Current Protein Identity：P63098
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1AUI HUMAN CALCINEURIN HETERODIMER Deposited 1997-08-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–169（169 aa）
|
Not recorded | ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；PROTEIN WAS CRYSTALLIZED FROM 8% PEG 6000, 0.1M CACL2, 0.1M TES PH 7.5, 1 MM DTT.
|
Resolution 2.10 Å |
| 1M63 Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes Deposited 2002-07-12 | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain B
1–169（169 aa）
Chain F
1–169（169 aa）
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 2 CA CALCIUM ION × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.5；0.1 M NA CACODYLATE, 0.2 M MGCL2, 13% PEG8000, 2.5% ETHANOL, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 295K
|
Resolution 2.80 Å R-free 0.322 |
| 1MF8 Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin Deposited 2002-08-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
0–169（170 aa）
|
Not recorded | PO4 PHOSPHATE ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.6；12% PEG 4000, 5MM POTASSIUM PHOSPHATE, 75MM SODIUM CITRATE, 15% GLYCEROL, 5MM TRIS, PH 4.6, MICROBATCH, TEMPERATURE 292K
|
Resolution 3.10 Å R-free 0.300 |
| 2P6B Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide Deposited 2007-03-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
16–170（155 aa）
Fragment：Residues 16-170
Chain D
16–170（155 aa）
Fragment：Residues 16-170
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 2 PO4 PHOSPHATE ION × 2 CA CALCIUM ION × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；12% PEG 4000, 0.1M calcium chloride, 0.1M TES, 0.001M DTT, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.30 Å R-free 0.254 |
| 3LL8 Crystal Structure of Calcineurin in Complex with AKAP79 Peptide Deposited 2010-01-28 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
16–170（155 aa）
Fragment：UNP residues 16-170
|
Not recorded | PO4 PHOSPHATE ION × 1 ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；PEG 20,000
MgSO4
CaCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å R-free 0.228 |
| 3LL8 Crystal Structure of Calcineurin in Complex with AKAP79 Peptide Deposited 2010-01-28 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
16–170（155 aa）
Fragment：UNP residues 16-170
|
Not recorded | PO4 PHOSPHATE ION × 1 ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；PEG 20,000
MgSO4
CaCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å R-free 0.228 |
| 3LL8 Crystal Structure of Calcineurin in Complex with AKAP79 Peptide Deposited 2010-01-28 | Assembly 3 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
16–170（155 aa）
Fragment：UNP residues 16-170
Chain D
16–170（155 aa）
Fragment：UNP residues 16-170
|
Not recorded | PO4 PHOSPHATE ION × 2 ZN ZINC ION × 2 FE FE (III) ION × 2 CA CALCIUM ION × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；PEG 20,000
MgSO4
CaCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å R-free 0.228 |
| 4F0Z Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L Deposited 2012-05-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
1–170（170 aa）
Fragment：Calcineurin B Subunit
|
Not recorded | GOL GLYCEROL × 8 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；295 K；0.16 M ammonium citrate dibasic, 20% (w/v) PEG3350, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.70 Å R-free 0.178 |
| 4OR9 Crystal structure of human calcineurin Deposited 2014-02-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–170（170 aa）
Fragment：regulatory subunit
|
Not recorded | FE FE (III) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；294 K；100mM MES, pH 5.8, 7% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.23 Å R-free 0.215 |
| 4ORA Crystal structure of a human calcineurin mutant Deposited 2014-02-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–170（170 aa）
|
Not recorded | ZN ZINC ION × 1 FE FE (III) ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；294 K；100 mM MES, pH 5.8, 9% PEG 3350, 4% Glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.75 Å R-free 0.249 |
| 4ORC Crystal structure of mammalian calcineurin Deposited 2014-02-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–170（170 aa）
Fragment：regulatory subunit
|
Not recorded | ZN ZINC ION × 1 FE FE (III) ION × 1 PO4 PHOSPHATE ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；294 K；100mM MES, pH 6.1, 10% PEG3350, 0.2M CaCl2, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.70 Å R-free 0.260 |
| 5SVE Structure of Calcineurin in complex with NFATc1 LxVP peptide Deposited 2016-08-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
1–170（170 aa）
|
Not recorded | FE FE (III) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；0.1 M HEPES pH 7.0
15% Peg 4000
|
Resolution 2.60 Å R-free 0.239 |
| 6NUC Structure of Calcineurin in complex with NHE1 peptide Deposited 2019-01-31 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
16–170（155 aa）
|
Not recorded | FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.5；298 K；40% (v/v) PEG 600, 100 mM CHES/ Sodium hydroxide pH 9.5, 0.2 M MgCl2
|
Resolution 1.90 Å R-free 0.194 |
| 6NUF Structure of Calcineurin in complex with NHE1 peptide Deposited 2019-01-31 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
16–170（155 aa）
|
Not recorded | FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 PGE TRIETHYLENE GLYCOL × 2 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；40% (v/v) PEG 600, 100 mM CHES/ Sodium hydroxide pH 9.5, 0.2 M MgCl2
|
Resolution 1.90 Å R-free 0.209 |
| 6NUU Structure of Calcineurin mutant in complex with NHE1 peptide Deposited 2019-02-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
16–170（155 aa）
|
Not recorded | FE FE (III) ION × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9.5；298 K；40% (v/v) PEG 600, 100 mM CHES/ Sodium hydroxide pH 9.5, 0.2 M MgCl2
|
Resolution 2.30 Å R-free 0.243 |
| 7U0T Crystal Structure of a human Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-520 Deposited 2022-02-18 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
3–170（168 aa）
|
Not recorded | CA CALCIUM ION × 4 EDO 1,2-ETHANEDIOL × 1 KXX (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,22R,26aS)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；287 K；Microlytics MCSG-1 C5: 0.2M Magnesium Acetate, 20% PEG 3,350, HosaA.18272.a.TM11.PD38439 at 20mg/ml + FK-520 (Purified from SEC): cryo: 20% ethylene glycol: tray 318701c5, puck oxo8-2
|
Resolution 2.45 Å R-free 0.260 |
| 9B9G Structure of the PI4KA complex bound to Calcineurin Deposited 2024-04-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count |
Chain H
1–170（170 aa）
Chain J
1–170（170 aa）
|
Not recorded | CA CALCIUM ION × 8 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7；Freshly prepared gel filtration buffer, filtered through 0.22um filter and degassed
cryo-EM vitrification conditions
Cryogen ETHANE；Blot force -5, blot time 1 s
|
Resolution 3.50 Å |
| 9CHU Cryo-EM structure of calcineurin fused beta2 adrenergic receptor in norepinephrine bound inactive state Deposited 2024-07-02 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
16–170（155 aa）
|
Not recorded | E5E Noradrenaline × 1 FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.49 Å |
| 9CHV cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in apo state Deposited 2024-07-02 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
16–170（155 aa）
|
Not recorded | FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.95 Å |
| 9CHX cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state Deposited 2024-07-02 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
16–170（155 aa）
|
Not recorded | CAU (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol × 1 FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9NXE Crystal Structure of Calcineurin Clinical Variant E282K Deposited 2025-03-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
16–170（155 aa）
|
Not recorded | PEG DI(HYDROXYETHYL)ETHER × 1 FE FE (III) ION × 1 ZN ZINC ION × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；290 K；0.1 M CAPS pH 9, 0.2 M MgCl2 and 24% PEG 600
|
Resolution 2.09 Å R-free 0.243 |
| 9NXF Crystal structure of CN:Tak1 complex Deposited 2025-03-25 | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
16–170（155 aa）
|
Not recorded | FE FE (III) ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；200 mM Sodium citrate tribasic pH 8.4, 22% PEG 3350, 3% ethanol. Microseeding
|
Resolution 3.13 Å R-free 0.295 |
| 9NXF Crystal structure of CN:Tak1 complex Deposited 2025-03-25 | Assembly 2 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain E
16–170（155 aa）
|
Not recorded | FE FE (III) ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CA CALCIUM ION × 4 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；200 mM Sodium citrate tribasic pH 8.4, 22% PEG 3350, 3% ethanol. Microseeding
|
Resolution 3.13 Å R-free 0.295 |
| 9NXN Crystal structure of CN:RII alpha Deposited 2025-03-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
1–170（170 aa）
|
Not recorded | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；289 K；0.1 M sodium citrate pH 5.0, 0.1 M Magnesium chloride hexahydrate, 15% PEG 4000
|
Resolution 2.10 Å R-free 0.250 |