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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q2N0S5 New Search
54PDB entries
54Biological assembly
219chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4TVP Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22 Deposited 2014-06-27 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain B 509–661（153 aa） Fragment：UNP residues 509-661
Chain G 30–505（476 aa） Fragment：UNP residues 30-505
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 SO4 SULFATE ION × 30 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；16% isopropanol, 5.32% PEG1500, 0.2M LiSO4, 0.1M Sodium acetate pH 5.5
Resolution 3.10 Å R-free 0.248
5U7M Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom Deposited 2016-12-12 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 509–661（153 aa） Fragment：UNP residues 509-661
Chain G 30–510（481 aa） Fragment：UNP residues 30-505
Not recorded SO4 SULFATE ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 83G 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；6% ISOPROPANOL, 5.32% PEG1500, 0.2M LISO4, 0.1M SODIUM ACETATE PH 5.5
Resolution 3.02 Å R-free 0.289
5U7O Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom Deposited 2016-12-12 Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 509–661（153 aa） Fragment：UNP residues 509-661
Chain G 30–510（481 aa） Fragment：UNP residues 30-510
Not recorded SO4 SULFATE ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 83J 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；16% ISOPROPANOL, 5.32% PEG1500, 0.2M LISO4, 0.1M SODIUM ACETATE PH 5.5
Resolution 3.03 Å R-free 0.325
6CDE Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 Deposited 2018-02-08 Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count
Chain 2 30–502（473 aa）
Chain C 30–502（473 aa）
Chain c 30–502（473 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 MAN alpha-D-mannopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6CDI Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 Deposited 2018-02-08 Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count
Chain 2 30–502（473 aa）
Chain C 30–502（473 aa）
Chain d 30–502（473 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
6CE0 Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom Deposited 2018-02-09 Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain B 567–661（95 aa）
Mutation：T602C,T602C,T602C,T602C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.4；277.15 K；0.1 Tris (pH 7.4), 0.2 M lithium sulfate, 6% (w/v) polyethylene glycol 4000
Resolution 4.60 Å R-free 0.341
6CM3 BG505 SOSIP in complex with sCD4, 17b, 8ANC195 Deposited 2018-03-02 Assembly 1 Other combination Heteromer；Protein × 21 PDB declaration: 21-meric（21） Consistent with protein count
Chain D 30–508（479 aa）
Chain E 30–508（479 aa）
Chain F 30–508（479 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.54 Å
6CRQ Glutaraldehyde-treated BG505 SOSIP.664 Env in complex with PGV04 Fab Deposited 2018-03-19 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 31–505（475 aa）
Chain B 31–505（475 aa）
Chain F 31–505（475 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；50 mM Tris, 150 mM NaCl, 0.3 mM DDM.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
6DFH BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding Deposited 2018-05-14 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 509–661（153 aa）
Chain E 509–661（153 aa）
Chain F 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE；5 second blot time
Resolution 3.85 Å
6UDA Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664 Deposited 2019-09-19 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain F 508–661（154 aa）
Chain J 508–661（154 aa）
Chain Z 508–661（154 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
6VY2 Cryo-EM structure of M1214_N1 Fab in complex with CH505 TF chimeric SOSIP.664 Env trimer Deposited 2020-02-25 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 508–661（154 aa）
Chain D 508–661（154 aa）
Chain F 508–661（154 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.86 Å
7KLC Crystal structure of M4H2K1 Fab bound to HIV-1 BG505 gp120 core and to 17b Fab Deposited 2020-10-29 Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 43–126（84 aa） Fragment：UNP residues 43-126,194-489,UNP residues 43-126,194-489,UNP residues 43-126,194-489,UNP residues 43-126,194-489
Chain A 194–489（296 aa） Fragment：UNP residues 43-126,194-489,UNP residues 43-126,194-489,UNP residues 43-126,194-489,UNP residues 43-126,194-489
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1M Tris, pH 7, 1.825 M ammonium sulfate, 0.29 M lithium sulfate, 15% ethylene glycol
Resolution 4.30 Å R-free 0.334
7L8E BG505 SOSIP.v5.2(7S) in complex with the polyclonal Fab pAbC-1 from animal Rh.33172 (Wk38 time point) Deposited 2020-12-31 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain B 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain C 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain D 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain E 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain F 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 44 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS buffer prepared from a 10X stock
cryo-EM vitrification conditions Cryogen ETHANE；Blotting time varied between 3 and 7 seconds.
Resolution 4.20 Å
7L8F BG505 SOSIP.v5.2(7S) in complex with the polyclonal Fab pAbC-2 from animal Rh.33172 (Wk38 time point) Deposited 2020-12-31 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain B 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain C 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain D 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain E 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain F 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 49 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS buffer prepared from a 10X stock
cryo-EM vitrification conditions Cryogen ETHANE；Blotting time varied between 3 and 7 seconds.
Resolution 3.66 Å
7L8G BG505 SOSIP.v5.2(7S) in complex with the polyclonal Fab pAbC-3 from animal Rh.33172 (Wk38 time point) Deposited 2020-12-31 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain B 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain C 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain D 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain E 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Chain F 30–661（632 aa） Fragment：GP120 domain, residues 30-661
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 39 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；TBS buffer prepared from a 10X stock
cryo-EM vitrification conditions Cryogen ETHANE；Blotting time varied between 3 and 7 seconds.
Resolution 4.30 Å
7T9T Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with complex glycans Deposited 2021-12-20 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 508–661（154 aa）
Chain F 508–661（154 aa）
Chain J 508–661（154 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot for 2.5 S before plunging
Resolution 3.70 Å
7TCN Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with high-mannose glycans Deposited 2021-12-27 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 508–661（154 aa）
Chain F 508–661（154 aa）
Chain J 508–661（154 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 13 MAN alpha-D-mannopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；BLOT FOR 2.5 S BEFORE PLUNGING
Resolution 4.10 Å
7TCO Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 with high-mannose glycans Deposited 2021-12-27 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 508–661（154 aa）
Chain F 508–661（154 aa）
Chain N 508–661（154 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；BLOT FOR 2.5 S BEFORE PLUNGING
Resolution 4.19 Å
7UGN Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 Deposited 2022-03-25 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 31–503（473 aa）
Chain B 31–503（473 aa）
Chain C 31–503（473 aa）
Chain D 515–661（147 aa）
Chain E 515–661（147 aa）
Chain F 515–661（147 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 MAN alpha-D-mannopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
7UGO Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 Deposited 2022-03-25 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 31–503（473 aa）
Chain B 31–503（473 aa）
Chain C 31–503（473 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 21 MAN alpha-D-mannopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
7UGP Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 Deposited 2022-03-25 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 31–503（473 aa）
Chain B 31–503（473 aa）
Chain C 31–503（473 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 33 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
8C8T cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117 Deposited 2023-01-21 Assembly 1 Other combination Heteromer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain A 33–501（469 aa）
Chain F 33–501（469 aa）
Chain G 33–501（469 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8FYI Structure of HIV-1 BG505 SOSIP-HT1 in complex with one CD4 molecule Deposited 2023-01-26 Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain A 32–505（474 aa）
Chain B 32–505（474 aa）
Chain C 32–505（474 aa）
Mutation：D368R Mutation：D368R NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 35 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8FYJ Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I) Deposited 2023-01-26 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 32–505（474 aa）
Chain B 32–505（474 aa）
Chain C 32–505（474 aa）
Mutation：D368R NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
8TKC CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB Deposited 2023-07-25 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 30–508（479 aa）
Chain D 509–661（153 aa）
Chain E 30–508（479 aa）
Chain F 509–661（153 aa）
Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8TL2 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB Deposited 2023-07-26 Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 30–508（479 aa）
Chain D 509–661（153 aa）
Chain E 30–508（479 aa）
Chain F 509–661（153 aa）
Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8TL3 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB Deposited 2023-07-26 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 30–508（479 aa）
Chain D 509–661（153 aa）
Chain E 30–508（479 aa）
Chain F 509–661（153 aa）
Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8TL4 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-e.01 FAB Deposited 2023-07-26 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 30–508（479 aa）
Chain D 509–661（153 aa）
Chain E 30–508（479 aa）
Chain F 509–661（153 aa）
Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8TL5 CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB Deposited 2023-07-26 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 30–508（479 aa）
Chain D 509–661（153 aa）
Chain E 30–508（479 aa）
Chain F 509–661（153 aa）
Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations Mutation：BG505 DS-SOSIP mutations NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8TNU Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Deposited 2023-08-02 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain E 30–508（479 aa）
Chain F 30–508（479 aa）
Chain G 30–508（479 aa）
Chain X 509–661（153 aa）
Chain Y 509–661（153 aa）
Chain Z 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 37 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.36 Å
8TO7 Cryo-EM structure of HERH-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP Deposited 2023-08-03 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain A 509–661（153 aa）
Chain B 509–661（153 aa）
Chain C 509–661（153 aa）
Chain D 30–508（479 aa）
Chain E 30–508（479 aa）
Chain F 30–508（479 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 45 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.39 Å
8TQ1 HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 Deposited 2023-08-06 Assembly 1 Other combination Heteromer；Protein × 13 PDB declaration: 13-meric（13） Consistent with protein count
Chain B 509–661（153 aa）
Chain F 509–661（153 aa）
Chain K 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 45 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8TTW Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074 Deposited 2023-08-15 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain B 509–661（153 aa）
Chain F 509–661（153 aa）
Chain J 509–661（153 aa）
Mutation：I559P T605C Mutation：I559P T605C Mutation：I559P T605C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 21 83J 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
8ULR Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 05_B08 Fabs Deposited 2023-10-16 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: dodecameric（12） Consistent with protein count
Chain B 509–661（153 aa）
Chain D 509–661（153 aa）
Chain F 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 14 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3s blot, 0 blot force
Resolution 3.30 Å
8ULS Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 01_D03 Fabs Deposited 2023-10-16 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain B 509–661（153 aa）
Chain D 509–661（153 aa）
Chain F 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3s blot, 0 blot force
Resolution 3.20 Å
8ULT Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 Fabs Deposited 2023-10-16 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain B 509–661（153 aa）
Chain D 509–661（153 aa）
Chain F 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 29 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3s blot, 0 blot force
Resolution 3.80 Å
8ULU Cryo-EM structure of the BG505 SOSIPv2 in complex with bNAb 04_A06 and PGDM1400 Fabs Deposited 2023-10-16 Assembly 1 Other combination Heteromer；Protein × 14 PDB declaration: 14-meric（14） Consistent with protein count
Chain B 509–661（153 aa）
Chain D 509–661（153 aa）
Chain F 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3s blot, 0 blot force
Resolution 3.80 Å
9D7O Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 Fab bound Deposited 2024-08-16 Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 9–501（493 aa）
Chain B 502–661（160 aa）
Chain C 9–501（493 aa）
Chain D 502–661（160 aa）
Chain E 9–501（493 aa）
Chain F 502–661（160 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 23 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2
Resolution 3.56 Å
9D8V Cryo-EM structure of the BG505 SOSIPv2 Deposited 2024-08-20 Assembly 1 Other combination Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 32–501（470 aa） Fragment：UNP residues 32-501
Chain B 516–661（146 aa） Fragment：UNP residues 516-661
Chain C 32–501（470 aa） Fragment：UNP residues 32-501
Chain D 516–661（146 aa） Fragment：UNP residues 516-661
Chain E 32–501（470 aa） Fragment：UNP residues 32-501
Chain F 516–661（146 aa） Fragment：UNP residues 516-661
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 29 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE；3s blot, 0 blot force
Resolution 2.90 Å
9D8Y Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with one gp120 rotated, Population 4 Deposited 2024-08-20 Assembly 1 Other combination Heteromer；Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein count
Chain A 32–500（469 aa）
Chain B 32–500（469 aa）
Chain C 32–500（469 aa）
Mutation：T332N, A501C Mutation：T332N, A501C Mutation：T332N, A501C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.06 Å
9D90 Cryo-EM structure of partially open HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-17b Fab and 3-VRC34.01 Fab, Population 1 Deposited 2024-08-20 Assembly 1 Other combination Heteromer；Protein × 21 PDB declaration: 21-meric（21） Consistent with protein count
Chain A 32–500（469 aa）
Chain B 32–500（469 aa）
Chain C 32–500（469 aa）
Chain D 509–657（149 aa）
Chain E 509–657（149 aa）
Chain F 509–657（149 aa）
Mutation：T332N, A501C Mutation：T332N, A501C Mutation：T332N, A501C Mutation：I559P, T605C Mutation：I559P, T605C Mutation：I559P, T605C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.91 Å
9D98 Cryo-EM structure of HIV-1 BG505 SOSIP.664 Env bound to 3-sCD4, 3-VRC34.01 Fab with two gp120 protomers rotated, Population 5 Deposited 2024-08-21 Assembly 1 Other combination Heteromer；Protein × 15 PDB declaration: pentadecameric（15） Consistent with protein count
Chain A 32–500（469 aa）
Chain B 32–500（469 aa）
Chain C 32–500（469 aa）
Chain D 509–661（153 aa）
Chain E 509–661（153 aa）
Chain F 509–661（153 aa）
Mutation：T332N, A501C Mutation：T332N, A501C Mutation：T332N, A501C Mutation：I559P, T605C Mutation：I559P, T605C Mutation：I559P, T605C No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.19 Å
9DMB Rhesus RHA10.01 Fab in complex with HIV-1 Env BG505 DS-SOSIP trimer Deposited 2024-09-12 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain E 509–661（153 aa）
Chain I 509–661（153 aa）
Chain J 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；PBS
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.27 Å
9EHL Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class I Deposited 2024-11-23 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 32–505（474 aa） Fragment：UNP residues 32-505
Chain B 32–505（474 aa） Fragment：UNP residues 32-505
Chain C 32–505（474 aa） Fragment：UNP residues 32-505
Chain D 509–661（153 aa） Fragment：UNP residues 509-661
Chain E 509–661（153 aa） Fragment：UNP residues 509-661
Chain F 509–661（153 aa） Fragment：UNP residues 509-661
Mutation：T326N,A494C Mutation：T326N,A494C Mutation：T326N,A494C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
9EHM Structure of HIV-1 BG505 SOSIP.664 Env trimer in complex with IOMAmin5 and 10-1074 Broadly Neutralizing Antibodies - Class II Deposited 2024-11-23 Assembly 1 Other combination Heteromer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain A 32–505（474 aa） Fragment：UNP residues 32-505
Chain B 32–505（474 aa） Fragment：UNP residues 32-505
Chain C 32–505（474 aa） Fragment：UNP residues 32-505
Chain D 509–661（153 aa） Fragment：UNP residues 509-661
Chain E 509–661（153 aa） Fragment：UNP residues 509-661
Chain F 509–661（153 aa） Fragment：UNP residues 509-661
Mutation：T326N,A494C Mutation：T326N,A494C Mutation：T326N,A494C NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 29 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
9P6E N49P7-FR Fab in complex with BG505 MD39 SOSIP and RM20A3 Fab Deposited 2025-06-18 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: 18-meric（18） Consistent with protein count
Chain A 30–510（481 aa）
Chain C 30–510（481 aa）
Chain E 30–510（481 aa）
Mutation：T105E, M270I, F287L, R303V, A316Y, T330N, N361Q, A498C, E506R, K507R, A509R, V510R Mutation：T105E, M270I, F287L, R303V, A316Y, T330N, N361Q, A498C, E506R, K507R, A509R, V510R Mutation：T105E, M270I, F287L, R303V, A316Y, T330N, N361Q, A498C, E506R, K507R, A509R, V510R NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 33 ELECTRON MICROSCOPY
cryo-EM buffer pH 5.9
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9P6G eN49P7-FRv1-23 Fab in complex with BG505 MD39 SOSIP and RM20A3 Fab Deposited 2025-06-19 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: 18-meric（18） Consistent with protein count
Chain A 30–510（481 aa）
Chain C 30–510（481 aa）
Chain E 30–510（481 aa）
Mutation：T105E, M270I, F287L, R303V, A316Y, T330N, N361Q, A498C, E506R, K507R, A509R, V510R Mutation：T105E, M270I, F287L, R303V, A316Y, T330N, N361Q, A498C, E506R, K507R, A509R, V510R Mutation：T105E, M270I, F287L, R303V, A316Y, T330N, N361Q, A498C, E506R, K507R, A509R, V510R NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 36 ELECTRON MICROSCOPY
cryo-EM buffer pH 5.9
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9PIT HIV-1 bnAb 1-23 in complex with BG505 MD39 SOSIP and RM19R Deposited 2025-07-11 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: 18-meric（18） Consistent with protein count
Chain B 30–510（481 aa）
Chain E 30–510（481 aa）
Chain F 30–510（481 aa）
Mutation：T106E, M271I, F288L, R304V, A319Y, T332N, N363Q, A501C, E509R, K510R, A512R, V513R Mutation：T106E, M271I, F288L, R304V, A319Y, T332N, N363Q, A501C, E509R, K510R, A512R, V513R Mutation：T106E, M271I, F288L, R304V, A319Y, T332N, N363Q, A501C, E509R, K510R, A512R, V513R NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 21 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9PIV HIV-1 bnAb 9-71 in complex with BG505 MD39 SOSIP and RM19R Deposited 2025-07-11 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: 18-meric（18） Consistent with protein count
Chain B 30–510（481 aa）
Chain E 30–510（481 aa）
Chain F 30–510（481 aa）
Mutation：T106E, M271I, F288L, R304V, A319Y, T332N, N363Q, A501C, E509R, K510R, A512R, V513R Mutation：T106E, M271I, F288L, R304V, A319Y, T332N, N363Q, A501C, E509R, K510R, A512R, V513R Mutation：T106E, M271I, F288L, R304V, A319Y, T332N, N363Q, A501C, E509R, K510R, A512R, V513R NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 30 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
9Q09 Cryo-EM structure of PGT121 Fab and Rhesus macaque Ab76 Fab in complex with HIV-1 Env trimer BG505 SOSIP.664 Deposited 2025-08-12 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 509–661（153 aa）
Chain G 30–508（479 aa）
Chain I 30–508（479 aa）
Chain J 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 17 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；1X PBS buffer
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.23 Å
9Q0W Cryo-EM Structure of HIV-1 BG505DS-SOSIP.664 Env Trimer Bound to DFPH-a.01_10R59P_LC Fab Deposited 2025-08-13 Assembly 1 Other combination Heteromer；Protein × 12 PDB declaration: 12-meric（12） Consistent with protein count
Chain B 509–661（153 aa）
Chain D 509–661（153 aa）
Chain F 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
9Q3S Cryo-EM structure of PGT121 Fab and Rhesus macaque Ab4 Fab in complex with HIV-1 Env trimer BG505 SOSIP.664 Deposited 2025-08-19 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 509–661（153 aa）
Chain G 30–508（479 aa）
Chain I 30–508（479 aa）
Chain J 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 21 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å
9Q3X The CryoEM structure of Rhesus macaque 1G3 and PGT121 Fabs in complex with BG505 SOSIP.664 Deposited 2025-08-19 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 509–661（153 aa）
Chain G 30–508（479 aa）
Chain I 30–508（479 aa）
Chain J 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；phosphate buffered saline
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.64 Å
9Y9V THE CRYOEM STRUCTURE OF RHESUS MACAQUE 1A8 AND PGT121 FABS IN COMPLEX WITH BG505 SOSIP.664. Deposited 2025-09-15 Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric（18） Consistent with protein count
Chain A 30–508（479 aa）
Chain B 509–661（153 aa）
Chain C 509–661（153 aa）
Chain G 30–508（479 aa）
Chain I 30–508（479 aa）
Chain J 509–661（153 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.98 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.