Current Protein Identity：Q15382
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1XTQ Structure of small GTPase human Rheb in complex with GDP Deposited 2004-10-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：GTPase domain
|
Not recorded | MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；277 K；potassium dihydrogenphosphate, PEG 8000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.257 |
| 1XTR Structure of small GTPase human Rheb in complex with GppNHp Deposited 2004-10-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：GTPase domain
|
Not recorded | MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；277 K；potassium dihydrogenphosphate, PEG 8000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.65 Å R-free 0.270 |
| 1XTS Structure of small GTPase human Rheb in complex with GTP Deposited 2004-10-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：GTPase domain
|
Not recorded | MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；277 K；ammonium dihydrogenphosphate, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.277 |
| 3SEA Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms Deposited 2011-06-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
3–169（167 aa）
Fragment：G-domain
|
Mutation：Y35A | MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris hydrochloride, 200 mM Sodium acetate trihydrate, 30% w/v Polyethylene glycol 4,000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.214 |
| 3SEA Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms Deposited 2011-06-10 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
3–169（167 aa）
Fragment：G-domain
|
Mutation：Y35A | MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris hydrochloride, 200 mM Sodium acetate trihydrate, 30% w/v Polyethylene glycol 4,000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.214 |
| 3SEA Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms Deposited 2011-06-10 | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
3–169（167 aa）
Fragment：G-domain
Chain B
3–169（167 aa）
Fragment：G-domain
|
Mutation：Y35A Mutation：Y35A | MG MAGNESIUM ION × 4 GDP GUANOSINE-5'-DIPHOSPHATE × 2 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 ACT ACETATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris hydrochloride, 200 mM Sodium acetate trihydrate, 30% w/v Polyethylene glycol 4,000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.214 |
| 3T5G Structure of fully modified farnesylated Rheb in complex with PDE6D Deposited 2011-07-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–181（181 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 FAR FARNESYL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Tris 8.5, and 12.5 % PEG8000, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.235 |
| 5YXH Structure of Rheb-GDP Deposited 2017-12-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–169（168 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；25% w/v PEG 1500
|
Resolution 2.04 Å R-free 0.299 |
| 5YXH Structure of Rheb-GDP Deposited 2017-12-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–169（168 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；25% w/v PEG 1500
|
Resolution 2.04 Å R-free 0.299 |
| 5YXH Structure of Rheb-GDP Deposited 2017-12-05 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
2–169（168 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；25% w/v PEG 1500
|
Resolution 2.04 Å R-free 0.299 |
| 5YXH Structure of Rheb-GDP Deposited 2017-12-05 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
2–169（168 aa）
|
Not recorded | GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；25% w/v PEG 1500
|
Resolution 2.04 Å R-free 0.299 |
| 6BCU Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom Deposited 2017-10-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count |
Chain R
1–184（184 aa）
Chain S
1–184（184 aa）
|
Not recorded | ATP ADENOSINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 6 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 6BSX CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION Deposited 2017-12-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：RHEB VCID 10367
|
Not recorded | MG MAGNESIUM ION × 1 ACT ACETATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 E7S (5,6-dimethyl-1H-benzimidazol-2-yl)methanol × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 8.8；293 K；28% PEG4000, 0.2M SODIUM ACETATE, 0.1M TRIS-HCL, PH 8.8, SITTING DROP, TEMPERATURE 293K
|
Resolution 1.65 Å R-free 0.244 |
| 6BSX CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION Deposited 2017-12-04 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–169（169 aa）
Fragment：RHEB VCID 10367
|
Not recorded | MG MAGNESIUM ION × 1 ACT ACETATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 E7S (5,6-dimethyl-1H-benzimidazol-2-yl)methanol × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 8.8；293 K；28% PEG4000, 0.2M SODIUM ACETATE, 0.1M TRIS-HCL, PH 8.8, SITTING DROP, TEMPERATURE 293K
|
Resolution 1.65 Å R-free 0.244 |
| 6BSX CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION Deposited 2017-12-04 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–169（169 aa）
Fragment：RHEB VCID 10367
|
Not recorded | MG MAGNESIUM ION × 1 ACT ACETATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 E7S (5,6-dimethyl-1H-benzimidazol-2-yl)methanol × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 8.8；293 K；28% PEG4000, 0.2M SODIUM ACETATE, 0.1M TRIS-HCL, PH 8.8, SITTING DROP, TEMPERATURE 293K
|
Resolution 1.65 Å R-free 0.244 |
| 6BSX CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION Deposited 2017-12-04 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
1–169（169 aa）
Fragment：RHEB VCID 10367
|
Not recorded | MG MAGNESIUM ION × 1 ACT ACETATE ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 E7S (5,6-dimethyl-1H-benzimidazol-2-yl)methanol × 1 EDO 1,2-ETHANEDIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 8.8；293 K；28% PEG4000, 0.2M SODIUM ACETATE, 0.1M TRIS-HCL, PH 8.8, SITTING DROP, TEMPERATURE 293K
|
Resolution 1.65 Å R-free 0.244 |
| 6BT0 CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1 Deposited 2017-12-04 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
|
Not recorded | MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；19% PEG 1500, 0.1M Na acetate pH 5.0
|
Resolution 2.60 Å R-free 0.316 |
| 6BT0 CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1 Deposited 2017-12-04 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–169（169 aa）
|
Not recorded | MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 E7V 4-bromo-6-[(3,4-dichlorophenyl)sulfanyl]-1-{[4-(dimethylcarbamoyl)phenyl]methyl}-1H-indole-2-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；19% PEG 1500, 0.1M Na acetate pH 5.0
|
Resolution 2.60 Å R-free 0.316 |
| 6BT0 CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1 Deposited 2017-12-04 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–169（169 aa）
|
Not recorded | MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；19% PEG 1500, 0.1M Na acetate pH 5.0
|
Resolution 2.60 Å R-free 0.316 |
| 6BT0 CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1 Deposited 2017-12-04 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
1–169（169 aa）
|
Not recorded | MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；19% PEG 1500, 0.1M Na acetate pH 5.0
|
Resolution 2.60 Å R-free 0.316 |
| 7BTA Crystal structure of Rheb D60K mutant bound to GDP Deposited 2020-03-31 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：D60K | GDP GUANOSINE-5'-DIPHOSPHATE × 1 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 8；290 K；0.2 M NaH2PO4: 16% PEG 3350
|
Resolution 2.60 Å R-free 0.256 |
| 7BTA Crystal structure of Rheb D60K mutant bound to GDP Deposited 2020-03-31 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：D60K | GDP GUANOSINE-5'-DIPHOSPHATE × 1 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 8；290 K；0.2 M NaH2PO4: 16% PEG 3350
|
Resolution 2.60 Å R-free 0.256 |
| 7BTC Crystal structure of Rheb Y35N mutant bound to GDP Deposited 2020-04-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：Y35N | GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 5.5；290 K；0.10% n-Octyl-beta-D-glucoside: 0.1 M Sodium citrate tribasic, pH 5.5: 22% PEG 3350
|
Resolution 2.10 Å R-free 0.233 |
| 7BTC Crystal structure of Rheb Y35N mutant bound to GDP Deposited 2020-04-01 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：Y35N | GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 5.5；290 K；0.10% n-Octyl-beta-D-glucoside: 0.1 M Sodium citrate tribasic, pH 5.5: 22% PEG 3350
|
Resolution 2.10 Å R-free 0.233 |
| 7BTC Crystal structure of Rheb Y35N mutant bound to GDP Deposited 2020-04-01 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：Y35N | GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 5.5；290 K；0.10% n-Octyl-beta-D-glucoside: 0.1 M Sodium citrate tribasic, pH 5.5: 22% PEG 3350
|
Resolution 2.10 Å R-free 0.233 |
| 7BTC Crystal structure of Rheb Y35N mutant bound to GDP Deposited 2020-04-01 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：Y35N | GDP GUANOSINE-5'-DIPHOSPHATE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 5.5；290 K；0.10% n-Octyl-beta-D-glucoside: 0.1 M Sodium citrate tribasic, pH 5.5: 22% PEG 3350
|
Resolution 2.10 Å R-free 0.233 |
| 7BTD Crystal structure of Rheb Y35N mutant bound to GppNHp Deposited 2020-04-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–169（169 aa）
Fragment：GTPase domain
|
Mutation：Y35N | MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7.5；290 K；0.2 M Ammonium acetate: 0.1 M HEPES, pH 7.5: 25% PEG 3350.
|
Resolution 2.00 Å R-free 0.208 |
| 9ED4 A composite map of mTORC1-Rag-Ragultor-4EBP1 on membrane Deposited 2024-11-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count |
Chain L
1–184（184 aa）
Chain N
1–184（184 aa）
|
Not recorded | GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 2 MG MAGNESIUM ION × 8 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 IHP INOSITOL HEXAKISPHOSPHATE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.23 Å |
| 9ED7 Active state of mTOR on membrane Deposited 2024-11-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain L
1–184（184 aa）
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 MG MAGNESIUM ION × 3 IHP INOSITOL HEXAKISPHOSPHATE × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 9ED8 Intermediate state of mTOR on membrane Deposited 2024-11-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain L
1–184（184 aa）
|
Not recorded | ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 1 IHP INOSITOL HEXAKISPHOSPHATE × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.61 Å |