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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q04656 New Search
22PDB entries
22Biological assembly
22chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1AW0 FOURTH METAL-BINDING DOMAIN OF THE MENKES COPPER-TRANSPORTING ATPASE, NMR, 20 STRUCTURES Deposited 1997-10-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 375–446（72 aa） Fragment：FOURTH METAL-BINDING DOMAIN
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.8；300 K
Resolution not provided
1KVI Solution Structure of the Reduced Form of the First Heavy Metal Binding Motif of the Menkes Protein Deposited 2002-01-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–79（79 aa） Fragment：RESIDUES 1-79
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Pressure 1
NMR sample composition 20 mM NaAcetate buffer, 10 mM DTT, 1 mM EDTA, 0.01% Na Azide, 1 mM Protein | H2O/D2O
Resolution not provided
1KVJ Solution Structure of the Cu(I) bound form of the first heavy metal binding motif of the Menkes protein Deposited 2002-01-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–79（79 aa） Fragment：RESIDUES 1-79
Not recorded CU1 COPPER (I) ION × 1 SOLUTION NMR
NMR measurement conditions pH 6.5；295 K；Pressure 1
NMR sample composition 20 mM Na Acetate buffer, 10 mM DTT, 1 mM EDTA, 0.01% Na Azide, 1 mM Protein | H2O/D2O
Resolution not provided
1Q8L Second Metal Binding Domain of the Menkes ATPase Deposited 2003-08-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 164–246（83 aa） Fragment：Second Copper Binding Domain (residues 164-246)
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 30mM；Pressure ambient
NMR sample composition 0.5mM MNKr2, U-15N, 20mM potassium phosphate, 10 mM Sodium Chloride, pH6.5. | 90% H2O/10% D2O
Resolution not provided
1S6O Solution structure and backbone dynamics of the apo-form of the second metal-binding domain of the Menkes protein ATP7A Deposited 2004-01-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 169–240（72 aa） Fragment：Second soluble domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) phosphate 100 mM；Pressure ambient
NMR sample composition 1 mM protein, pH 7 | 90% H2O/10% D2O
NMR sample composition 1 mM protein U-15N, pH 7 | 90% H2O/10% D2O
NMR sample composition 1 mM protein U-15N,13C, pH 7 | 90% H2O/10% D2O
Resolution not provided
1S6U Solution structure and backbone dynamics of the Cu(I) form of the second metal-binding domain of the Menkes protein ATP7A Deposited 2004-01-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 169–240（72 aa） Fragment：Second domain of ATP7A
Not recorded CU1 COPPER (I) ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100 mM phosphate；Pressure ambient
NMR sample composition 1 mM protein, 1:1 copper(I) | 90% H2O/10% D2O
NMR sample composition 1 mM protein U-15N, 1:1 copper(I) | 90% H2O/10% D2O
NMR sample composition 1 mM protein U-15N,13C, 1:1 copper(I) | 90% H2O/10% D2O
Resolution not provided
1Y3J Solution structure of the copper(I) form of the fifth domain of Menkes protein Deposited 2004-11-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 486–558（73 aa） Fragment：fifth domain of the menkes protein
Not recorded CU COPPER (II) ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 50mM sodium phosphate；Pressure ambient
NMR sample composition 1mM MNK5 domain U-15N,13C; 50mM phosphate buffer NA | 90% H2O/10% D2O
Resolution not provided
1Y3K Solution structure of the apo form of the fifth domain of Menkes protein Deposited 2004-11-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 486–558（73 aa） Fragment：fifth domain of the menkes protein
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 50mM sodium phosphate；Pressure ambient
NMR sample composition 1mM MNK5 domain U-15N,13C; 50mM phosphate buffer NA | 90% H2O/10% D2O
Resolution not provided
1YJR Solution structure of the apo form of the sixth soluble domain A69P mutant of Menkes protein Deposited 2005-01-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 562–633（72 aa） Fragment：Sixth soluble domain
Mutation：A69P No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100 mM phosphate buffer；Pressure ambient
NMR sample composition 0.8mM 15N labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 0.8mM 15N 13C labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 1.0mM unlabeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
Resolution not provided
1YJT Solution structure of the Cu(I) form of the sixth soluble domain A69P mutant of Menkes protein Deposited 2005-01-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 562–633（72 aa） Fragment：Sixth soluble domain
Mutation：A69P CU1 COPPER (I) ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100mM phosphate buffer；Pressure ambient
NMR sample composition 0.8mM 15N labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 0.8mM 15N 13C labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 1.0mM unlabeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
Resolution not provided
1YJU Solution structure of the apo form of the sixth soluble domain of Menkes protein Deposited 2005-01-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 562–633（72 aa） Fragment：Sixth soluble domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100mM phosphate buffer；Pressure ambient
NMR sample composition 0.8mM 15N labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 0.8mM 15N 13C labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 1.0mM unlabeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
Resolution not provided
1YJV Solution structure of the Cu(I) form of the sixth soluble domain of Menkes protein Deposited 2005-01-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 562–633（72 aa） Fragment：Sixth soluble domain
Not recorded CU1 COPPER (I) ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100mM phosphate buffer；Pressure ambient
NMR sample composition 0.8mM 15N labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 0.8mM 15N 13C labeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
NMR sample composition 1.0mM unlabeled sample; 5mM DTT; 100mM phosphate buffer | 90% H2O/10% D2O
Resolution not provided
2AW0 FOURTH METAL-BINDING DOMAIN OF THE MENKES COPPER-TRANSPORTING ATPASE, NMR, 20 STRUCTURES Deposited 1997-10-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 375–446（72 aa） Fragment：FOURTH METAL-BINDING DOMAIN
Not recorded AG SILVER ION × 1 SOLUTION NMR
NMR measurement conditions pH 6.8；300 K
Resolution not provided
2G9O Solution structure of the apo form of the third metal-binding domain of ATP7A protein (Menkes Disease protein) Deposited 2006-03-07 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 275–352（78 aa） Fragment：sixth soluble domain, residues 275-352
Mutation：K46V No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100mM phosphate buffer；Pressure ambient
NMR sample composition 1.5mM Apo-MNK3 unlabelled sample, 100mM phosphate buffer, pH 7.0, 1mM DTT,90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM Apo-MNK3 15N labelled sample, 100mM phosphate buffer, pH 7.0, 1mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 1mM Apo-MNK3 15N, 13C labelled sample, 100mM phosphate buffer, pH 7.0, 1mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2GA7 Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein) Deposited 2006-03-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 275–352（78 aa） Fragment：Third soluble domain, residues 275-352
Mutation：K46V CU1 COPPER (I) ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 100mM phosphate buffer；Pressure ambient
NMR sample composition 1mM copper(I)MNK3 unlabelled sample, 100mM phosphate buffer, pH 7.0, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 0.5mM copper(I)MNK3 15N labeled sample, 100mM phosphate buffer, pH 7.0, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 0.5mM copper(I)MNK3 15N,13C labeled sample, 100mM phosphate buffer, pH 7.0, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2K1R The solution NMR structure of the complex between MNK1 and HAH1 mediated by Cu(I) Deposited 2008-03-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 5–77（73 aa） Fragment：HMA 1 domain: Residues 5-77
Not recorded CU COPPER (II) ION × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Pressure ambient
NMR measurement conditions pH 7；298 K；Pressure ambient
NMR measurement conditions pH 7；298 K；Pressure ambient
NMR measurement conditions pH 7；298 K；Pressure ambient
NMR sample composition 0.6 mM MNK1, 0.6 mM [U-100% 13C; U-100% 15N] HAH1, 0.6 mM COPPER(I) ION, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.6 mM [U-100% 13C; U-100% 15N] MNK1, 0.6 mM HAH1, 0.6 mM COPPER(I) ION, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.6 mM [U-100% 13C; U-100% 15N] MNK1, 1.0 mM HAH1, 1.0 mM COPPER(I) ION, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1.0 mM MNK1, 0.6 mM [U-100% 13C; U-100% 15N] HAH1, 1.0 mM COPPER(I) ION, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2KIJ Solution structure of the Actuator domain of the copper-transporting ATPase ATP7A Deposited 2009-05-06 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 806–924（119 aa） Fragment：actuator domain, UNP residues 806-924
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) phosphate, arginine, glutamate；Pressure ambient
NMR sample composition 0.3 mM Actd-1, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.3 mM [U-13C; U-15N] Actd-2, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.3 mM [U-15N] Actd-3, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2KMV Solution structure of the nucleotide binding domain of the human Menkes protein in the ATP-free form Deposited 2009-08-05 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1051–1231（181 aa） Fragment：nucleotide binding domain
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) phospate 0.05；Pressure ambient
NMR sample composition 1.5 mM [U-99% 15N] ATPfree N-MNK-1, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.8 mM [U-95% 13C; U-95% 15N] ATPfree N-MNK-2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2KMX Solution structure of the nucleotide binding domain of the human Menkes protein in the ATP-bound form Deposited 2009-08-05 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1051–1231（181 aa） Fragment：nucleotide binding domain
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) phospate 0.05；Pressure ambient
NMR sample composition 1.5 mM [U-99% 15N] ATPfree N-MNK-1, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.8 mM [U-95% 13C; U-95% 15N] ATPfree N-MNK-2, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3CJK Crystal structure of the adduct HAH1-Cd(II)-MNK1. Deposited 2008-03-13 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 7–77（71 aa）
Not recorded CD CADMIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.7；298 K；0.1 M sodium citrate, 20% PEG-6000, pH 4.7, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.80 Å R-free 0.283
5T7L Pt(II)-mediated copper-dependent interactions between ATOX1 and MNK1 Deposited 2016-09-05 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 7–77（71 aa） Fragment：UNP residues 7-77
Not recorded PT PLATINUM (II) ION × 2 CU COPPER (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；PEG-6000 10 to 30 % w/v and sodium citrate 0.1M at pH 4.7
Resolution 2.83 Å R-free 0.273
7LU8 Structure of the cryptic HMA domain of the human copper transporter ATP7A Deposited 2021-02-21 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 84–156（73 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 210；Pressure 1
NMR sample composition 0.35 mM [U-13C; U-15N] HMA2A, 50 mM HEPES, 150 mM sodium chloride, 5 mM TCEP, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.