7pmk

S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM2

Saccharomyces cerevisiae

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q1S9_YEASX
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 2； PDBConstruct 1–868； UniProt 1–868

DNA replication licensing factor MCM3

Saccharomyces cerevisiae

UniProt P24279

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM3_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 3； PDBConstruct 39–1009； UniProt 1–971

DNA replication licensing factor MCM4

Saccharomyces cerevisiae

UniProt P30665

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM4_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 4； PDBConstruct 1–933； UniProt 1–933

DNA helicase

Saccharomyces cerevisiae

UniProt A0A6A5PUY8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5PUY8_YEASX
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 5； PDBConstruct 1–775； UniProt 1–775

DNA replication licensing factor MCM6

Saccharomyces cerevisiae

UniProt P53091

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM6_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 6； PDBConstruct 1–1017； UniProt 1–1017

DNA replication licensing factor MCM7

Saccharomyces cerevisiae

UniProt A0A6A5Q4N0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q4N0_YEASX
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 7； PDBConstruct 1–845； UniProt 1–845

DNA replication complex GINS protein PSF1

Saccharomyces cerevisiae

UniProt A0A6A5Q203

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q203_YEASX
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain A； PDBConstruct 1–208； UniProt 1–208

DNA replication complex GINS protein PSF2

Saccharomyces cerevisiae

UniProt A0A6A5PX40

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5PX40_YEASX
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain B； PDBConstruct 1–213； UniProt 1–213

DNA replication complex GINS protein PSF3

Saccharomyces cerevisiae

UniProt A0A6L1BWJ4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6L1BWJ4_YEASX
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain C； PDBConstruct 1–194； UniProt 23–216

DNA replication complex GINS protein SLD5

Saccharomyces cerevisiae

UniProt Q03406

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SLD5_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain D； PDBConstruct 1–294； UniProt 1–294

Cell division control protein 45,Cell division control protein 45

Saccharomyces cerevisiae

UniProt Q08032

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC45_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain E； PDBConstruct 1–197； UniProt 1–197 Author chain E； PDBConstruct 210–657； UniProt 203–650

DNA polymerase alpha-binding protein

Saccharomyces cerevisiae

UniProt A0A6A5Q5Y5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q5Y5_YEASX
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain F； PDBConstruct 36–962； UniProt 1–927 Author chain G； PDBConstruct 36–962； UniProt 1–927 Author chain H； PDBConstruct 36–962； UniProt 1–927

E3 ubiquitin ligase complex SCF subunit

Saccharomyces cerevisiae

UniProt A0A6A5Q435

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A6A5Q435_YEASX
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain K； PDBConstruct 1–194； UniProt 1–194

Protein DIA2

Saccharomyces cerevisiae

UniProt Q08496

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DIA2_YEAST
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain L； PDBConstruct 4–735； UniProt 1–732

DNA polymerase epsilon catalytic subunit A

Saccharomyces cerevisiae

UniProt P21951

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DPOE_YEAST
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain Q； PDBConstruct 1–2222； UniProt 1–2222

DNA polymerase epsilon subunit B

Saccharomyces cerevisiae

UniProt P24482

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） Topoisomerase 1-associated factor 1 × 1 （P53840） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DPB2_YEAST
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain R； PDBConstruct 1–689； UniProt 1–689

Topoisomerase 1-associated factor 1

Saccharomyces cerevisiae

UniProt P53840

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Chromosome segregation in meiosis protein 3 × 1 （Q04659） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TOF1_YEAST
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain X； PDBConstruct 1–1238； UniProt 1–1238

Chromosome segregation in meiosis protein 3

Saccharomyces cerevisiae

UniProt Q04659

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 20 DNA 2	DNA replication licensing factor MCM2 × 1 （A0A6A5Q1S9） DNA replication licensing factor MCM3 × 1 （P24279） DNA replication licensing factor MCM4 × 1 （P30665） DNA helicase × 1 （A0A6A5PUY8） DNA replication licensing factor MCM6 × 1 （P53091） DNA replication licensing factor MCM7 × 1 （A0A6A5Q4N0） DNA replication complex GINS protein PSF1 × 1 （A0A6A5Q203） DNA replication complex GINS protein PSF2 × 1 （A0A6A5PX40） DNA replication complex GINS protein PSF3 × 1 （A0A6L1BWJ4） DNA replication complex GINS protein SLD5 × 1 （Q03406） Cell division control protein 45,Cell division control protein 45 × 1 （Q08032） DNA polymerase alpha-binding protein × 3 （A0A6A5Q5Y5） Leading strand template DNA × 1 Lagging strand template DNA × 1 E3 ubiquitin ligase complex SCF subunit × 1 （A0A6A5Q435） Protein DIA2 × 1 （Q08496） DNA polymerase epsilon catalytic subunit A × 1 （P21951） DNA polymerase epsilon subunit B × 1 （P24482） Topoisomerase 1-associated factor 1 × 1 （P53840） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 7	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CSM3_YEAST
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain Y； PDBConstruct 3–319； UniProt 1–317

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7pmk
Deposition date deposition_date	2021-09-02
Structure title title	S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
Keywords keywords	Genome stability, DNA replication, Ubiquitination, termination, replisome, cryo-EM, CMG, SCF(Dia2), REPLICATION; REPLICATION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7pmk__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7pmk__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7pmk__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	74.76 Å
Rg (electron density)	75.00 Å
Total Rg	74.91 Å
Atom count	74697
Residues	9198
Excluded volume	1333900 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7pmk__assembly_1__model_1`	22-meric （22）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (23)

Entity 1 Entity 1 polymer

Description description	DNA replication licensing factor MCM2
Molecular weight formula_weight	98911.5 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2
Atom count atom_count	74697

MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPDIDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERDRLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREELTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIYTLGH

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 2 Entity 2 polymer

Description description	DNA replication licensing factor MCM3
Molecular weight formula_weight	111987.6 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEAPVMEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 3 Entity 3 polymer

Description description	DNA replication licensing factor MCM4
Molecular weight formula_weight	105138.4 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEGNIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSSSSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDPKTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVESSDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 4 Entity 4 polymer

Description description	DNA helicase
Molecular weight formula_weight	86505.7 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKRRLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 5 Entity 5 polymer

Description description	DNA replication licensing factor MCM6
Molecular weight formula_weight	113110.2 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6

MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGPFVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGNGTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKKKTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRLAFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 6 Entity 6 polymer

Description description	DNA replication licensing factor MCM7
Molecular weight formula_weight	95049.9 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7

MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKGPKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLSNCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDIDLQDA

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 7 Entity 7 polymer

Description description	DNA replication complex GINS protein PSF1
Molecular weight formula_weight	24230.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQLGMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDTNNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 8 Entity 8 polymer

Description description	DNA replication complex GINS protein PSF2
Molecular weight formula_weight	25096.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKALNNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWLVLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINELRPFITEIMDKLREIHTASLTAGTENDEEEFNI

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 9 Entity 9 polymer

Description description	DNA replication complex GINS protein PSF3
Molecular weight formula_weight	22004.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLNLPLWLARILAIVGGDEALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKELANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKSHESYKDTKRWMFKK

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 10 Entity 10 polymer

Description description	DNA replication complex GINS protein SLD5
Molecular weight formula_weight	33983.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDFSDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPNESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEIKYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKWNEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 11 Entity 11 polymer

Description description	Cell division control protein 45,Cell division control protein 45
Molecular weight formula_weight	75154.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDYKDDDGDYKDDDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 12 Entity 12 polymer

Description description	DNA polymerase alpha-binding protein
Molecular weight formula_weight	108610.1 kDa
Source method src_method	man
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,G,H

MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEMVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 13 Entity 13 polymer

Description description	Leading strand template DNA
Molecular weight formula_weight	37688.6 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	I

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGTTTTTGGGGGGGGGG

Entity 14 Entity 14 polymer

Description description	Lagging strand template DNA
Molecular weight formula_weight	35259.2 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	J

CCCCCCCCCCACCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

Entity 15 Entity 15 polymer

Description description	E3 ubiquitin ligase complex SCF subunit
Molecular weight formula_weight	22357.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MVTSNVVLVSGEGERFTVDKKIAERSLLLKNYLNDMHDSNLQNNSDSESDSDSETNHKSKDNNNGDDDDEDDDEIVMPVPNVRSSVLQKVIEWAEHHRDSNFPDEDDDDSRKSAPVDSWDREFLKVDQEMLYEIILAANYLNIKPLLDAGCKVVAEMIRGRSPEEIRRTFNIVNDFTPEEEAAIRRENEWAEDR

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 16 Entity 16 polymer

Description description	Protein DIA2
Molecular weight formula_weight	85368.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

GAGMSSPGNSGVAIDSTVLKAIELGTRLFKSGEYLQAKRIFTNALRVCDSYSQEQIMRIRNAYQLDTARPDNKRLYHPRYIKILDNICACYEKLNDLKSCLDVSQRLLKLEPGNIKCYIRCTRTLIKLKDWKRAYKTCSRGLQLCNNDSNHLRQQKQFIKNNMVQKQDGKRSYIDPLEETKIAKKKKNNNVLESLPKKKIKGSTKKTDLVGNLPIEILPIIFQRFTTKELVTLSLVCNKWRDKILYHLDCFQEFNLAPINFKNFVKFMDFLQQNFTRTYRKYILSQVKVSSRITSEELRITQLLFSKMPKCINIERLILSMPTLTTTQIFKLMVRGGTDFFTRLLELSLMITYRPDKQHELEILQTCPLLKKIELIFVNSLVPIFDGNNSVGRDGSFNVMARHTNMQISTADNDEQGIVEEKVIYSELEKITLICDKKKIKNFPLCRALLRGQFPLLQKLTITGVTFPMNNQDIMNFQWLLNFPDLKELWIEDNDNCELSKFLQLLKFSNVWKNLEKLTFRENKLYPIVNLDEDQPVTNDDEVPSMLFYKENLQNLEKLDLMGTSISGSALTRLCEQEYLDGRKLRSLNIGNCPNIQFPNNHAHTARMILDVNAVLKRLSKLEEINLSHLSSLNDSTMKSFIINVPFLENLKRLDISHNFEITGISIYEFLKKFQMDHDNEAGGQPLAYLNIDGCSQVSHITVNMIRAQNLVTQVDCVYERDVWRKFGINSYSYS

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 17 Entity 17 polymer

Description description	DNA polymerase epsilon catalytic subunit A
Molecular weight formula_weight	255890.4 kDa
EC 编号 ec_number	2.7.7.7,3.1.11.-
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MMFGKKKNNGGSSTARYSAGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIATKEDKFKQTSLTKFFSKTKNVPTMGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKRKRNQLTNEEDPLVLPSEIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNTNSSRERSALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQRAIMDLGASVTFRSKAMGALGKGIQQGFEMKDLSMAENERYLSGFSMDIGYLLHFPTSIGYEFFSLFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETYSYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSLNEVLLPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSDLVNNNMGIDDKDAVINSPSEFVHDAFSNDALNVLRGMLKEWWDEALKENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNSGTQRPTQIVNVKKQDKEDSVENSLNGFSHLFSKPLMKRVKKLFKNQQEFILDPQYEADYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKSTILEIRTLRKELLKIFELREFAKVAEFKDPSLSLVVPDFLCEYCFFISDIDFCKAAPESIFSCVRCHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPRESIVQKLNVFKQVAKYYGFDILLSCIADLTI

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 18 Entity 18 polymer

Description description	DNA polymerase epsilon subunit B
Molecular weight formula_weight	78425.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MFGSGNVLPVKIQPPLLRPLAYRVLSRKYGLSIKSDGLSALAEFVGTNIGANWRQGPATIKFLEQFAAVWKQQERGLFIDQSGVKEVIQEMKEREKVEWSHEHPIQHEENILGRTDDDENNSDDEMPIAADSSLQNVSLSSPMRQPTERDEYKQPFKPESSKALDWRDYFKVINASQQQRFSYNPHKMQFIFVPNKKQNGLGGIAGFLPDIEDKVQMFLTRYYLTNDRVMRNENFQNSDMFNPLSSMVSLQNELSNTNRQQQSSSMSITPIKNLLGRDAQNFLLLGLLNKNFKGNWSLEDPSGSVEIDISQTIPTQGHYYVPGCMVLVEGIYYSVGNKFHVTSMTLPPGERREITLETIGNLDLLGIHGISNNNFIARLDKDLKIRLHLLEKELTDHKFVILGANLFLDDLKIMTALSKILQKLNDDPPTLLIWQGSFTSVPVFASMSSRNISSSTQFKNNFDALATLLSRFDNLTENTTMIFIPGPNDLWGSMVSLGASGTLPQDPIPSAFTKKINKVCKNVVWSSNPTRIAYLSQEIVIFRDDLSGRFKRHRLEFPFNESEDVYTENDNMMSKDTDIVPIDELVKEPDQLPQKVQETRKLVKTILDQGHLSPFLDSLRPISWDLDHTLTLCPIPSTMVLCDTTSAQFDLTYNGCKVINPGSFIHNRRARYMEYVPSSKKTIQEEIYI

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 19 Entity 19 polymer

Description description	Topoisomerase 1-associated factor 1
Molecular weight formula_weight	141296.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MSADLQQGTTNAADFSLTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKRWFKLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLAAKLAKNNPDHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQLVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFRNVIAIEPGEFTINTKKSMPKKGITSIDTLPPNVSMDDISLNTVISSFHKNKVFGFLLTLTSSLSKEFDQDFINIPLLEIMFYFTKDVNQELLFPRQFETGTHSKVVNKNESSSANNIVTSAGFELSKLLQKEHQMRKNVIKHTSARHSRFGGLLSIQTPDKTRLTVSGSQALVDEKIALQKLDDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESNGKHFKEFINNFIDSGFNILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFVKYQLLRSKIDNSADIKQVSEALKEVTFILVSSLLRSAYDLKNWTVTHAGMIAFNELLNLVSRTKAAQEEDSTDIEFIVSRLFSDERIQLLSNLPKIGSKYSLQFMKSCIELTHSVLKVLEQYSDDKTLVIEGKSRRQKKFNISEGDITKLIEEENVDRDEALDILTSSLRSIEVNFQKVQANYMTEPVIETYINFLERFRELEDDSIKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRKYVSQFSDYFLARLKKRLKKSPAWFVGLLFPPLHNSEVGFYQRYGEYNVLNNESMYAAPASQFKPIPDEEALPPSILLDMKYGVLVSTLLDDGKTELLDQLLKHITHTLDIFKSWLTVNVNAGKETVNPPNEYFTLTGVLNNDPIFKDKDYRALLLLIGYSIPRKINEPCFLPGTVEVSDLTVSCELVKKYLSTPFETPNGLPSSSYLLRVRSEKDSFSHNEQDGWEGDDDYDYNDPYIVPDDQILSKSDAAYFKDLDNNASDKLKGTKFSKGIARSKKKDKRKRRKGEAKTNLPMFGDQDDERPQTVRERHGVFSKEFISDSEDDEDLMNPIFFENETYMRWLLDKNNGQLTEDRYIQFAKFAAERMNNGGVVTGDYTSLFGGSIPSIESIRATESSSFAPDKSLISLASHVASEMSIFDVNNNNNNQLSDDDVNSESRNSLGSSQPSNSQNMFQSEVYSRKESTKRSLEASAADESDEDEEAIRLFGKKSRVVLSQGDSDD

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 20 Entity 20 polymer

Description description	Chromosome segregation in meiosis protein 3
Molecular weight formula_weight	36588.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

GEMDQDFDSLLLGFNDSDSVQKDPTVPNGLDGSVVDPTIADPTAITARKRRPQVKLTAEKLLSDKGLPYVLKNAHKRIRISSKKNSYDNLSNIIQFYQLWAHELFPKAKFKDFMKICQTVGKTDPVLREYRVSLFRDEMGMSFDVGTRETGQDLERQSPMVEEHVTSAEERPIVADSFAQDKRNVNNVDYDNDEDDDIYHLSYRNRRGRVLDERGNNETVLNNVVPPKEDLDALLKTFRVQGPVGLEENEKKLLLGWLDAHRKMEKGSMTEEDVQLIQSLEEWEMNDIEGQHTHYDLLPGGDEFGVDQDELDAMKEMGF

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Saccharomyces cerevisiae

Entity 21 Entity 21 non-polymer

Description description	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Molecular weight formula_weight	506.2 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 22 Entity 22 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 23 Entity 23 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	7

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.20 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	369254

S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA helicase

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein SLD5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer