8xgc

Structure of yeast replisome associated with FACT and histone hexamer, Composite map

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM2

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q1S9_YEASX
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 2； PDBConstruct 1–868； UniProt 1–868

DNA replication licensing factor MCM3

OrganismNot specified

UniProt P24279

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM3_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 3； PDBConstruct 1–971； UniProt 1–971

DNA replication licensing factor MCM4

OrganismNot specified

UniProt P30665

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM4_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 4； PDBConstruct 1–933； UniProt 1–933

Minichromosome maintenance protein 5

OrganismNot specified

UniProt P29496

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM5_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 5； PDBConstruct 1–775； UniProt 1–775

DNA replication licensing factor MCM6

OrganismNot specified

UniProt P53091

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM6_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 6； PDBConstruct 1–1017； UniProt 1–1017

DNA replication licensing factor MCM7

OrganismNot specified

UniProt A0A8H4BTB2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A8H4BTB2_YEASX
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 7； PDBConstruct 1–845； UniProt 1–845

DNA polymerase epsilon catalytic subunit A

OrganismNot specified

UniProt P21951

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DPOE_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain 8； PDBConstruct 1–2222； UniProt 1–2222

DNA polymerase epsilon subunit B

OrganismNot specified

UniProt P24482

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DPB2_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain 9； PDBConstruct 1–689； UniProt 1–689

DNA replication complex GINS protein PSF1

OrganismNot specified

UniProt Q12488

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSF1_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain A； PDBConstruct 1–208； UniProt 1–208

DNA replication complex GINS protein PSF3

OrganismNot specified

UniProt Q12146

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSF3_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain C； PDBConstruct 1–194； UniProt 1–194

DNA replication complex GINS protein SLD5

OrganismNot specified

UniProt Q03406

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SLD5_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain D； PDBConstruct 1–294； UniProt 1–294

Cell division control protein 45

OrganismNot specified

UniProt Q08032

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC45_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain E； PDBConstruct 1–650； UniProt 1–650

DNA polymerase alpha-binding protein

OrganismNot specified

UniProt Q01454

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CTF4_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain F； PDBConstruct 1–927； UniProt 1–927 Author chain G； PDBConstruct 1–927； UniProt 1–927 Author chain H； PDBConstruct 1–927； UniProt 1–927

Topoisomerase 1-associated factor 1

OrganismNot specified

UniProt P53840

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TOF1_YEAST
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain I； PDBConstruct 1–1238； UniProt 1–1238

Chromosome segregation in meiosis protein 3

OrganismNot specified

UniProt Q04659

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CSM3_YEAST
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain J； PDBConstruct 1–317； UniProt 1–317

Mediator of replication checkpoint protein 1

OrganismNot specified

UniProt P25588

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MRC1_YEAST
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain K； PDBConstruct 1–1096； UniProt 1–1096

FACT complex subunit SPT16

OrganismNot specified

UniProt P32558

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SPT16_YEAST
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain L； PDBConstruct 1–1035； UniProt 1–1035

FACT complex subunit POB3

OrganismNot specified

UniProt Q04636

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	POB3_YEAST
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain M； PDBConstruct 1–552； UniProt 1–552

Histone H3

OrganismNot specified

UniProt A0A6A5Q536

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q536_YEASX
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain N； PDBConstruct 1–136； UniProt 1–136 Author chain R； PDBConstruct 1–136； UniProt 1–136

Histone H4

OrganismNot specified

UniProt P02309

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H2A.1 × 1 （P04911） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H4_YEAST
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain O； PDBConstruct 1–103； UniProt 1–103 Author chain S； PDBConstruct 1–103； UniProt 1–103

Histone H2A.1

OrganismNot specified

UniProt P04911

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2B.2 × 1 （P02294） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H2A1_YEAST
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain P； PDBConstruct 1–132； UniProt 1–132

Histone H2B.2

OrganismNot specified

UniProt P02294

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 27 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） Minichromosome maintenance protein 5 × 1 （P29496） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A8H4BTB2） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） DNA replication complex GINS protein PSF1 × 1 （Q12488） DNA replication complex GINS protein PSF2 × 1 DNA replication complex GINS protein PSF3 × 1 （Q12146） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （Q01454） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） Mediator of replication checkpoint protein 1 × 1 （P25588） FACT complex subunit SPT16 × 1 （P32558） FACT complex subunit POB3 × 1 （Q04636） Histone H3 × 2 （A0A6A5Q536） Histone H4 × 2 （P02309） Histone H2A.1 × 1 （P04911） DNA (51-MER) × 1 DNA (39-MER) × 1 ZINC ION × 7 ADENOSINE-5'-DIPHOSPHATE × 5	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H2B2_YEAST
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain Q； PDBConstruct 1–131； UniProt 1–131

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8xgc
Deposition date deposition_date	2023-12-15
Structure title title	Structure of yeast replisome associated with FACT and histone hexamer, Composite map
Keywords keywords	Replisome, FACT, histone hexamer, REPLICATION; REPLICATION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8xgc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8xgc__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8xgc__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	82.37 Å
Rg (electron density)	81.88 Å
Total Rg	81.59 Å
Atom count	82765
Residues	10409
Excluded volume	1469600 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8xgc__assembly_1__model_1`	29-meric （29）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (27)

Entity 1 Entity 1 polymer

Description description	DNA replication licensing factor MCM2
Molecular weight formula_weight	98911.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2
Atom count atom_count	82765

MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPDIDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERDRLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREELTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIYTLGH

Entity 2 Entity 2 polymer

Description description	DNA replication licensing factor MCM3
Molecular weight formula_weight	107653.5 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV

Entity 3 Entity 3 polymer

Description description	DNA replication licensing factor MCM4
Molecular weight formula_weight	105138.4 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEGNIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSSSSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDPKTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVESSDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Entity 4 Entity 4 polymer

Description description	Minichromosome maintenance protein 5
Molecular weight formula_weight	86505.7 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKRRLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Entity 5 Entity 5 polymer

Description description	DNA replication licensing factor MCM6
Molecular weight formula_weight	113110.2 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6

MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGPFVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGNGTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKKKTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRLAFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Entity 6 Entity 6 polymer

Description description	DNA replication licensing factor MCM7
Molecular weight formula_weight	95049.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7

MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLSNCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDIDLQDA

Entity 7 Entity 7 polymer

Description description	DNA polymerase epsilon catalytic subunit A
Molecular weight formula_weight	255992.5 kDa
EC 编号 ec_number	2.7.7.7,3.1.11.-
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	8

MMFGKKKNNGGSSTARYSAGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIATKEDKFKQTSLTKFFSKTKNVPTMGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKRKRNQLTNEEDPLVLPSEIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNTNSSRERSALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQRAIMDLGASVTFRSKAMGALGKGIQQGFEMKDLSMAENERYLSGFSMDIGYLLHFPTSIGYEFFSLFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETYSYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSLNEVLLPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSDLVNNNMGIDDKDAVINSPSEFVHDAFSNDALNVLRGMLKEWWDEALKENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNSGTQRPTQIVNVKKQDKEDSVENSLNGFSHLFSKPLMKRVKKLFKNQQEFILDPQYEADYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKSTILEIRTLRKELLKIFELREFAKVAEFKDPSLSLVVPDFLCEYCFFISDIDFCKAAPESIFSCVRCHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPRESIVQKLNVFKQVAKYYGFDILLSCIADLTI

Entity 8 Entity 8 polymer

Description description	DNA polymerase epsilon subunit B
Molecular weight formula_weight	78425.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	9

MFGSGNVLPVKIQPPLLRPLAYRVLSRKYGLSIKSDGLSALAEFVGTNIGANWRQGPATIKFLEQFAAVWKQQERGLFIDQSGVKEVIQEMKEREKVEWSHEHPIQHEENILGRTDDDENNSDDEMPIAADSSLQNVSLSSPMRQPTERDEYKQPFKPESSKALDWRDYFKVINASQQQRFSYNPHKMQFIFVPNKKQNGLGGIAGFLPDIEDKVQMFLTRYYLTNDRVMRNENFQNSDMFNPLSSMVSLQNELSNTNRQQQSSSMSITPIKNLLGRDAQNFLLLGLLNKNFKGNWSLEDPSGSVEIDISQTIPTQGHYYVPGCMVLVEGIYYSVGNKFHVTSMTLPPGERREITLETIGNLDLLGIHGISNNNFIARLDKDLKIRLHLLEKELTDHKFVILGANLFLDDLKIMTALSKILQKLNDDPPTLLIWQGSFTSVPVFASMSSRNISSSTQFKNNFDALATLLSRFDNLTENTTMIFIPGPNDLWGSMVSLGASGTLPQDPIPSAFTKKINKVCKNVVWSSNPTRIAYLSQEIVIFRDDLSGRFKRHRLEFPFNESEDVYTENDNMMSKDTDIVPIDELVKEPDQLPQKVQETRKLVKTILDQGHLSPFLDSLRPISWDLDHTLTLCPIPSTMVLCDTTSAQFDLTYNGCKVINPGSFIHNRRARYMEYVPSSKKTIQEEIYI

Entity 9 Entity 9 polymer

Description description	DNA replication complex GINS protein PSF1
Molecular weight formula_weight	24230.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQLGMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDTNNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI

Entity 10 Entity 10 polymer

Description description	DNA replication complex GINS protein PSF2
Molecular weight formula_weight	29341.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKALNNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWLVLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINELRPFITEIMDKLREIHTASLTAGTENDEEEFNIENLYFQGSGGGGGGSRDYKDHDGDYKDHDIDYKDDDDK

Entity 11 Entity 11 polymer

Description description	DNA replication complex GINS protein PSF3
Molecular weight formula_weight	21977.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGDEALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKELANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKSHESYKDTKRWMFKK

Entity 12 Entity 12 polymer

Description description	DNA replication complex GINS protein SLD5
Molecular weight formula_weight	33983.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDFSDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPNESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKWNEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI

Entity 13 Entity 13 polymer

Description description	Cell division control protein 45
Molecular weight formula_weight	74324.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL

Entity 14 Entity 14 polymer

Description description	DNA polymerase alpha-binding protein
Molecular weight formula_weight	104543.4 kDa
Source method src_method	nat
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,G,H

MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK

Entity 15 Entity 15 polymer

Description description	Topoisomerase 1-associated factor 1
Molecular weight formula_weight	141296.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MSADLQQGTTNAADFSLTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKRWFKLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLAAKLAKNNPDHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQLVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFRNVIAIEPGEFTINTKKSMPKKGITSIDTLPPNVSMDDISLNTVISSFHKNKVFGFLLTLTSSLSKEFDQDFINIPLLEIMFYFTKDVNQELLFPRQFETGTHSKVVNKNESSSANNIVTSAGFELSKLLQKEHQMRKNVIKHTSARHSRFGGLLSIQTPDKTRLTVSGSQALVDEKIALQKLDDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESNGKHFKEFINNFIDSGFNILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFVKYQLLRSKIDNSADIKQVSEALKEVTFILVSSLLRSAYDLKNWTVTHAGMIAFNELLNLVSRTKAAQEEDSTDIEFIVSRLFSDERIQLLSNLPKIGSKYSLQFMKSCIELTHSVLKVLEQYSDDKTLVIEGKSRRQKKFNISEGDITKLIEEENVDRDEALDILTSSLRSIEVNFQKVQANYMTEPVIETYINFLERFRELEDDSIKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRKYVSQFSDYFLARLKKRLKKSPAWFVGLLFPPLHNSEVGFYQRYGEYNVLNNESMYAAPASQFKPIPDEEALPPSILLDMKYGVLVSTLLDDGKTELLDQLLKHITHTLDIFKSWLTVNVNAGKETVNPPNEYFTLTGVLNNDPIFKDKDYRALLLLIGYSIPRKINEPCFLPGTVEVSDLTVSCELVKKYLSTPFETPNGLPSSSYLLRVRSEKDSFSHNEQDGWEGDDDYDYNDPYIVPDDQILSKSDAAYFKDLDNNASDKLKGTKFSKGIARSKKKDKRKRRKGEAKTNLPMFGDQDDERPQTVRERHGVFSKEFISDSEDDEDLMNPIFFENETYMRWLLDKNNGQLTEDRYIQFAKFAAERMNNGGVVTGDYTSLFGGSIPSIESIRATESSSFAPDKSLISLASHVASEMSIFDVNNNNNNQLSDDDVNSESRNSLGSSQPSNSQNMFQSEVYSRKESTKRSLEASAADESDEDEEAIRLFGKKSRVVLSQGDSDD

Entity 16 Entity 16 polymer

Description description	Chromosome segregation in meiosis protein 3
Molecular weight formula_weight	36402.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MDQDFDSLLLGFNDSDSVQKDPTVPNGLDGSVVDPTIADPTAITARKRRPQVKLTAEKLLSDKGLPYVLKNAHKRIRISSKKNSYDNLSNIIQFYQLWAHELFPKAKFKDFMKICQTVGKTDPVLREYRVSLFRDEMGMSFDVGTRETGQDLERQSPMVEEHVTSAEERPIVADSFAQDKRNVNNVDYDNDEDDDIYHLSYRNRRGRVLDERGNNETVLNNVVPPKEDLDALLKTFRVQGPVGLEENEKKLLLGWLDAHRKMEKGSMTEEDVQLIQSLEEWEMNDIEGQHTHYDLLPGGDEFGVDQDELDAMKEMGF

Entity 17 Entity 17 polymer

Description description	Mediator of replication checkpoint protein 1
Molecular weight formula_weight	124516.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MDDALHALSSLTAKKRTTTYKKVAVPILDENDNTNGNGPNDIDNPPELTGNGFLFANATLNRVKNRLEGKKAPEQNHNNGKDRSENSLPTQLISNLYDGGEELEKSEVKDNSYSEKNVSSSFTQTQRIPVSIQQDKVFNVPIHSVNDGKPTQLIKEDGLVNETSQALKTPLTTGRPGATQRIDSSGATSQTQPIKSIEPQSQIITTSSNHSNALSPKIPIIPTELIGTSPLFQSIQNRGPDTQMDVPPQTAHDEDKTQAIGIPQATHQEQKTQIDTVAQTLQDEVPHTLKIREIQSELASEDSKREKARNVEYKKPQKPIPTKKFFSKESFLADFDDSSSNEDDDIKLENAHPKPVQNDDELHENKSVELNLTDETRINEKRVPLLSSYANNLKREIDSSKCITLDLDSDSDEYGDDDMDSIKLSKDESVLPISQLSKATILNLKARLSKQNQKLSQRPNKSKDPKVDHNVLLNTLRKASRKQILDHQKEVIETKGLKLEDMAKEKEIVENLLEQEILRNKRIRQKEKRREKLEENDFQLNAHDSGSDSGSESSGFALSGNEIADYESSGSENDNRRESDSEKEDDEIILKQKKSHHVKHIINESDSDTEVEAKPKEKADESLPKRIAINLGHYGDNIGEDTDKFQETNVLDTQNIEEVMAERNTIENEVKDDVYVNEEADEAIRRQLIDKEKLQLKQKEKEHEAKIKELKKRGVTNFFEMEAEESEDEWHGIGGADGEGSDDYDSDLEKMIDDYSKNNFNPHEIREMLAAENKEMDIKMINKILYDIKNGGFRNKRAKNSLELELSDDDEDDVLQQYRLKRRELMRKRRLEIGDDAKLVKNPKSSAFFESMVEDIIEYKNPFGAEEEYNLDITSTATDLDTQDNSINVGDNTGNNEQKPVDQKNKKVIISEDFVQKSLSFLKSNNYEDFETDKELSRIQHGNDEAIEDLYTLKQNSSIKSFTNSQTDSTTSKTVNTIIDLEKRPEDEDEVENGDTSLVGVFKHPSIIKSFASRTDINDKFKEGNKTVKILKSYKTVGSSKASITYMGKTRKLIAPKRKTEGSHRYHHDHHNKKMKMKTKTKSNKLFESGQDSFDN

Entity 18 Entity 18 polymer

Description description	FACT complex subunit SPT16
Molecular weight formula_weight	118777.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MEELNIDFDVFKKRIELLYSKYNEFEGSPNSLLFVLGSSNAENPYQKTTILHNWLLSYEFPATLIALVPGKVIIITSSAKAKHLQKAIDLFKDPESKITLELWQRNNKEPELNKKLFDDVIALINSAGKTVGIPEKDSYQGKFMTEWNPVWEAAVKENEFNVIDISLGLSKVWEVKDVNEQAFLSVSSKGSDKFMDLLSNEMVRAVDEELKITNAKLSDKIENKIDDVKFLKQLSPDLSALCPPNYKFNFDLLDWTYSPIIQSGKKFDLRVSARSTNDQLYGNGCILASCGIRYNNYCSNITRTFLIDPSEEMANNYDFLLTLQKEIVTNILKPGRTPKEVYESVIEYIEKTKPELVPNFTKNIGSLIGLEFRDSNFILNVKNDYRKIQRGDCFNISFGFNNLKDSQSANNYALQLADTVQIPLDETEPPRFLTNYTKAKSQISFYFNNEEEDNNKKKSSPATKVPSKPDRNSKILRTKLRGEARGGAEDAQKEQIRKENQKKLHEKLEKNGLLRFSAADANGPDSEPRQYFKKYESYVRDSQLPTNIRDLRIHVDWKSQTIILPIYGRPVPFHINSYKNGSKNEEGEYTYLRLNFNSPGSSGGISKKVEELPYEESADNQFVRSITLRSKDGDRMSETFKQIADLKKEATKREQERKALADVVQQDKLIENKTGRTKRLDQIFVRPNPDTKRVPSTVFIHENGIRFQSPLRTDSRIDILFSNIKNLIFQSCKGELIVVIHIHLKNPILMGKKKIQDVQFYREASDMSVDETGGGRRGQSRFRRYGDEDELEQEQEERRKRAALDKEFKYFADAIAEASNGLLTVENTFRDLGFQGVPNRSAVFCMPTTDCLVQLIEPPFLVINLEEVEICILERVQFGLKNFDMVFVYKDFNKPVTHINTVPIESLDFLKQWLTDMDIPYTVSTINLNWATIMKSLQDDPYQFFLDGGWNFLATGSDDEASDESEEEVSEYEASEDDVSDESAFSEDEEGSEVDDDISGDESEDYTGDESEEGEDWDELEKKAARADRGANFRD

Entity 19 Entity 19 polymer

Description description	FACT complex subunit POB3
Molecular weight formula_weight	63068.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MSTDFDRIYLNQSKFSGRFRIADSGLGWKISTSGGSAANQARKPFLLPATELSTVQWSRGCRGYDLKINTKNQGVIQLDGFSQDDYNLIKNDFHRRFNIQVEQREHSLRGWNWGKTDLARNEMVFALNGKPTFEIPYARINNTNLTSKNEVGIEFNIQDEEYQPAGDELVEMRFYIPGVIQTNVDENMTKKEESSNEVVPKKEDGAEGEDVQMAVEEKSMAEAFYEELKEKADIGEVAGDAIVSFQDVFFTTPRGRYDIDIYKNSIRLRGKTYEYKLQHRQIQRIVSLPKADDIHHLLVLAIEPPLRQGQTTYPFLVLQFQKDEETEVQLNLEDEDYEENYKDKLKKQYDAKTHIVLSHVLKGLTDRRVIVPGEYKSKYDQCAVSCSFKANEGYLYPLDNAFFFLTKPTLYIPFSDVSMVNISRAGQTSTSSRTFDLEVVLRSNRGSTTFANISKEEQQLLEQFLKSKNLRVKNEDREVQERLQTALGSDSDEEDINMGSAGEDDESVDEDFQVSSDNDADEVAEEFDSDAALSDAEGGSDEERPSKKPKVE

Entity 20 Entity 20 polymer

Description description	Histone H3
Molecular weight formula_weight	15391.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,R

MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLVSLFEDTNLAAIHAKRVTIQKKDIKLARRLRGERS

Entity 21 Entity 21 polymer

Description description	Histone H4
Molecular weight formula_weight	11395.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O,S

MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEEVRAVLKSFLESVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG

Entity 22 Entity 22 polymer

Description description	Histone H2A.1
Molecular weight formula_weight	14013.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MSGGKGGKAGSAAKASQSRSAKAGLTFPVGRVHRLLRRGNYAQRIGSGAPVYLTAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHQNLLPKKSAKATKASQEL

Entity 23 Entity 23 polymer

Description description	Histone H2B.2
Molecular weight formula_weight	14264.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MSSAAEKKPASKAPAEKKPAAKKTSTSVDGKKRSKVRKETYSSYIYKVLKQTHPDTGISQKSMSILNSFVNDIFERIATEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSSTQA

Entity 24 Entity 24 polymer

Description description	DNA (51-MER)
Molecular weight formula_weight	15689.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	X

TTAAATTTTGCATACGATCGATTAATTTTTGAGTGTGTTTTTTTTTTTTTT

Entity 25 Entity 25 polymer

Description description	DNA (39-MER)
Molecular weight formula_weight	11935.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	Y

CACACACTCAAAAATTAATCGATCGTATGCAAAATTTAA

Entity 26 Entity 26 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	7

Entity 27 Entity 27 non-polymer

Description description	ADENOSINE-5'-DIPHOSPHATE
Molecular weight formula_weight	427.2 kDa
Source method src_method	syn
Copy count entity_count	5

▶

Resolution resolution	3.70 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	524000

Structure of yeast replisome associated with FACT and histone hexamer, Composite map

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Minichromosome maintenance protein 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA polymerase epsilon catalytic subunit A

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA polymerase epsilon subunit B

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer