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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q01454 New Search
20PDB entries
20Biological assembly
60chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4C8H Crystal structure of the C-terminal region of yeast Ctf4, selenomethionine protein. Deposited 2013-10-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 471–927（457 aa） Fragment：C-TERMINAL DOMAIN
Chain B 471–927（457 aa） Fragment：C-TERMINAL DOMAIN
Chain C 471–927（457 aa） Fragment：C-TERMINAL DOMAIN
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions 0.2 M TRI-SODIUM CITRATE PH 6.2, 7-9% PEG 8000
Resolution 2.69 Å R-free 0.225
4C8S Crystal structure of the C-terminal region of yeast Ctf4 Deposited 2013-10-01 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Chain B 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Chain C 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions 0.2 M TRI-SODIUM CITRATE PH 6.2, 7-9% PEG 8000
Resolution 3.00 Å R-free 0.205
4C93 Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Pol alpha. Deposited 2013-10-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Chain B 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Chain C 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions 0.2 M TRI-SODIUM CITRATE PH 6.2, 7-9% PEG 8000
Resolution 2.69 Å R-free 0.210
4C95 Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Sld5 Deposited 2013-10-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Chain B 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Chain C 471–927（457 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 471-927
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions 0.2 M TRI-SODIUM CITRATE PH 6.2, 7-9% PEG 8000
Resolution 2.69 Å R-free 0.214
5HOG Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Dna2. Deposited 2016-01-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 450–927（478 aa） Fragment：UNP residues 450-927
Chain B 450–927（478 aa） Fragment：UNP residues 450-927
Chain C 450–927（478 aa） Fragment：UNP residues 450-927
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；0.2 M tri-sodium citrate pH 6.2, 7-9% PEG 8000 and 0.45-0.9 M NaCl.
Resolution 3.09 Å R-free 0.226
5HOI Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Tof2. Deposited 2016-01-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 472–927（456 aa） Fragment：UNP residues 472-927
Chain B 472–927（456 aa） Fragment：UNP residues 472-927
Chain C 472–927（456 aa） Fragment：UNP residues 472-927
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；0.2 M tri-sodium citrate pH 6.2, 7-9% PEG 8000 and 0.45-0.9 M NaCl
Resolution 3.30 Å R-free 0.224
5NXQ Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to a stapled Sld5 CIP Deposited 2017-05-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 471–927（457 aa） Fragment：UNP residues 471-927
Chain B 471–927（457 aa） Fragment：UNP residues 471-927
Chain C 471–927（457 aa） Fragment：UNP residues 471-927
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；0.2 M tri-sodium citrate pH 6.2 7.5-9% (w/v) PEG 8000 0.40-0.65 M NaCI
Resolution 2.41 Å R-free 0.211
6PTJ Structure of Ctf4 trimer in complex with one CMG helicase Deposited 2019-07-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain E 1–927（927 aa）
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6PTN Structure of Ctf4 trimer in complex with two CMG helicases Deposited 2019-07-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 25 PDB declaration: 25-meric（25） Consistent with protein count
Chain E 1–927（927 aa）
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.80 Å
6PTO Structure of Ctf4 trimer in complex with three CMG helicases Deposited 2019-07-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 36 PDB declaration: 36-meric（36） Consistent with protein count
Chain X 1–927（927 aa）
Chain Y 1–927（927 aa）
Chain Z 1–927（927 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.00 Å
6SKL Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1 Deposited 2019-08-16 Assembly 1 Protein–DNA Heteromer；Protein × 16 PDB declaration: octadecameric（18） Consistent with all polymers
Chain F 1–927（927 aa） Fragment：Mcm6
Chain G 1–927（927 aa） Fragment：Mcm6
Chain H 1–927（927 aa） Fragment：Mcm6
Not recorded ZN ZINC ION × 5 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MG MAGNESIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Three microlitres of sample was applied on a grid and incubated for 15-30 s at 4 degC before manually blotting with filter paper for 10 s and plunge-freezing in liquid ethane.
Resolution 3.70 Å
7PMN S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) Deposited 2021-09-02 Assembly 1 Protein–DNA Heteromer；Protein × 20 PDB declaration: 22-meric（22） Consistent with all polymers
Chain F 1–927（927 aa） Fragment：Mcm6
Chain G 1–927（927 aa） Fragment：Mcm6
Chain H 1–927（927 aa） Fragment：Mcm6
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 MG MAGNESIUM ION × 2 ZN ZINC ION × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE；Manual plunger
Resolution 3.20 Å
8B9A S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Deposited 2022-10-05 Assembly 1 Protein–DNA Heteromer；Protein × 21 PDB declaration: 23-meric（23） Consistent with all polymers
Chain H 1–927（927 aa）
Chain K 1–927（927 aa）
Chain L 1–927（927 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 4 MG MAGNESIUM ION × 4 ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8B9B S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA substrate containing a 60 nucleotide lagging strand. Deposited 2022-10-05 Assembly 1 Protein–DNA Heteromer；Protein × 21 PDB declaration: 23-meric（23） Consistent with all polymers
Chain H 1–927（927 aa）
Chain K 1–927（927 aa）
Chain L 1–927（927 aa）
Not recorded ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 4 MG MAGNESIUM ION × 4 ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8KG6 Yeast replisome in state I Deposited 2023-08-17 Assembly 1 Protein–DNA Heteromer；Protein × 18 PDB declaration: 20-meric（20） Consistent with all polymers
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Chain H 1–927（927 aa）
Not recorded ZN ZINC ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 MG MAGNESIUM ION × 5 AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE；blot with filter paper for 3-4 seconds before plunging.
Resolution 3.07 Å
8KG8 Yeast replisome in state II Deposited 2023-08-17 Assembly 1 Protein–DNA Heteromer；Protein × 16 PDB declaration: octadecameric（18） Consistent with all polymers
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Chain H 1–927（927 aa）
Not recorded ZN ZINC ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 MG MAGNESIUM ION × 5 AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE；blot with filter paper for 3-4 seconds before plunging.
Resolution 4.23 Å
8KG9 Yeast replisome in state III Deposited 2023-08-17 Assembly 1 Protein–DNA Heteromer；Protein × 16 PDB declaration: octadecameric（18） Consistent with all polymers
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Chain H 1–927（927 aa）
Not recorded ZN ZINC ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 2 MG MAGNESIUM ION × 4 AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE；blot with filter paper for 3-4 seconds before plunging.
Resolution 4.52 Å
8W7M Yeast replisome in state V Deposited 2023-08-30 Assembly 1 Protein–DNA Heteromer；Protein × 15 PDB declaration: hexadecameric（16） Consistent with all polymers
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Chain H 1–927（927 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 MG MAGNESIUM ION × 4 ZN ZINC ION × 5 AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE；blot with filter paper for 3-4 seconds before plunging.
Resolution 4.12 Å
8W7S Yeast replisome in state IV Deposited 2023-08-31 Assembly 1 Protein–DNA Heteromer；Protein × 15 PDB declaration: hexadecameric（16） Consistent with all polymers
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Chain H 1–927（927 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE；blot with filter paper for 3-4 seconds before plunging.
Resolution 7.39 Å
8XGC Structure of yeast replisome associated with FACT and histone hexamer, Composite map Deposited 2023-12-15 Assembly 1 Protein–DNA Heteromer；Protein × 27 PDB declaration: 29-meric（29） Consistent with all polymers
Chain F 1–927（927 aa）
Chain G 1–927（927 aa）
Chain H 1–927（927 aa）
Not recorded ZN ZINC ION × 7 ADP ADENOSINE-5'-DIPHOSPHATE × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.