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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q13043 New Search
10PDB entries
18Biological assembly
27chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2JO8 Solution structure of C-terminal domain of human mammalian sterile 20-like kinase 1 (MST1) Deposited 2007-02-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 432–480（49 aa） Fragment：C-terminal SARAH domain, database residues 432-480
Chain B 432–480（49 aa） Fragment：C-terminal SARAH domain, database residues 432-480
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 125；Pressure AMBIENT
NMR sample composition 1 mM [U-13C; U-15N] c-terminal domain of Mammalian sterile 20-like kinase 1, 100 mM sodium chloride, 2 mM DTT, 25 mM HEPES, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3COM Crystal structure of Mst1 kinase Deposited 2008-03-28 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–311（310 aa） Fragment：Protein kinase domain: Residues 2-311
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 10.5；294 K；1700mM Ammonium sulfate, 300mM Lithium sulfate, 100mM CAPS pH 10.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 2.20 Å R-free 0.244
3COM Crystal structure of Mst1 kinase Deposited 2008-03-28 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 2–311（310 aa） Fragment：Protein kinase domain: Residues 2-311
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 10.5；294 K；1700mM Ammonium sulfate, 300mM Lithium sulfate, 100mM CAPS pH 10.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 2.20 Å R-free 0.244
4NR2 Crystal structure of STK4 (MST1) SARAH domain Deposited 2013-11-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Chain B 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Not recorded EDO 1,2-ETHANEDIOL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；277.15 K；2.3M sodium formate, 0.1M acetate pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 2.00 Å R-free 0.240
4NR2 Crystal structure of STK4 (MST1) SARAH domain Deposited 2013-11-26 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Chain D 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Not recorded EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；277.15 K；2.3M sodium formate, 0.1M acetate pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 2.00 Å R-free 0.240
4NR2 Crystal structure of STK4 (MST1) SARAH domain Deposited 2013-11-26 Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Chain F 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Not recorded EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；277.15 K；2.3M sodium formate, 0.1M acetate pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 2.00 Å R-free 0.240
4NR2 Crystal structure of STK4 (MST1) SARAH domain Deposited 2013-11-26 Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain G 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Chain H 432–480（49 aa） Fragment：SARAH domain, UNP residues 432-480
Not recorded EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；277.15 K；2.3M sodium formate, 0.1M acetate pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 277.15K
Resolution 2.00 Å R-free 0.240
4OH8 Crystal Structure of the human MST1-RASSF5 SARAH heterodimer Deposited 2014-01-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 432–480（49 aa） Fragment：MST1 SARAH domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.8；293 K；35% (v/v) 2-methyl-2,4-pentanediol (MPD) acetate, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.28 Å R-free 0.278
6YAT Crystal structure of STK4 (MST1) in complex with compound 6 Deposited 2020-03-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–311（311 aa）
Chain B 1–311（311 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) 3FX (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid × 1 GOL GLYCEROL × 7 OJ5 4-[5-(3-chlorophenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 11；293.15 K；0.6 M ammonium sulfate, 0.1 M lithium sulfate and 0.1 M CAPS, pH 11.0
Resolution 2.58 Å R-free 0.259
8A5J Crystal structure of Human STE20-like kinase 1, MST1 in complex with compound XMU-MP-1 Deposited 2022-06-15 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 28–309（282 aa）
Chain B 28–309（282 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) 5BS 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2M Ammonium citrate pH 7.0, 18% PEG3350
Resolution 2.12 Å R-free 0.248
8PAV Crystal structure of MST1 with a MAP4K1 SMOL inhibitor Deposited 2023-06-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–311（311 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) XOZ 1-[3,5-bis(fluoranyl)-4-[[3-(1,3-thiazol-5-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.4 M NH4SO4, 0.3 M LiSO4, 0.1 M CAPS pH 9.8
Resolution 1.90 Å R-free 0.212
8PAV Crystal structure of MST1 with a MAP4K1 SMOL inhibitor Deposited 2023-06-08 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–311（311 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) XOZ 1-[3,5-bis(fluoranyl)-4-[[3-(1,3-thiazol-5-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea × 1 GOL GLYCEROL × 1 CXS 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.4 M NH4SO4, 0.3 M LiSO4, 0.1 M CAPS pH 9.8
Resolution 1.90 Å R-free 0.212
8PAW Crystal structure of MST1 with a MAP4K1 SMOL inhibitor Deposited 2023-06-08 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–311（311 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) ASP ASPARTIC ACID × 1 XQL 1-[3,5-bis(fluoranyl)-4-[[3-(1-propan-2-ylpyrazol-3-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea × 1 GOL GLYCEROL × 1 CXS 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.4 M NH4SO4, 0.3 M LiSO4, 0.1 M CAPS pH 9.8
Resolution 2.14 Å R-free 0.226
8PAW Crystal structure of MST1 with a MAP4K1 SMOL inhibitor Deposited 2023-06-08 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–311（311 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) XQL 1-[3,5-bis(fluoranyl)-4-[[3-(1-propan-2-ylpyrazol-3-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea × 1 GOL GLYCEROL × 1 CXS 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；1.4 M NH4SO4, 0.3 M LiSO4, 0.1 M CAPS pH 9.8
Resolution 2.14 Å R-free 0.226
9IIC Crystal structure of HOIP RING2-LDD in complex with STK4 KD domain Deposited 2024-06-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 11–311（301 aa） Fragment：KD domain
Mutation：K59R GOL GLYCEROL × 1 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；0.2 M Ammonium citrate tribasic (pH 7.0), 20% w/v Polyethylene glycol 3350
Resolution 2.78 Å R-free 0.280
9IIC Crystal structure of HOIP RING2-LDD in complex with STK4 KD domain Deposited 2024-06-20 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 11–311（301 aa） Fragment：KD domain
Mutation：K59R GOL GLYCEROL × 1 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；0.2 M Ammonium citrate tribasic (pH 7.0), 20% w/v Polyethylene glycol 3350
Resolution 2.78 Å R-free 0.280
9VX3 Crystal structure of the peptide-bound form of HisMab-1 Fv-clasp Deposited 2025-07-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 432–480（49 aa）
Chain B 432–480（49 aa）
Mutation：S37C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；16% (w/v) polyethylene glycol 3350, 0.1M HEPES (pH 7.0), 0.2M MgCl2
Resolution 2.39 Å R-free 0.237
9VX3 Crystal structure of the peptide-bound form of HisMab-1 Fv-clasp Deposited 2025-07-18 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 432–480（49 aa）
Chain E 432–480（49 aa）
Mutation：S37C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；16% (w/v) polyethylene glycol 3350, 0.1M HEPES (pH 7.0), 0.2M MgCl2
Resolution 2.39 Å R-free 0.237

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.