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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P29973 New Search
19PDB entries
19Biological assembly
69chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
7LFT Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+ Deposited 2021-01-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa）
Chain B 144–690（547 aa）
Chain C 144–690（547 aa）
Chain D 144–690（547 aa）
Not recorded CLR CHOLESTEROL × 8 CPL 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 24 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
7LFW Cryo-EM structure of human cGMP-bound open CNGA1 channel in K+/Ca2+ Deposited 2021-01-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa）
Chain B 144–690（547 aa）
Chain C 144–690（547 aa）
Chain D 144–690（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
7LFX Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+ Deposited 2021-01-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa）
Chain B 144–690（547 aa）
Chain C 144–690（547 aa）
Chain D 144–690（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CA CALCIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7LFY Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+ Deposited 2021-01-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa）
Chain B 144–690（547 aa）
Chain C 144–690（547 aa）
Chain D 144–690（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 NA SODIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
7LG1 Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+ Deposited 2021-01-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa）
Chain B 144–690（547 aa）
Chain C 144–690（547 aa）
Chain D 144–690（547 aa）
Mutation：E365Q Mutation：E365Q Mutation：E365Q Mutation：E365Q PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CA CALCIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
7RH9 Cryo-EM structure of human rod CNGA1/B1 channel in apo state Deposited 2021-07-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å
7RHG Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state Deposited 2021-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded CMP ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
7RHH Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state Deposited 2021-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.31 Å
7RHI Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state Deposited 2021-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.31 Å
7RHJ Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state Deposited 2021-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 5H0 (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
7RHK Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state Deposited 2021-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 5H0 (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.27 Å
7RHL Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil Deposited 2021-07-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 144–690（547 aa） Fragment：UNP residues 144-690
Chain C 144–690（547 aa） Fragment：UNP residues 144-690
Chain D 144–690（547 aa） Fragment：UNP residues 144-690
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.03 Å
9ZPV CNGA1 channel closed state in nanodisc cGMP-free Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 K POTASSIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.07 Å
9ZPW CNGA1 channel intermediate state in nanodisc cGMP-bound Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 K POTASSIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.47 Å
9ZPX CNGA1 channel open state in nanodisc cGMP-bound Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 K POTASSIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.64 Å
9ZPY CNGA1 channel closed state in nanodisc with brain PIP2 cGMP-free Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 K POTASSIUM ION × 5 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.48 Å
9ZPZ CNGA1 channel intermediate state in nanodisc with brain PIP2 cGMP-bound Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 2 K POTASSIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；25 mM HEPES, 150 mM KCl, pH7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.64 Å
9ZQ0 CNGA1 channel closed state in nanodisc with diC8-PIP2 cGMP-free Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 K POTASSIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；25 mM HEPES, 150 mM KCl, pH7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.11 Å
9ZQ1 CNGA1 channel intermediate state in nanodisc with diC8-PIP2 cGMP-bound Deposited 2025-12-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 140–686（547 aa）
Chain B 140–686（547 aa）
Chain C 140–686（547 aa）
Chain D 140–686（547 aa）
Not recorded PCG CYCLIC GUANOSINE MONOPHOSPHATE × 4 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 K POTASSIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；25 mM HEPES, 150 mM KCl, pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.22 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.