Current Protein Identity：P9WNW5
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 9Y4S Crystal structure of DNA integrity scanning protein (DisA) from Mycobacterium tuberculosis in complex with cyclic di-AMP Deposited 2025-09-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
5–356（352 aa）
Fragment：T5-S356
Chain B
5–356（352 aa）
Fragment：T5-S356
Chain C
5–356（352 aa）
Fragment：T5-S356
Chain D
5–356（352 aa）
Fragment：T5-S356
Chain E
5–356（352 aa）
Fragment：T5-S356
Chain F
5–356（352 aa）
Fragment：T5-S356
Chain G
5–356（352 aa）
Fragment：T5-S356
Chain H
5–356（352 aa）
Fragment：T5-S356
|
Not recorded | CL CHLORIDE ION × 14 PGE TRIETHYLENE GLYCOL × 1 PG4 TETRAETHYLENE GLYCOL × 1 2BA (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；Morpheus Fusion F12: 12.5%(v/v) MPD, 12.5%(v/v) PEG 1000, 12.5%(w/v) PEG 3350, 100 mM Tris/BICINE, pH 8.5, 20 mM D-Glucose, 20 mM D-Mannose, 20 mM D-Galactose, 20 mM L-Fucose, 20 mM D-Xylose and 20 mM N-Acetyl-D-Glucosamine. MytuD.17706.a.B2.PW39404 at 13.1 mg/mL. Screened as apo protein but cyclic di-AMP was bound to 4 sites likely acquired from the expression host. plate 19976 F12 drop 2, Puck: PSL-2416, Cryo: direct
|
Resolution 2.89 Å R-free 0.252 |
| 9Y9Y Crystal structure of DNA integrity scanning protein DisA from Mycobacterium tuberculosis in complex with cyclic di-AMP and bromide Deposited 2025-09-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
5–356（352 aa）
Fragment：T5-S356
Chain B
5–356（352 aa）
Fragment：T5-S356
Chain C
5–356（352 aa）
Fragment：T5-S356
Chain D
5–356（352 aa）
Fragment：T5-S356
Chain E
5–356（352 aa）
Fragment：T5-S356
Chain F
5–356（352 aa）
Fragment：T5-S356
Chain G
5–356（352 aa）
Fragment：T5-S356
Chain H
5–356（352 aa）
Fragment：T5-S356
|
Not recorded | 2BA (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide × 4 BR BROMIDE ION × 8 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；Morpheus B12: 12.5%(v/v) MPD, 12.5%(v/v) PEG 1000, 12.5%(w/v) PEG 3350, 100 mM Tris/BICINE, pH 8.5, 30 mM NaF, 30 mM NaBr and 30 mM NaI. MytuD.17706.a.B2.PW39404 at 13.1 mg/mL. Screened as apo protein but cyclic di-AMP was bound to 4 sites likely acquired from the expression host. Larged ion modeled as a bromide was near each ligand. plate 19967 C12 drop 3, Puck: PSL-1611, Cryo: direct
|
Resolution 3.03 Å R-free 0.268 |