residues 698-1019
Chain B
698–1019（322 aa）
Fragment：UNP residues 698-1019
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 MG MAGNESIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；5mM AMP-PNP, 2mM MgCl2, 1mM DTT, 1mM TCEP, 0.1M Tris pH8.5, 0.2M lithium sulfate, 25% w/v PEG 3350 supplemented with 0.2% w/v 1,2- Diaminocyclohexane sulfate, 0.2% w/v Diloxanite Furoate, 0.2% w/v Fumaric Acid, 0.2% w/v Spermine, 0.2% w/v Sulfaguanidine, 0.02M Hepes sodium pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.80 Å R-free 0.283 |
| 3LMG Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP Deposited 2010-01-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
684–1020（337 aa）
Fragment：Tyrosine Kinase Domain (UNP residues 684-1020)
|
Not recorded | MG MAGNESIUM ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；294 K；50 mM MOPS pH7.4, 27% (w/v) PEG8000, 0.17 M ammonium sulfate and 15%(v/v) glycerol in well solution and 5mM MgCl2 and 1mM AMP-PNP in protein solution, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.80 Å R-free 0.285 |
| 3LMG Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP Deposited 2010-01-30 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
684–1020（337 aa）
Fragment：Tyrosine Kinase Domain (UNP residues 684-1020)
|
Not recorded | MG MAGNESIUM ION × 1 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；294 K；50 mM MOPS pH7.4, 27% (w/v) PEG8000, 0.17 M ammonium sulfate and 15%(v/v) glycerol in well solution and 5mM MgCl2 and 1mM AMP-PNP in protein solution, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.80 Å R-free 0.285 |
| 3P11 anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region Deposited 2010-09-29 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
20–532（513 aa）
Fragment：domains I-III, UNP residues 20-532
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；295 K；PEG 1500, pH 9, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 3.70 Å R-free 0.323 |
| 4LEO Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3) Deposited 2013-06-26 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
20–631（612 aa）
Fragment：UNP residues 20-631
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Potassium sodium tartrate tetrahydrate, 20% w/v Polyethylene glycol 3350 , pH pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.64 Å R-free 0.258 |
| 4P59 HER3 extracellular domain in complex with Fab fragment of MOR09825 Deposited 2014-03-15 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
20–646（627 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；100 mM bis-tris pH 6.5, 16% (w/v) PEG 10000
|
Resolution 3.40 Å R-free 0.250 |
| 4RIW Crystal structure of an EGFR/HER3 kinase domain heterodimer Deposited 2014-10-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
698–1020（323 aa）
Fragment：KINASE DOMAIN, UNP residues 698-1020
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；7 mg/mL protein, 0.1M HEPES pH 7.5, 14% PEG-6000, 0.2M magnesium chloride, 2mM AMP-PNP, 1mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 3.10 Å R-free 0.287 |
| 4RIW Crystal structure of an EGFR/HER3 kinase domain heterodimer Deposited 2014-10-07 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
698–1020（323 aa）
Fragment：KINASE DOMAIN, UNP residues 698-1020
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；7 mg/mL protein, 0.1M HEPES pH 7.5, 14% PEG-6000, 0.2M magnesium chloride, 2mM AMP-PNP, 1mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 3.10 Å R-free 0.287 |
| 4RIX Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation Deposited 2014-10-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
698–1020（323 aa）
Fragment：KINASE DOMAIN, UNP residues 698-1020
|
Mutation：Q790R | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；10 mg/mL protein, 0.1M HEPES pH 7.5, 15% PEG-5000 MME, 5mM magnesium chloride, 0.5M ammonium acetate, 2mM AMP-PNP, 1mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 3.10 Å R-free 0.258 |
| 4RIX Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation Deposited 2014-10-07 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
698–1020（323 aa）
Fragment：KINASE DOMAIN, UNP residues 698-1020
|
Mutation：Q790R | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；10 mg/mL protein, 0.1M HEPES pH 7.5, 15% PEG-5000 MME, 5mM magnesium chloride, 0.5M ammonium acetate, 2mM AMP-PNP, 1mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 3.10 Å R-free 0.258 |
| 4RIY Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation Deposited 2014-10-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
698–1020（323 aa）
Fragment：KINASE DOMAIN, UNP residues 698-1020
|
Mutation：E909G | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；10 mg/mL protein, 0.1M HEPES pH 7.5, 15% PEG-5000 MME, 5mM magnesium chloride, 0.5M ammonium acetate, 2mM AMP-PNP, 1mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.98 Å R-free 0.267 |
| 4RIY Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation Deposited 2014-10-07 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
698–1020（323 aa）
Fragment：KINASE DOMAIN, UNP residues 698-1020
|
Mutation：E909G | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 2 ADP ADENOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；10 mg/mL protein, 0.1M HEPES pH 7.5, 15% PEG-5000 MME, 5mM magnesium chloride, 0.5M ammonium acetate, 2mM AMP-PNP, 1mM TCEP, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.98 Å R-free 0.267 |
| 5CUS Crystal Structure of sErbB3-Fab3379 Complex Deposited 2015-07-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
20–641（622 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；PEG 3350, Ammonium Citrate, Sodium Thiocyanate
|
Resolution 3.20 Å R-free 0.278 |
| 5CUS Crystal Structure of sErbB3-Fab3379 Complex Deposited 2015-07-25 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
20–641（622 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；PEG 3350, Ammonium Citrate, Sodium Thiocyanate
|
Resolution 3.20 Å R-free 0.278 |
| 5CUS Crystal Structure of sErbB3-Fab3379 Complex Deposited 2015-07-25 | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
20–641（622 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；PEG 3350, Ammonium Citrate, Sodium Thiocyanate
|
Resolution 3.20 Å R-free 0.278 |
| 5CUS Crystal Structure of sErbB3-Fab3379 Complex Deposited 2015-07-25 | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
20–641（622 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；PEG 3350, Ammonium Citrate, Sodium Thiocyanate
|
Resolution 3.20 Å R-free 0.278 |
| 5O4O HER3 in complex with Fab MF3178 Deposited 2017-05-30 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
1–643（643 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M bis tris propane pH 8.5, 0.2 M potassium thyocianate and 20% w/v PEG 3350
|
Resolution 3.40 Å R-free 0.261 |
| 5O7P HER3 in complex with Fab MF3178 Deposited 2017-06-09 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
1–643（643 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M bis tris propane pH 7.5, 0.15 sodium citrate, 20% w/v PEG 3350
|
Resolution 4.50 Å R-free 0.296 |
| 6KBI Crystal structure of ErbB3 N418Q mutant Deposited 2019-06-25 | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
20–639（620 aa）
Chain B
20–639（620 aa）
|
Mutation：N418Q Mutation：N418Q | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.2 M lithium sulfate, 0.1 M Tris buffer (pH 8.5) and 11% (w/v) PEG4000.
|
Resolution 3.00 Å R-free 0.278 |
| 6OP9 HER3 pseudokinase domain bound to bosutinib Deposited 2019-04-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
674–1001（328 aa）
|
Not recorded | DB8 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；298 K；10% PEG 20000, 0.1M MES, pH 6.7
|
Resolution 2.50 Å R-free 0.230 |
| 7BHE DARPin_D5/Her3 domain 4 complex, monoclinic crystals Deposited 2021-01-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
500–643（144 aa）
|
Not recorded | GOL GLYCEROL × 2 ACT ACETATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.83；293 K；0.1 M Na citrate, 12% PEG4000, 0.2 M Li sulfate
|
Resolution 2.30 Å R-free 0.254 |
| 7BHE DARPin_D5/Her3 domain 4 complex, monoclinic crystals Deposited 2021-01-11 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
500–643（144 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.83；293 K；0.1 M Na citrate, 12% PEG4000, 0.2 M Li sulfate
|
Resolution 2.30 Å R-free 0.254 |
| 7BHF DARPin_D5/Her3 domain 4 complex, orthorhombic crystals Deposited 2021-01-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
441–571（131 aa）
|
Not recorded | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.74；293 K；0.1 M Na citrate, 10% PEG4000, 0.2 M Li sulfate
|
Resolution 2.00 Å R-free 0.243 |
| 7BHF DARPin_D5/Her3 domain 4 complex, orthorhombic crystals Deposited 2021-01-11 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
441–571（131 aa）
|
Not recorded | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.74；293 K；0.1 M Na citrate, 10% PEG4000, 0.2 M Li sulfate
|
Resolution 2.00 Å R-free 0.243 |
| 7D85 Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3 Deposited 2020-10-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
328–519（192 aa）
Fragment：extracellular domain 3
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；0.2M Sodium acetate, 20%(w/v) PEG 3350
|
Resolution 2.50 Å R-free 0.258 |
| 7D85 Crystal structure of anti-ErbB3 Fab ISU104 in complex with human ErbB3 extracellular domain 3 Deposited 2020-10-07 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
328–519（192 aa）
Fragment：extracellular domain 3
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；0.2M Sodium acetate, 20%(w/v) PEG 3350
|
Resolution 2.50 Å R-free 0.258 |
| 7MN5 Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain Deposited 2021-04-30 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1021（1021 aa）
Fragment：Extracellular Domain
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.93 Å |
| 7MN6 Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain Deposited 2021-04-30 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1021（1021 aa）
Fragment：Extracellular Domain
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.09 Å |
| 7MN8 Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab Deposited 2021-04-30 | Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–1021（1021 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 8YRY HER3 in complex with FAb Hu3f8 Deposited 2024-03-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
71–205（135 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.93 Å |
| 9I1Q HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody Deposited 2025-01-16 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
20–643（624 aa）
Chain C
20–643（624 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 11 SCN THIOCYANATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；0.2 M KSCN, 0.1 M BIS-TRIS propane pH 8.5, 14% PEG 3350
|
Resolution 2.80 Å R-free 0.263 |
| 9I1Q HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody Deposited 2025-01-16 | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
20–643（624 aa）
Chain D
20–643（624 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 SCN THIOCYANATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；0.2 M KSCN, 0.1 M BIS-TRIS propane pH 8.5, 14% PEG 3350
|
Resolution 2.80 Å R-free 0.263 |