Current Protein Identity：Q6Q1S2
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2IEQ Core Structure of S2 from the Human Coronavirus NL63 Spike Glycoprotein Deposited 2006-09-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
981–1037（57 aa）
Fragment：residues 981-1038, 1242-1283 connected by 10-mer link
Chain A
1242–1283（42 aa）
Fragment：residues 981-1038, 1242-1283 connected by 10-mer link
Chain B
981–1037（57 aa）
Fragment：residues 981-1038, 1242-1283 connected by 10-mer link
Chain B
1242–1283（42 aa）
Fragment：residues 981-1038, 1242-1283 connected by 10-mer link
Chain C
981–1037（57 aa）
Fragment：residues 981-1038, 1242-1283 connected by 10-mer link
Chain C
1242–1283（42 aa）
Fragment：residues 981-1038, 1242-1283 connected by 10-mer link
|
Not recorded | NA SODIUM ION × 3 ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.2；298 K；PEG 400, sodium acetate, Imidazole, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.75 Å R-free 0.240 |
| 3KBH Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor Deposited 2009-10-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain E
481–616（136 aa）
Fragment：residues 481-616
Chain G
481–616（136 aa）
Fragment：residues 481-616
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；285 K；20% PEG 6000, 100 mM Na citrate pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 285K
|
Resolution 3.31 Å R-free 0.300 |
| 3KBH Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor Deposited 2009-10-20 | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain F
481–616（136 aa）
Fragment：residues 481-616
Chain H
481–616（136 aa）
Fragment：residues 481-616
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；285 K；20% PEG 6000, 100 mM Na citrate pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 285K
|
Resolution 3.31 Å R-free 0.300 |
| 5SZS Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy Deposited 2016-08-15 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
16–1291（1276 aa）
Chain B
16–1291（1276 aa）
Chain C
16–1291（1276 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 21 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 7FC3 structure of NL63 receptor-binding domain complexed with horse ACE2 Deposited 2021-07-13 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
481–611（131 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；1.8M Ammonium sulfate, 0.1M BIS-TRIS pH6.5, 2% v/v polyethylene glycol monomethylether 550
|
Resolution 3.19 Å R-free 0.283 |
| 7KIP A 3.4 Angstrom cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles Deposited 2020-10-24 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1356（1356 aa）
Chain B
1–1356（1356 aa）
Chain C
1–1356（1356 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 24 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8；20 mM Tris, pH 8.0, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.39 Å |
| 8FR7 A hinge glycan regulates spike bending and impacts coronavirus infectivity Deposited 2023-01-06 | Assembly 1 Other combination Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1356（1356 aa）
Chain B
1–1356（1356 aa）
Chain C
1–1356（1356 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8；20 mM Tris, pH 8.0, 120 mM NaCl, 1 mM EDTA
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.39 Å |
| 9OPQ TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD Deposited 2025-05-19 | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
867–877（11 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9Z3J HCoV-NL63 S2' peptide bound to TMPRSS2 S441A (complexed with the H1H7 Fab and an anti-kappa-nanobody) Deposited 2025-11-06 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
866–880（15 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |