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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P26349 New Search
18PDB entries
18Biological assembly
18chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1JRJ Solution structure of exendin-4 in 30-vol% trifluoroethanol Deposited 2001-08-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–39（39 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.9；280 K；Ionic strength (raw mmCIF value) 15mM potassium phosphate；Pressure ambient
NMR sample composition Natural abundance | 2mg/ml in pH 5.9 15mM phosphate buffer with 30 vol-% trifluoroethanol added
Resolution not provided
3C59 Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain Deposited 2008-01-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 56–86（31 aa） Fragment：UNP residues 56-86
Non-standard monomer：Yes (specific site not provided by mmCIF) 10M decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1M Tris-HCl pH 8.5, 0.1M MgCl2, 0.4M MgTartrate, 9mM n-Decyl-beta-D-thiomaltoside, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.30 Å R-free 0.241
3C5T Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain Deposited 2008-02-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 56–86（31 aa） Fragment：UNP residues 56-86
Not recorded 10M decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1M Tris-HCl pH 8.5, 0.1M MgCl2, 0.4M MgTartrate, 9mM n-Decyl-beta-D-thiomaltoside, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.238
5OTT Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs Deposited 2017-08-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 48–86（39 aa）
Mutation：G2HCS, T5HCS Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Imidazole pH 6.5, 1.0 M Sodium acetate trihydrate
Resolution 1.92 Å R-free 0.209
6GDZ exendin-4 based dual GLP-1/glucagon receptor agonist Deposited 2018-04-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 48–86（39 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) EVT (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid × 1 SOLUTION NMR
NMR measurement conditions pH 5；310 K；Ionic strength (raw mmCIF value) 35mM sodium phosphate；Pressure 1
NMR sample composition 5 mg/mL Peptide 5, trifluoroethanol/water | trifluoroethanol/water
Resolution not provided
6GE2 exendin-4 based dual GLP-1/glucagon receptor agonist Deposited 2018-04-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 48–86（39 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) EVT (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid × 1 SOLUTION NMR
NMR measurement conditions pH 5；310 K；Ionic strength (raw mmCIF value) 35mM sodium phosphate；Pressure 1
NMR sample composition 5 mg/mL Peptide 12, trifluoroethanol/water | trifluoroethanol/water
Resolution not provided
7LLL Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein Deposited 2021-02-04 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain P 48–86（39 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
7MLL Solution structure of Exenatide (exendin-4) in 30-vol% trifluoroethanol using CS-Rosetta Deposited 2021-04-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 48–86（39 aa） Fragment：UNP Residue 48-86
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.35；315 K；Ionic strength (raw mmCIF value) 20；Pressure 1
NMR sample composition 13 mM 'NA-' Exenatide (exendin-4), 20 mM 'NA-' sodium phosphate, 30 % v/v [U-99% 2H] TFE, 10 % v/v [U-99% 2H] D2O, 0.01 mg/mL 'NA-' DSS, 60 % H2O/30%Trifluoroethanol/10 % D2O | 60 % H2O/30%Trifluoroethanol/10 % D2O
Resolution not provided
9G0M Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 288K Deposited 2024-07-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；288 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.8 mM polypeptide, 1 % sodium-azide, 1 % DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G0N Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 299K Deposited 2024-07-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；299 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.8 mM non-labelled polypeptide, 1 % non-labelled sodium-azide, 1 % non-labelled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G20 Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 310K Deposited 2024-07-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；310 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.8 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G21 Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 321K Deposited 2024-07-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；321 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.8 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G22 Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bDR) at 277K Deposited 2024-07-10 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.1；277 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.85 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G2N Trp-cage fortified Tc5b-Exenatide chimera ( Ex-4-Tc5bDR) at 288K Deposited 2024-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.1；288 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.85 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G2O Trp-cage fortified Tc5b-Exenatide chimera (Ex-4-Tc5bDR) at 299K Deposited 2024-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.1；299 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.85 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G31 Trp-cage fortified Tc5b-Exenatide chimera (Ex-4-Tc5bDR) at 310K Deposited 2024-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.1；310 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.85 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G32 Trp-cage fortified Tc5b-Exenatide chimera (Ex-4-Tc5bDR) at 321K Deposited 2024-07-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.1；321 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.85 mM non-labeld polypeptide, 1 mM non-labeld sodium azide, 1 % non-labeld DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
9G5P Trp-cage fortified Tc5b-Exenatide chimera (Ex4-Tc5bER) at 277K Deposited 2024-07-17 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–86（25 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；277 K；Ionic strength (raw mmCIF value) n.d.；Pressure 1
NMR sample composition 0.8 mM non-labeled polypeptide, 1 % non-labeled sodium azide, 1 % non-labeled DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.