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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P58004 New Search
6PDB entries
25Biological assembly
29chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5CUF X-ray crystal structure of SeMet human Sestrin2 Deposited 2015-07-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–480（480 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1 M MES 1.15 M sodium malonate
Resolution 3.50 Å R-free 0.272
5CUF X-ray crystal structure of SeMet human Sestrin2 Deposited 2015-07-24 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–480（480 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1 M MES 1.15 M sodium malonate
Resolution 3.50 Å R-free 0.272
5CUF X-ray crystal structure of SeMet human Sestrin2 Deposited 2015-07-24 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–480（480 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1 M MES 1.15 M sodium malonate
Resolution 3.50 Å R-free 0.272
5CUF X-ray crystal structure of SeMet human Sestrin2 Deposited 2015-07-24 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–480（480 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1 M MES 1.15 M sodium malonate
Resolution 3.50 Å R-free 0.272
5CUF X-ray crystal structure of SeMet human Sestrin2 Deposited 2015-07-24 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 1–480（480 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1 M MES 1.15 M sodium malonate
Resolution 3.50 Å R-free 0.272
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 6 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–480（480 aa）
Not recorded LEU LEUCINE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 7 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain B 1–480（480 aa）
Not recorded LEU LEUCINE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5DJ4 Leucine-bound Sestrin2 from Homo sapiens Deposited 2015-09-01 Assembly 8 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 1–480（480 aa）
Chain D 1–480（480 aa）
Chain E 1–480（480 aa）
Not recorded LEU LEUCINE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；1.2 M disodium malonate, 0.1 M MES pH 6.0, 1% (v/v) Jeffamine ED 2001
Resolution 2.70 Å R-free 0.223
5T0N Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution Deposited 2016-08-16 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291.15 K；0.1 M MES pH 6.0, 1.2 M sodium malonate, 1% (w/v) Jeffamine ED 2001
Resolution 3.00 Å R-free 0.225
5T0N Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution Deposited 2016-08-16 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291.15 K；0.1 M MES pH 6.0, 1.2 M sodium malonate, 1% (w/v) Jeffamine ED 2001
Resolution 3.00 Å R-free 0.225
5T0N Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution Deposited 2016-08-16 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291.15 K；0.1 M MES pH 6.0, 1.2 M sodium malonate, 1% (w/v) Jeffamine ED 2001
Resolution 3.00 Å R-free 0.225
5T0N Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution Deposited 2016-08-16 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291.15 K；0.1 M MES pH 6.0, 1.2 M sodium malonate, 1% (w/v) Jeffamine ED 2001
Resolution 3.00 Å R-free 0.225
5T0N Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution Deposited 2016-08-16 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 1–480（480 aa）
Not recorded LEU LEUCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291.15 K；0.1 M MES pH 6.0, 1.2 M sodium malonate, 1% (w/v) Jeffamine ED 2001
Resolution 3.00 Å R-free 0.225
6N0M CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138 Deposited 2018-11-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 66–480（415 aa）
Not recorded K94 4-(difluoromethyl)-L-leucine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.35M Na malonate pH 6.5, 0.1M Mes pH 6.0
Resolution 3.30 Å R-free 0.250
6N0M CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138 Deposited 2018-11-07 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 66–480（415 aa）
Not recorded K94 4-(difluoromethyl)-L-leucine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.35M Na malonate pH 6.5, 0.1M Mes pH 6.0
Resolution 3.30 Å R-free 0.250
6N0M CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138 Deposited 2018-11-07 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 66–480（415 aa）
Not recorded K94 4-(difluoromethyl)-L-leucine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.35M Na malonate pH 6.5, 0.1M Mes pH 6.0
Resolution 3.30 Å R-free 0.250
6N0M CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138 Deposited 2018-11-07 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 66–480（415 aa）
Not recorded K94 4-(difluoromethyl)-L-leucine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.35M Na malonate pH 6.5, 0.1M Mes pH 6.0
Resolution 3.30 Å R-free 0.250
6N0M CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138 Deposited 2018-11-07 Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain E 66–480（415 aa）
Not recorded K94 4-(difluoromethyl)-L-leucine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.35M Na malonate pH 6.5, 0.1M Mes pH 6.0
Resolution 3.30 Å R-free 0.250
9LVJ Cryo-EM structure of Sestrin2 bound human GATOR2 complex Deposited 2025-02-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain U 1–480（480 aa）
Chain V 1–480（480 aa）
Not recorded ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.82 Å
9LWF Cryo-EM structure of dual sensor bound GATOR2 complex Deposited 2025-02-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric（20） Consistent with protein count
Chain X 1–480（480 aa）
Chain Y 1–480（480 aa）
Mutation：Y375F Mutation：Y375F ZN ZINC ION × 32 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.41 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.