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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P58772 New Search
11PDB entries
21Biological assembly
65chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2D3E Crystal structure of the C-Terminal fragment of rabbit skeletal alpha-tropomyosin Deposited 2005-09-27 Assembly 1 Insufficient information Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 176–284（109 aa） Fragment：residues 151-175, residues 176-284
Chain B 176–284（109 aa） Fragment：residues 151-175, residues 176-284
Chain C 176–284（109 aa） Fragment：residues 151-175, residues 176-284
Chain D 176–284（109 aa） Fragment：residues 151-175, residues 176-284
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.2；293 K；MPD, AMMONIUM ACETATE, SODIUM CITRATE, pH 5.20, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.60 Å R-free 0.309
2EFR Crystal structure of the c-terminal tropomyosin fragment with N- and C-terminal extensions of the leucine zipper at 1.8 angstroms resolution Deposited 2007-02-23 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Chain B 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Mutation：C190S Mutation：C190S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；2.2M 1,6-HEXANEDIOL, 0.2M AMMONIUM ACETATE, 0.1M HEPES, PH7.5, pH 7.50, VAPOR DIFFUSION, SITTING DROP
Resolution 1.80 Å R-free 0.316
2EFR Crystal structure of the c-terminal tropomyosin fragment with N- and C-terminal extensions of the leucine zipper at 1.8 angstroms resolution Deposited 2007-02-23 Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Chain D 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Mutation：C190S Mutation：C190S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；2.2M 1,6-HEXANEDIOL, 0.2M AMMONIUM ACETATE, 0.1M HEPES, PH7.5, pH 7.50, VAPOR DIFFUSION, SITTING DROP
Resolution 1.80 Å R-free 0.316
2EFS Crystal structure of the C-terminal tropomyosin fragment with N- and C-terminal extensions of the leucine zipper at 2.0 angstroms resolution Deposited 2007-02-23 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Chain B 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Mutation：C190S Mutation：C190S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；40% MPD, 0.4M AMMONIUM ACETATE 0.1M TRIS-HCL, pH 8.50, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.00 Å R-free 0.304
2EFS Crystal structure of the C-terminal tropomyosin fragment with N- and C-terminal extensions of the leucine zipper at 2.0 angstroms resolution Deposited 2007-02-23 Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Chain D 176–273（98 aa） Fragment：residues 147-175, residues 176-301
Mutation：C190S Mutation：C190S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；40% MPD, 0.4M AMMONIUM ACETATE 0.1M TRIS-HCL, pH 8.50, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.00 Å R-free 0.304
2TMA TROPOMYOSIN CRYSTAL STRUCTURE AND MUSCLE REGULATION. APPENDIX. CONSTRUCTION OF AN ATOMIC MODEL FOR TROPOMYOSIN AND IMPLICATIONS FOR INTERACTIONS WITH ACTIN Deposited 1987-09-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–284（284 aa）
Chain B 1–284（284 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 15.00 Å
2W49 ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE Deposited 2008-11-24 Assembly 1 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric（36） Consistent with protein count
Chain A 8–284（277 aa） Fragment：RESIDUES 8-284
Chain B 8–284（277 aa） Fragment：RESIDUES 8-284
Chain C 8–284（277 aa） Fragment：RESIDUES 8-284
Chain T 8–284（277 aa） Fragment：RESIDUES 8-284
Chain U 8–284（277 aa） Fragment：RESIDUES 8-284
Chain V 8–284（277 aa） Fragment：RESIDUES 8-284
Chain W 8–284（277 aa） Fragment：RESIDUES 8-284
Chain X 8–284（277 aa） Fragment：RESIDUES 8-284
Not recorded CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer 20 MM MOPS BUFFER, 5 MM NAN3, AND MGCL2, ATP, CACL2, AND EGTA IN VARYING MILLIMOLAR CONCENTRATIONS；20 MM MOPS BUFFER, 5 MM NAN3, AND MGCL2, ATP, CACL2, AND EGTA IN VARYING MILLIMOLAR CONCENTRATIONS
cryo-EM vitrification conditions Cryogen HELIUM；SMASH AGAINST A LIQUID HELIUM COOLED GOLD COATED COPPER MIRROR
Resolution 35.00 Å
2W4U Isometrically contracting insect asynchronous flight muscle quick frozen after a length step Deposited 2008-12-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric（36） Consistent with protein count
Chain A 8–284（277 aa） Fragment：RESIDUES 8-284
Chain B 8–284（277 aa） Fragment：RESIDUES 8-284
Chain C 8–284（277 aa） Fragment：RESIDUES 8-284
Chain T 8–284（277 aa） Fragment：RESIDUES 8-284
Chain U 8–284（277 aa） Fragment：RESIDUES 8-284
Chain V 8–284（277 aa） Fragment：RESIDUES 8-284
Chain W 8–284（277 aa） Fragment：RESIDUES 8-284
Chain X 8–284（277 aa） Fragment：RESIDUES 8-284
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 MM MOPS BUFFER, 5 MM NAN3, AND MGCL2, ATP, CACL2, AND EGTA IN VARYING MILLIMOLAR CONCENTRATIONS；20 MM MOPS BUFFER, 5 MM NAN3, AND MGCL2, ATP, CACL2, AND EGTA IN VARYING MILLIMOLAR CONCENTRATIONS
cryo-EM vitrification conditions Cryogen HELIUM；SMASH AGAINST A LIQUID HELIUM COOLED GOLD COATED COPPER MIRROR
Resolution 35.00 Å
2Z5H Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT Deposited 2007-07-12 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain B 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain I 1–24（24 aa） Fragment：N terminal domain of Tropomyosin alpha-1 chain and C terminal domain of GCN4
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.89 Å R-free 0.247
2Z5H Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT Deposited 2007-07-12 Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain D 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.89 Å R-free 0.247
2Z5H Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT Deposited 2007-07-12 Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain F 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.89 Å R-free 0.247
2Z5H Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT Deposited 2007-07-12 Assembly 4 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain H 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.89 Å R-free 0.247
2Z5I Crystal structure of the head-to-tail junction of tropomyosin Deposited 2007-07-12 Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain B 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.246
2Z5I Crystal structure of the head-to-tail junction of tropomyosin Deposited 2007-07-12 Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain D 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.246
2Z5I Crystal structure of the head-to-tail junction of tropomyosin Deposited 2007-07-12 Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain F 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.246
2Z5I Crystal structure of the head-to-tail junction of tropomyosin Deposited 2007-07-12 Assembly 4 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain H 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.246
2Z5I Crystal structure of the head-to-tail junction of tropomyosin Deposited 2007-07-12 Assembly 5 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain I 1–24（24 aa） Fragment：N terminal domain of Tropomyosin alpha-1 chain and C terminal domain of GCN4
Chain J 1–24（24 aa） Fragment：N terminal domain of Tropomyosin alpha-1 chain and C terminal domain of GCN4
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.246
2Z5I Crystal structure of the head-to-tail junction of tropomyosin Deposited 2007-07-12 Assembly 6 Insufficient information Homooligomer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain A 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain B 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain C 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain D 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain E 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain F 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain G 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain H 254–284（31 aa） Fragment：C terminal domain of GCN4 and Tropomyosin alpha-1 chain
Chain I 1–24（24 aa） Fragment：N terminal domain of Tropomyosin alpha-1 chain and C terminal domain of GCN4
Chain J 1–24（24 aa） Fragment：N terminal domain of Tropomyosin alpha-1 chain and C terminal domain of GCN4
Not recorded MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.246
4A7F Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 3) Deposited 2011-11-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain B 98–233（136 aa） Fragment：RESIDUES 98-233
Chain H 98–233（136 aa） Fragment：RESIDUES 98-233
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 5 CA CALCIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer 5 MM HEPES-OH, 100 MM KCL, 2 MM MGCL2, 50 MM GLUTAMINE, 50 MM ARGININE；pH 7.2；5 MM HEPES-OH, 100 MM KCL, 2 MM MGCL2, 50 MM GLUTAMINE, 50 MM ARGININE
cryo-EM vitrification conditions Cryogen ETHANE；LIQUID ETHANE
Resolution 7.70 Å
4A7H Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 2) Deposited 2011-11-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain B 98–233（136 aa） Fragment：RESIDUES 98-233
Chain H 98–233（136 aa） Fragment：RESIDUES 98-233
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 5 CA CALCIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer 5MM TRIS, 100MM KCL, 2MM MGCL2, 50MM GLUTAMINE, 50MM ARGININ；pH 7.2；5MM TRIS, 100MM KCL, 2MM MGCL2, 50MM GLUTAMINE, 50MM ARGININ
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 90, TEMPERATURE- 101, INSTRUMENT- GATAN CRYOPLUNGE 3, METHOD- MANUAL BLOTTING FOR APPROXIMATELY 15 SECONDS,
Resolution 7.80 Å
4A7L Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 1) Deposited 2011-11-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain B 98–233（136 aa） Fragment：RESIDUES 98-233
Chain H 98–233（136 aa） Fragment：RESIDUES 98-233
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 5 CA CALCIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM buffer 5MM TRIS, 100MM KCL, 2MM MGCL2, 50MM GLUTAMINE, 50MM ARGININ；pH 7.2；5MM TRIS, 100MM KCL, 2MM MGCL2, 50MM GLUTAMINE, 50MM ARGININ
cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 90, TEMPERATURE- 101, INSTRUMENT- GATAN CRYOPLUNGE 3, METHOD- MANUAL BLOTTING FOR APPROXIMATELY 15 SECONDS,
Resolution 8.10 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.