Current Protein Identity：Q4E2L0
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 10BL Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex ADP Deposited 2026-01-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
123–474（352 aa）
Fragment：residues 123-474
Chain B
123–474（352 aa）
Fragment：residues 123-474
|
Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) | CL CHLORIDE ION × 3 ADP ADENOSINE-5'-DIPHOSPHATE × 2 MLI MALONATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；Grid Salt Screen, C12: 3.40M Sodium Malonate, pH 5.0. TrcrB.01480.a.WW4.PS38791 at 16.9 mg/mL. 4mM ATP and 4mM MgCl2 added to the protein prior to crystallization but only ADP was bound. several Ser residues displayed electron density consistent with phosphorylation. plate 20528 C12, Puck: PSL-0916, Cryo: 2.5M LiSO4
|
Resolution 2.60 Å R-free 0.265 |
| 10SL Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with Hesperadin Deposited 2026-02-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
123–474（352 aa）
Fragment：residues 123-474
Chain B
123–474（352 aa）
Fragment：residues 123-474
|
Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) | H1N N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE × 2 MLI MALONATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；3.0M Sodium Malonate, pH 5.0. TrcrB.01480.a.WW4.PS38791 at 16.9 mg/mL. Cocrystallization with 4mM ATP and 4mM MgCl2. Crystals were soaked overnight in 10 mM Hespreadin solubilized in 3.0M Malonate, pH 5.0 which displaced the ATP. plate Liu-S-198, Puck: PSL-1705, Cryo: 3.0M Sodium Malonate
|
Resolution 2.72 Å R-free 0.269 |
| 12OB Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with AMP Deposited 2026-04-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
123–474（352 aa）
Fragment：residues 123-474
Chain B
123–474（352 aa）
Fragment：residues 123-474
|
Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) | AMP ADENOSINE MONOPHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；3.0M Sodium Malonate, pH 5.0. TrcrB.01480.a.WW4.PS38791 at 16.9 mg/mL. Cocrystallization with 4mM ATP and 4mM MgCl2. Crystals were soaked overnight in 10 mM AMP solubilized in 3.0M Malonate, pH 5.0 (cryo solution) which displaced the ATP. plate Liu-S-198, Puck: PSL-0201, Cryo: 3.0M Sodium Malonate
|
Resolution 2.83 Å R-free 0.281 |
| 12OC Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with ATP Deposited 2026-04-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
123–474（352 aa）
Fragment：residues 123-474
Chain B
123–474（352 aa）
Fragment：residues 123-474
|
Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) | ATP ADENOSINE-5'-TRIPHOSPHATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；3.0M Sodium Malonate, pH 5.0. TrcrB.01480.a.WW4.PS38791 at 16.9 mg/mL. Cocrystallization with 4mM ATP and 4mM MgCl2. Crystals were soaked overnight in 10 mM ATP solubilized in 3.0M Malonate, pH 5.0 (cryo solution) which displaced the ATP. plate Liu-S-198, Puck: PSL-0203, Cryo: 3.0M Sodium Malonate
|
Resolution 2.68 Å R-free 0.283 |
| 12PL Crystal Structure of serine/threonine-protein kinase (AEK1) from Trypanosoma cruzi in complex with LMS Deposited 2026-04-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
123–474（352 aa）
Fragment：residues 123-474
Chain B
123–474（352 aa）
Fragment：residues 123-474
|
Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：T185I, V227F, N314S Non-standard monomer：Yes (specific site not provided by mmCIF) | LMS [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；3.0M Sodium Malonate, pH 5.0. TrcrB.01480.a.WW4.PS38791 at 16.9 mg/mL. Cocrystallization with 4mM ATP and 4mM MgCl2. Crystals were soaked overnight in 10 mM LMS solubilized in 3.0M Malonate, pH 5.0 (cryo solution) which displaced the ATP. plate Liu-S-198, Puck: PSL-0206, Cryo: 3.0M Sodium Malonate
|
Resolution 2.82 Å R-free 0.279 |