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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P60484 New Search
11PDB entries
21Biological assembly
26chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1D5R Crystal Structure of the PTEN Tumor Suppressor Deposited 1999-10-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 7–285（279 aa） Fragment：RESIDUES 7-353
Chain A 310–353（44 aa） Fragment：RESIDUES 7-353
Mutation：RESIDUES 286-309 ARE REPLACED BY VAL Mutation：RESIDUES 286-309 ARE REPLACED BY VAL TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；NA/K TARTRATE, 5% GLYCEROL, 100MM TRIS-CL, 10MM DTT, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.10 Å R-free 0.276
2KYL Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN Deposited 2010-06-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 391–403（13 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.5；298 K；Ionic strength (raw mmCIF value) 0.2；Pressure ambient
NMR sample composition 0.6mM [U-100% 13C; U-100% 15N] PDZ-domain-1, 1.2mM PTEN-2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
4O1V SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer Deposited 2013-12-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 354–368（15 aa） Fragment：UNP residues 354-368
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；100 mM Tris, 100 mM sodium malonate, 36% PEG400, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.221
5BUG Crystal structure of human phosphatase PTEN oxidized by H2O2 Deposited 2015-06-03 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count
Chain A 14–351（338 aa） Fragment：PTEN wt 14-351 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.40 Å R-free 0.211
5BUG Crystal structure of human phosphatase PTEN oxidized by H2O2 Deposited 2015-06-03 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count
Chain B 14–351（338 aa） Fragment：PTEN wt 14-351 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.40 Å R-free 0.211
5BUG Crystal structure of human phosphatase PTEN oxidized by H2O2 Deposited 2015-06-03 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count
Chain C 14–351（338 aa） Fragment：PTEN wt 14-351 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.40 Å R-free 0.211
5BUG Crystal structure of human phosphatase PTEN oxidized by H2O2 Deposited 2015-06-03 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count
Chain D 14–351（338 aa） Fragment：PTEN wt 14-351 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.40 Å R-free 0.211
5BZX Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex Deposited 2015-06-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 VO4 VANADATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.50 Å R-free 0.204
5BZX Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex Deposited 2015-06-11 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.50 Å R-free 0.204
5BZX Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex Deposited 2015-06-11 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 VO4 VANADATE ION × 1 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.50 Å R-free 0.204
5BZX Crystal structure of human phosphatase PTEN treated with a bisperoxovanadium complex Deposited 2015-06-11 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrat, 7.5% glycerol
Resolution 2.50 Å R-free 0.204
5BZZ Crystal structure of human phosphatase PTEN in its reduced state Deposited 2015-06-11 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrate, 7.5% glycerol
Resolution 2.20 Å R-free 0.221
5BZZ Crystal structure of human phosphatase PTEN in its reduced state Deposited 2015-06-11 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrate, 7.5% glycerol
Resolution 2.20 Å R-free 0.221
5BZZ Crystal structure of human phosphatase PTEN in its reduced state Deposited 2015-06-11 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain C 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrate, 7.5% glycerol
Resolution 2.20 Å R-free 0.221
5BZZ Crystal structure of human phosphatase PTEN in its reduced state Deposited 2015-06-11 Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain D 14–351（338 aa） Fragment：PTEN wt 7-353 delta 286-309
Mutation：Deletion 286-309 TLA L(+)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M MES pH 6.5, 1.25 M L-tartrate, 7.5% glycerol
Resolution 2.20 Å R-free 0.221
7JUK Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG) Deposited 2020-08-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 7–285（279 aa）
Chain A 310–353（44 aa）
Chain A 378–390（13 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；1.2 M DL-malic acid
Resolution 3.15 Å R-free 0.289
7JUL Crystal structure of non phosphorylated PTEN (n-crPTEN-13sp-T1, SDTTDSDPENEG) Deposited 2020-08-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 7–285（279 aa）
Chain A 310–353（44 aa）
Chain A 378–390（13 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293.15 K；1:1 volume of well solution: 100 mM Bis-Tris propane pH 7.0, 1.2 M DL-malic acid
Resolution 2.53 Å R-free 0.234
7JVX Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to peptide pSDpTpTDpSDPENEPFDED) Deposited 2020-08-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–403（403 aa）
Not recorded PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；300 mM citrate
Resolution 3.20 Å R-free 0.296
7PC7 The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN Deposited 2021-08-03 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 394–403（10 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 6 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Tris 8.5, 22 % v/v PEG Smear Broad
Resolution 2.10 Å R-free 0.218
7PC7 The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN Deposited 2021-08-03 Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 394–403（10 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 6 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M Tris 8.5, 22 % v/v PEG Smear Broad
Resolution 2.10 Å R-free 0.218
8X3S Crystal structure of human WDR5 in complex with PTEN Deposited 2023-11-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 115–148（34 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；0.2 M lithium sulfate monohydrate, 0.1 M HEPES at pH 7.5, 25% w/v polyethylene glycol 3350
Resolution 1.87 Å R-free 0.259

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.