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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P22001 New Search
16PDB entries
16Biological assembly
69chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4BGC T1 domain of the renal potassium channel Kv1.3 Deposited 2013-03-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 104–204（101 aa） Fragment：T1 DOMAIN, RESIDUES 104-204
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；WE WANTED TO USE THE PROTEIN IN 150 MM POTASSIUM PHOSPHATE BUFFER PH 6.5 IN 5 MM NMR TUBES FOR CHARACTERIZATION USING NMR SPECTROSCOPY. DURING TESTING, WE OBSERVED THE FORMATION OF CRYSTALS IN THE NMR TUBES. AN INITIAL TEST OF THE CRYSTALS SHOWED AN EXCELLENT DIFFRACTION PATTERN, SO WE DECIDED TO CONTINUE WITH CRYSTALLIZATION OPTIMIZATION IN NMR TUBES, RESULTING IN VERY GOOD CRYSTALS
Resolution 1.20 Å R-free 0.205
7EJ1 human voltage-gated potassium channel KV1.3 Deposited 2021-04-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–575（575 aa）
Chain D 1–575（575 aa）
Chain F 1–575（575 aa）
Chain H 1–575（575 aa）
Not recorded NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
7EJ2 human voltage-gated potassium channel KV1.3 H451N mutant Deposited 2021-04-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–575（575 aa）
Chain D 1–575（575 aa）
Chain F 1–575（575 aa）
Chain H 1–575（575 aa）
Mutation：H451N Mutation：H451N Mutation：H451N Mutation：H451N NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7SSV Structure of human Kv1.3 with Fab-ShK fusion Deposited 2021-11-11 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.39 Å
7SSX Structure of human Kv1.3 Deposited 2021-11-11 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.89 Å
7SSY Structure of human Kv1.3 (alternate conformation) Deposited 2021-11-11 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.89 Å
7SSZ Structure of human Kv1.3 with A0194009G09 nanobodies Deposited 2021-11-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
7WF3 Composite map of human Kv1.3 channel in apo state with beta subunits Deposited 2021-12-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 208–493（286 aa） Fragment：TM domain
Chain D 208–493（286 aa） Fragment：TM domain
Chain F 208–493（286 aa） Fragment：TM domain
Chain H 208–493（286 aa） Fragment：TM domain
Chain J 99–204（106 aa） Fragment：T1 domain
Chain N 99–204（106 aa） Fragment：T1 domain
Chain O 99–204（106 aa） Fragment：T1 domain
Chain P 99–204（106 aa） Fragment：T1 domain
Not recorded K POTASSIUM ION × 4 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7WF4 Composite map of human Kv1.3 channel in dalazatide-bound state with beta subunits Deposited 2021-12-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 208–490（283 aa） Fragment：TM domain
Chain D 208–490（283 aa） Fragment：TM domain
Chain F 208–490（283 aa） Fragment：TM domain
Chain H 208–490（283 aa） Fragment：TM domain
Chain J 99–204（106 aa） Fragment：T1 domain
Chain N 99–204（106 aa） Fragment：T1 domain
Chain O 99–204（106 aa） Fragment：T1 domain
Chain P 99–204（106 aa） Fragment：T1 domain
Not recorded NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8DFL Structure of human Kv1.3 with A0194009G09 nanobodies (alternate conformation) Deposited 2022-06-22 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
9CLA Human Kv1.3 mutant-H451V Deposited 2024-07-10 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.97 Å
9CLV Human Kv1.3 mutant-P424G Deposited 2024-07-12 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
9CON Human Kv1.3-H451V with A0194009G09 nanobodies conformation 1 Deposited 2024-07-17 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.06 Å
9CTY Human Kv1.3-H451V with A0194009G09 nanobodies conformation 2 Deposited 2024-07-25 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.03 Å
9EEF Human Kv1.3 mutant - G427H Deposited 2024-11-19 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Mutation：G427H Mutation：G427H Mutation：G427H Mutation：G427H K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.54 Å
9EI0 Human Kv1.3 mutant - G427H with A0194009G09 nanobodies Deposited 2024-11-25 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–575（575 aa）
Chain B 1–575（575 aa）
Chain C 1–575（575 aa）
Chain D 1–575（575 aa）
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.91 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.