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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q16572 New Search
11PDB entries
11Biological assembly
14chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
8XTW Structure of human VAChT in complex with acetylcholine Deposited 2024-01-12 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–26（26 aa）
Chain A 27–476（450 aa）
Mutation：S30R,Y39N,F64L,S65T,Q80R,F99S,N105T,Y145F,M153T,V163A,I171V,A206V Mutation：S30R,Y39N,F64L,S65T,Q80R,F99S,N105T,Y145F,M153T,V163A,I171V,A206V ACH ACETYLCHOLINE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8XTX Structure of human VAChT in an apo conformation Deposited 2024-01-12 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–26（26 aa）
Chain A 27–476（450 aa）
Mutation：S30R,Y39N,F64L,S65T,Q80R,F99S,N105T,Y145F,M153T,V163A,I171V,A206V Mutation：S30R,Y39N,F64L,S65T,Q80R,F99S,N105T,Y145F,M153T,V163A,I171V,A206V No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8XTY Structure of human VAChT in complex with vesamicol Deposited 2024-01-12 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–26（26 aa）
Chain A 27–476（450 aa）
Mutation：S30R,Y39N,F64L,S65T,Q80R,F99S,N105T,Y145F,M153T,V163A,I171V,A206V Mutation：S30R,Y39N,F64L,S65T,Q80R,F99S,N105T,Y145F,M153T,V163A,I171V,A206V A1LWL vesamicol × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8ZMR Vesamicol-bound VAChT Deposited 2024-05-23 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 34–524（491 aa）
Mutation：A520E A1LWL vesamicol × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.25
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8ZMS Acetylcholine-bound VAChT Deposited 2024-05-23 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 34–524（491 aa）
Mutation：A520E ACH ACETYLCHOLINE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.25
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
9KKN Cryo-EM structure of human VAChT in complex with ACh Deposited 2024-11-14 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–532（508 aa）
Mutation：M8W,H103I,R107L ACH ACETYLCHOLINE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.72 Å
9KKO Cryo-EM structure of human VAChT in apo state Deposited 2024-11-14 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–532（508 aa）
Mutation：M8W,H103I,R107L No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.25 Å
9KQ5 Cryo-EM structure of human VAChT at protonated state Deposited 2024-11-25 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–532（508 aa）
Mutation：M8W,H103I,R107L No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.21 Å
9KQM Cryo-EM structure of human VAChT in complex with VSM Deposited 2024-11-26 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 25–532（508 aa）
Mutation：M8W,H103I,R107L No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.50 Å
9WJH Spiroindoline-bound human VAChT Deposited 2025-08-31 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 34–524（491 aa）
Not recorded A1EWS (6-bromanylpyridin-3-yl)-[1'-[(~{E})-3-(4-chlorophenyl)prop-2-enyl]-5-fluoranyl-spiro[2~{H}-indole-3,4'-piperidine]-1-yl]methanone × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.25
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9WJI Alkylsulfone-bound human VAChT Deposited 2025-08-31 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 34–524（491 aa）
Not recorded A1EWW 2-(3-ethylsulfonylpyridin-2-yl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridine × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.25
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.