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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P54132 New Search
13PDB entries
22Biological assembly
31chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2KV2 Solution Structure of the human BLM HRDC domain Deposited 2010-03-04 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1210–1294（85 aa） Fragment：HRDC domain, UNP residues 1210-1294
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100；Pressure 1
NMR sample composition 1mM [U-99% 13C; U-99% 15N] BLM HRDC domain; 1mM DTT; 20mM HEPES; 100mM sodium chloride; 0.02% sodium azide; 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM [U-99% 13C; U-99% 15N] BLM HRDC domain; 1mM DTT; 20mM HEPES; 100mM sodium chloride; 0.02% sodium azide; 100% D2O | 100% D2O
Resolution not provided
2MH9 Resonance assignment of RQC domain of human Bloom syndrome protein Deposited 2013-11-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1067–1210（144 aa） Fragment：UNP RESIDUES 1067-1210
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；300 K；Ionic strength (raw mmCIF value) 0.1；Pressure 1
NMR sample composition 0.8 mM [U-99% 13C; U-99% 15N] BLM RQC-1, 90 % H2O-2, 10 % D2O-3, 1 mM DTT-4, 20 mM Tris-5, 100 mM Sodium Chloride-6, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2RRD Structure of HRDC domain from human Bloom syndrome protein, BLM Deposited 2010-07-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1200–1295（96 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.5；303 K；Ionic strength (raw mmCIF value) 100；Pressure ambient
NMR sample composition 0.5mM [U-98% 13C; U-98% 15N] BLM-1, 50mM TRIS-2, 100mM sodium chloride-3, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM [U-100% 15N] BLM-4, 50mM d11-TRIS-5, 100mM sodium chloride-6, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM [U-98% 13C; U-98% 15N] BLM-7, 50mM d11-TRIS-8, 100mM sodium chloride-9, 100% D2O | 100% D2O
Resolution not provided
3WE2 Structure of BLM RQC domain bound to a phosphate ion Deposited 2013-06-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1068–1209（142 aa） Fragment：RecQ C-terminal (RQC) domain, UNP residues 1068-1209
Not recorded PO4 PHOSPHATE ION × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.4；293 K；20-25% PEG 4000, 50mM sodium phosphate, 150mM sodium acetate, 100mM Tris-HCl, 15%(v/v) glycerol, pH 8.4, VAPOR DIFFUSION, temperature 293K
Resolution 2.70 Å R-free 0.271
3WE2 Structure of BLM RQC domain bound to a phosphate ion Deposited 2013-06-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1068–1209（142 aa） Fragment：RecQ C-terminal (RQC) domain, UNP residues 1068-1209
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.4；293 K；20-25% PEG 4000, 50mM sodium phosphate, 150mM sodium acetate, 100mM Tris-HCl, 15%(v/v) glycerol, pH 8.4, VAPOR DIFFUSION, temperature 293K
Resolution 2.70 Å R-free 0.271
3WE3 Structure of BLM RQC domain bound to an arsenate ion Deposited 2013-06-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1068–1209（142 aa） Fragment：RecQ C-terminal (RQC) domain, UNP residues 1068-1209
Not recorded ART ARSENATE × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.4；293 K；20-25% PEG 4000, 50mM sodium phosphate, 150mM sodium acetate, 100mM Tris-HCl, 15%(v/v) glycerol, pH 8.4, VAPOR DIFFUSION, temperature 293K
Resolution 2.90 Å R-free 0.295
3WE3 Structure of BLM RQC domain bound to an arsenate ion Deposited 2013-06-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1068–1209（142 aa） Fragment：RecQ C-terminal (RQC) domain, UNP residues 1068-1209
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.4；293 K；20-25% PEG 4000, 50mM sodium phosphate, 150mM sodium acetate, 100mM Tris-HCl, 15%(v/v) glycerol, pH 8.4, VAPOR DIFFUSION, temperature 293K
Resolution 2.90 Å R-free 0.295
4CDG Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody Deposited 2013-10-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 636–1298（663 aa） Fragment：CATALYTIC CORE, RESIDUES 636-1298
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 0.1M MES PH 6.0, 22% PEG 20K
Resolution 2.79 Å R-free 0.245
4CDG Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody Deposited 2013-10-31 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 636–1298（663 aa） Fragment：CATALYTIC CORE, RESIDUES 636-1298
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 0.1M MES PH 6.0, 22% PEG 20K
Resolution 2.79 Å R-free 0.245
4CGZ Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA Deposited 2013-11-27 Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 636–1298（663 aa） Fragment：CATALYTIC CORE, RESIDUES 636-1298
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 21% PEG 4000, 0.1M HEPES PH 7.6, 5% 2-PROPANOL
Resolution 3.20 Å R-free 0.259
4O3M Ternary complex of Bloom's syndrome helicase Deposited 2013-12-18 Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 640–1298（659 aa）
Not recorded CA CALCIUM ION × 1 ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 EDO 1,2-ETHANEDIOL × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；6-10% Isopropanol, 50mM MES, 10mM magnesium chloride., pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.30 Å R-free 0.215
5MK5 Structures of DHBN domain of human BLM helicase Deposited 2016-12-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 362–414（53 aa） Fragment：UNP residues 362-414
Chain B 362–414（53 aa） Fragment：UNP residues 362-414
Not recorded IOD IODIDE ION × 9 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；298 K；Tris-HCl 0.1M pH8.5 PEG 1500 26% Glycerol 16%
Resolution 2.16 Å R-free 0.297
5MK5 Structures of DHBN domain of human BLM helicase Deposited 2016-12-02 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 362–414（53 aa） Fragment：UNP residues 362-414
Chain D 362–414（53 aa） Fragment：UNP residues 362-414
Not recorded IOD IODIDE ION × 11 K POTASSIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；298 K；Tris-HCl 0.1M pH8.5 PEG 1500 26% Glycerol 16%
Resolution 2.16 Å R-free 0.297
7AUC Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomer（1） Consistent with protein count
Chain A 636–1070（435 aa）
Chain A 1202–1298（97 aa）
Not recorded ACT ACETATE ION × 4 EDO 1,2-ETHANEDIOL × 6 PG4 TETRAETHYLENE GLYCOL × 2 GOL GLYCEROL × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 2 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；277.15 K；Morpheus-HT, condition A8, Molecular Dimensions 0.06 M divalents, 37.5% Buffer System 2 and 37.5% Precipitant Mix 4 Divalents = 0.3M magnesium chloride, 0.3M calcium chloride Buffer system 2 = 1M sodium HEPES, MOPS (acid) pH 7.5 75% Precipitant Mix 4 = 25% w/v MPD, 25% v/v PEG1000, 25% w/v PEG 3350
Resolution 1.53 Å R-free 0.208
7AUD Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: protein:DNA complex（2） Consistent with all polymers
Chain F 636–1070（435 aa）
Chain F 1202–1298（97 aa）
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 RY8 N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；Morpheus HT-96, Condition C9, Molecular Dimensions. 0.09 M NPS, 0.1M Buffer System, 30% Precipitant Mix 1 NPS = 0.3 M sodium nitrate, 0.3 M sodium phosphate dibasic, 0.3 M ammonium sulphate Buffer System 1 = 1.0 M imidazole, MES monohydrate (acid) pH 6.5 60% Precipitant Mix 1 = 40% v/v PEG 500 MME, 20% w/v PEG 20000
Resolution 2.96 Å R-free 0.269
7AUD Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: protein:DNA complex（2） Consistent with all polymers
Chain A 636–1070（435 aa）
Chain A 1202–1298（97 aa）
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 RY8 N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide × 1 PG4 TETRAETHYLENE GLYCOL × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；Morpheus HT-96, Condition C9, Molecular Dimensions. 0.09 M NPS, 0.1M Buffer System, 30% Precipitant Mix 1 NPS = 0.3 M sodium nitrate, 0.3 M sodium phosphate dibasic, 0.3 M ammonium sulphate Buffer System 1 = 1.0 M imidazole, MES monohydrate (acid) pH 6.5 60% Precipitant Mix 1 = 40% v/v PEG 500 MME, 20% w/v PEG 20000
Resolution 2.96 Å R-free 0.269
7AUD Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 3 Protein–DNA Monomer；Protein × 1 PDB declaration: protein:DNA complex（2） Consistent with all polymers
Chain B 636–1070（435 aa）
Chain B 1202–1298（97 aa）
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 RY8 N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide × 1 PG4 TETRAETHYLENE GLYCOL × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；Morpheus HT-96, Condition C9, Molecular Dimensions. 0.09 M NPS, 0.1M Buffer System, 30% Precipitant Mix 1 NPS = 0.3 M sodium nitrate, 0.3 M sodium phosphate dibasic, 0.3 M ammonium sulphate Buffer System 1 = 1.0 M imidazole, MES monohydrate (acid) pH 6.5 60% Precipitant Mix 1 = 40% v/v PEG 500 MME, 20% w/v PEG 20000
Resolution 2.96 Å R-free 0.269
7AUD Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 4 Protein–DNA Monomer；Protein × 1 PDB declaration: protein:DNA complex（2） Consistent with all polymers
Chain C 636–1070（435 aa）
Chain C 1202–1298（97 aa）
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 RY8 N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide × 1 PG4 TETRAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；Morpheus HT-96, Condition C9, Molecular Dimensions. 0.09 M NPS, 0.1M Buffer System, 30% Precipitant Mix 1 NPS = 0.3 M sodium nitrate, 0.3 M sodium phosphate dibasic, 0.3 M ammonium sulphate Buffer System 1 = 1.0 M imidazole, MES monohydrate (acid) pH 6.5 60% Precipitant Mix 1 = 40% v/v PEG 500 MME, 20% w/v PEG 20000
Resolution 2.96 Å R-free 0.269
7AUD Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 5 Protein–DNA Monomer；Protein × 1 PDB declaration: protein:DNA complex（2） Consistent with all polymers
Chain D 636–1070（435 aa）
Chain D 1202–1298（97 aa）
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 RY8 N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide × 1 PG4 TETRAETHYLENE GLYCOL × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；Morpheus HT-96, Condition C9, Molecular Dimensions. 0.09 M NPS, 0.1M Buffer System, 30% Precipitant Mix 1 NPS = 0.3 M sodium nitrate, 0.3 M sodium phosphate dibasic, 0.3 M ammonium sulphate Buffer System 1 = 1.0 M imidazole, MES monohydrate (acid) pH 6.5 60% Precipitant Mix 1 = 40% v/v PEG 500 MME, 20% w/v PEG 20000
Resolution 2.96 Å R-free 0.269
7AUD Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) Deposited 2020-11-02 Assembly 6 Protein–DNA Monomer；Protein × 1 PDB declaration: protein:DNA complex（2） Consistent with all polymers
Chain E 636–1070（435 aa）
Chain E 1202–1298（97 aa）
Not recorded ZN ZINC ION × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 RY8 N-(2,3-dimethyl-5-sulfamoylphenyl)-4-(2-methylthiazol-4-yl)benzamide × 1 PG4 TETRAETHYLENE GLYCOL × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；Morpheus HT-96, Condition C9, Molecular Dimensions. 0.09 M NPS, 0.1M Buffer System, 30% Precipitant Mix 1 NPS = 0.3 M sodium nitrate, 0.3 M sodium phosphate dibasic, 0.3 M ammonium sulphate Buffer System 1 = 1.0 M imidazole, MES monohydrate (acid) pH 6.5 60% Precipitant Mix 1 = 40% v/v PEG 500 MME, 20% w/v PEG 20000
Resolution 2.96 Å R-free 0.269
7XUW Crystal structure of RPA70N-BLMp2 fusion Deposited 2022-05-20 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 550–570（21 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.6；278 K；8% PEG 4000
Resolution 1.80 Å R-free 0.217
7XV0 Crystal structure of RPA70N-BLMp1 fusion Deposited 2022-05-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 146–165（20 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；278 K；2000 mM Ammonium sulfate
Resolution 1.50 Å R-free 0.200

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.