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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P42575 New Search
13PDB entries
26Biological assembly
78chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1PYO Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho Deposited 2003-07-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 167–333（167 aa） Fragment：subunit p18, sequence database residues 151-316
Chain B 348–452（105 aa） Fragment：subunit p12, sequence database residues 331-435
Chain C 167–333（167 aa） Fragment：subunit p18, sequence database residues 151-316
Chain D 348–452（105 aa） Fragment：subunit p12, sequence database residues 331-435
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；PEG 6000, MOPS, DTT, SUCROSE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 1.65 Å R-free 0.213
2P2C Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin) Deposited 2007-03-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 167–333（167 aa） Fragment：Residues 167-333
Chain B 348–452（105 aa） Fragment：Residues 348-452
Chain C 167–333（167 aa） Fragment：Residues 167-333
Chain D 348–452（105 aa） Fragment：Residues 348-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；17% PEG 5000-MME, 0.1 M Tris-HOAc, 0.1 M KSCN, 30% ethylene glycol, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.24 Å R-free 0.305
2P2C Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin) Deposited 2007-03-07 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain E 167–333（167 aa） Fragment：Residues 167-333
Chain F 348–452（105 aa） Fragment：Residues 348-452
Chain G 167–333（167 aa） Fragment：Residues 167-333
Chain H 348–452（105 aa） Fragment：Residues 348-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；17% PEG 5000-MME, 0.1 M Tris-HOAc, 0.1 M KSCN, 30% ethylene glycol, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.24 Å R-free 0.305
2P2C Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin) Deposited 2007-03-07 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain I 167–333（167 aa） Fragment：Residues 167-333
Chain J 348–452（105 aa） Fragment：Residues 348-452
Chain K 167–333（167 aa） Fragment：Residues 167-333
Chain L 348–452（105 aa） Fragment：Residues 348-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；17% PEG 5000-MME, 0.1 M Tris-HOAc, 0.1 M KSCN, 30% ethylene glycol, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 3.24 Å R-free 0.305
3R5J Crystal structure of active caspase-2 bound with Ac-ADVAD-CHO Deposited 2011-03-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.77 Å R-free 0.218
3R5J Crystal structure of active caspase-2 bound with Ac-ADVAD-CHO Deposited 2011-03-18 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.77 Å R-free 0.218
3R5J Crystal structure of active caspase-2 bound with Ac-ADVAD-CHO Deposited 2011-03-18 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.77 Å R-free 0.218
3R6G Crystal structure of active caspase-2 bound with Ac-VDVAD-CHO Deposited 2011-03-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.07 Å R-free 0.210
3R6G Crystal structure of active caspase-2 bound with Ac-VDVAD-CHO Deposited 2011-03-21 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.07 Å R-free 0.210
3R6G Crystal structure of active caspase-2 bound with Ac-VDVAD-CHO Deposited 2011-03-21 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.07 Å R-free 0.210
3R6L Caspase-2 T380A bound with Ac-VDVAD-CHO Deposited 2011-03-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Mutation：T380A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.90 Å R-free 0.194
3R6L Caspase-2 T380A bound with Ac-VDVAD-CHO Deposited 2011-03-21 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Mutation：T380A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.90 Å R-free 0.194
3R6L Caspase-2 T380A bound with Ac-VDVAD-CHO Deposited 2011-03-21 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Mutation：T380A Mutation：T380A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.90 Å R-free 0.194
3R7B Caspase-2 bound to one copy of Ac-DVAD-CHO Deposited 2011-03-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES (pH 7.0), 15% PEG 3350, 3mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.80 Å R-free 0.217
3R7N Caspase-2 bound with two copies of Ac-DVAD-CHO Deposited 2011-03-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.33 Å R-free 0.227
3R7N Caspase-2 bound with two copies of Ac-DVAD-CHO Deposited 2011-03-22 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.33 Å R-free 0.227
3R7N Caspase-2 bound with two copies of Ac-DVAD-CHO Deposited 2011-03-22 Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 175–333（159 aa）
Chain B 349–452（104 aa）
Chain C 175–333（159 aa）
Chain D 349–452（104 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.33 Å R-free 0.227
3R7S Crystal Structure of Apo Caspase2 Deposited 2011-03-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 175–333（159 aa） Fragment：UNP residues 175-333
Chain B 349–452（104 aa） Fragment：UNP residues 349-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.25 Å R-free 0.226
3R7S Crystal Structure of Apo Caspase2 Deposited 2011-03-22 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 175–333（159 aa） Fragment：UNP residues 175-333
Chain D 349–452（104 aa） Fragment：UNP residues 349-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.25 Å R-free 0.226
3R7S Crystal Structure of Apo Caspase2 Deposited 2011-03-22 Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 175–333（159 aa） Fragment：UNP residues 175-333
Chain B 349–452（104 aa） Fragment：UNP residues 349-452
Chain C 175–333（159 aa） Fragment：UNP residues 175-333
Chain D 349–452（104 aa） Fragment：UNP residues 349-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1M HEPES, 15% PEG 3350, 3mM DTT, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.25 Å R-free 0.226
3RJM CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c Deposited 2011-04-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 167–333（167 aa） Fragment：Residues 167-333
Chain B 348–452（105 aa） Fragment：Residues 348-452
Chain C 167–333（167 aa） Fragment：Residues 167-333
Chain D 348–452（105 aa） Fragment：Residues 348-452
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；26% PEG 3500, 100MM MES PH 6.5 - PH 7.0, SITTING DROP, VAPOR DIFFUSION, TEMPERATURE 290K, VAPOR DIFFUSION, SITTING DROP
Resolution 2.55 Å R-free 0.249
6S9K Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS Deposited 2019-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 135–168（34 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CFH 1,1,1,3,3,3-hexafluoropropan-2-ol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；PEG 400, calcium chloride, HEPES, 1,1,1,3,3,3-hexafluoropropan-2-ol
Resolution 1.60 Å R-free 0.221
6SAD Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 Deposited 2019-07-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 135–168（34 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293.15 K；PEG 400, magnesium chloride, HEPES, 1,1,1,3,3,3-hexafluoropropan-2-ol
Resolution 2.75 Å R-free 0.271
8VP4 Crystal Structure of JF1cpCasp2 with Peptide Inhibitor AcVDVAD-CHO Deposited 2024-01-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 334–448（115 aa）
Chain A 176–333（158 aa）
Chain B 334–448（115 aa）
Chain B 176–333（158 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；0.1 M Tris, pH 8.0, 0.2 M Sodium chloride, 20% w/v PEG 6000
Resolution 1.51 Å R-free 0.214
9C2Y Crystal Structure of JF1cpCasp2 in complex with MUR-65 Deposited 2024-05-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 334–448（115 aa）
Chain A 177–333（157 aa）
Chain B 334–448（115 aa）
Chain B 177–333（157 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Tris, pH 8.0, 0.2 M Sodium chloride, 20% w/v PEG 6000
Resolution 1.96 Å R-free 0.248
9C2Y Crystal Structure of JF1cpCasp2 in complex with MUR-65 Deposited 2024-05-31 Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 334–448（115 aa）
Chain C 177–333（157 aa）
Chain D 334–448（115 aa）
Chain D 177–333（157 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；0.1 M Tris, pH 8.0, 0.2 M Sodium chloride, 20% w/v PEG 6000
Resolution 1.96 Å R-free 0.248

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.