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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q02790 New Search
12PDB entries
15Biological assembly
20chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1N1A Crystal Structure of the N-terminal domain of human FKBP52 Deposited 2002-10-16 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–139（139 aa） Fragment：the N-terminal fragment (1-140)
Chain B 1–139（139 aa） Fragment：the N-terminal fragment (1-140)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；Tris-HCl, Ammonium Sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 2.40 Å R-free 0.280
1P5Q Crystal Structure of FKBP52 C-terminal Domain Deposited 2003-04-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 145–458（314 aa） Fragment：FKBP52 C-TERMINAL DOMAIN
Chain B 145–458（314 aa） Fragment：FKBP52 C-TERMINAL DOMAIN
Chain C 145–458（314 aa） Fragment：FKBP52 C-TERMINAL DOMAIN
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 18 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；Ammonium Sulfate, Tris, Ethanol, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 2.80 Å R-free 0.284
1Q1C Crystal structure of N(1-260) of human FKBP52 Deposited 2003-07-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–259（259 aa） Fragment：RESIDUES (-19)-260
Not recorded DMS DIMETHYL SULFOXIDE × 5 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；PEG6000, Tris, DMSO, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 1.90 Å R-free 0.247
1QZ2 Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90 Deposited 2003-09-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 144–458（315 aa） Fragment：FKBP52 C-terminal Domain
Chain B 144–458（315 aa） Fragment：FKBP52 C-terminal Domain
Chain C 144–458（315 aa） Fragment：FKBP52 C-terminal Domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；Sodium Citrate, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 3.00 Å R-free 0.287
4DRJ o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR Deposited 2012-02-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–140（140 aa） Fragment：Fk1 domain, UNP residues 1-140
Not recorded RAP RAPAMYCIN IMMUNOSUPPRESSANT DRUG × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；293 K；0.1M BisTris, 1.95M (NH4)2SO4, pH 6.5, vapor diffusion, temperature 293K
Resolution 1.80 Å R-free 0.225
4LAV Crystal Structure Analysis of FKBP52, Crystal Form II Deposited 2013-06-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 16–260（245 aa） Fragment：UNP residues 16-260
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；2 M ammonium sulfate, 0.1 M Bis-Tris, pH 6.5, VAPOR DIFFUSION, temperature 293K
Resolution 1.80 Å R-free 0.235
4LAV Crystal Structure Analysis of FKBP52, Crystal Form II Deposited 2013-06-20 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 16–260（245 aa） Fragment：UNP residues 16-260
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；2 M ammonium sulfate, 0.1 M Bis-Tris, pH 6.5, VAPOR DIFFUSION, temperature 293K
Resolution 1.80 Å R-free 0.235
4LAW Crystal Structure Analysis of FKBP52, Crystal Form III Deposited 2013-06-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 16–260（245 aa） Fragment：UNP residues 16-260
Not recorded DMS DIMETHYL SULFOXIDE × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；25% PEG6000, 0.1 M Tris-HCl, pH 8.0, 5% DMSO, VAPOR DIFFUSION, temperature 293K
Resolution 2.40 Å R-free 0.282
4LAW Crystal Structure Analysis of FKBP52, Crystal Form III Deposited 2013-06-20 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 16–260（245 aa） Fragment：UNP residues 16-260
Not recorded DMS DIMETHYL SULFOXIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；25% PEG6000, 0.1 M Tris-HCl, pH 8.0, 5% DMSO, VAPOR DIFFUSION, temperature 293K
Resolution 2.40 Å R-free 0.282
4LAX Crystal Structure Analysis of FKBP52, Complex with FK506 Deposited 2013-06-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 16–260（245 aa） Fragment：UNP residues 16-260
Not recorded FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 DMS DIMETHYL SULFOXIDE × 3 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；25% PEG6000, 0.1 M Tris-HCl, pH 8.0, 5% DMSO, VAPOR DIFFUSION, temperature 293K
Resolution 2.01 Å R-free 0.219
4LAY Crystal Structure Analysis of FKBP52, Complex with I63 Deposited 2013-06-20 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–260（260 aa） Fragment：UNP residues 1-260
Not recorded I63 {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；293 K；25% PEG6000, 0.1 M Tris-HCl, pH 8.0, 4% DMSO, VAPOR DIFFUSION, temperature 293K
Resolution 1.70 Å R-free 0.205
4TW8 The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL Deposited 2014-06-30 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count
Chain A 21–255（235 aa） Fragment：UNP residues 21-255
Not recorded 37M 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；28 % PEG-6000, 2 % DMSO and TrisHCl pH 8.0
Resolution 3.00 Å R-free 0.257
4TW8 The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL Deposited 2014-06-30 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: Monomeric（1） Consistent with protein count
Chain B 21–255（235 aa） Fragment：UNP residues 21-255
Not recorded 37M 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；28 % PEG-6000, 2 % DMSO and TrisHCl pH 8.0
Resolution 3.00 Å R-free 0.257
6RCY CRYSTAL STRUCTURE OF FK1 DOMAIN OF FKBP52 IN COMPLEX WITH A BIO-INSPIRED HYBRID FLUORESCENT LIGAND Deposited 2019-04-12 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–148（148 aa）
Not recorded K0T (2~{S})-5-carbamimidamido-2-[[(2~{S})-2-[[(2~{S})-1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-2-yl]carbonylamino]-4-phenyl-butanoyl]amino]pentanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.8M potassium phosphate, 0.8M sodium phosphate, 0.1M HEPES, pH 7.5
Resolution 2.30 Å R-free 0.244
8FFV Cryo-EM structure of the GR-Hsp90-FKBP52 complex Deposited 2022-12-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain D 1–459（459 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 DEX DEXAMETHASONE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.