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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q7L0J3 New Search
18PDB entries
18Biological assembly
22chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
4V11 Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84 Deposited 2014-09-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 81–90（10 aa） Fragment：UNP RESIDUES 81-90
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 3 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；0.1 M HEPES PH 7.5, 18 % PEG 3350, 0.05 M CACL2
Resolution 1.95 Å R-free 0.196
8JLC Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam Deposited 2023-06-02 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–742（741 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 UKX (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8JLE Cryo-EM structure of SV2A LD4 in complex with BoNT/A2 Hc in the SV2A-levetiracetam-BoNT/A2 Hc complex Deposited 2023-06-02 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 480–587（108 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.82 Å
8JLF Cryo-EM structure of SV2A in complex with BoNT/A2 Hc Deposited 2023-06-02 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–742（741 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å
8JLG Cryo-EM structure of SV2A in complex with BoNT/A2 Hc Deposited 2023-06-02 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 480–590（111 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.87 Å
8JLH Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam Deposited 2023-06-02 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–742（741 aa）
Chain C 2–742（741 aa）
Not recorded UKX (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8JLI Cryo-EM structure of SV2A dimer in complex levetiracetam Deposited 2023-06-02 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–742（741 aa）
Chain B 2–742（741 aa）
Not recorded UKX (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.38 Å
8JS8 Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam Deposited 2023-06-19 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–742（741 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 UKX (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Hepes (pH7.5), 150 mM NaCl, 0.001% LMNG, 0.0002% cholesterol hemisuccinate
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8JS9 Cryo-EM structure of SV2A in complex with BoNT/A2 Hc Deposited 2023-06-19 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–742（741 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å
8K77 Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam Deposited 2023-07-26 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–742（741 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 VLX (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.11 Å
8UO9 Structure of synaptic vesicle protein 2A in complex with a nanobody Deposited 2023-10-19 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 64–742（679 aa）
Not recorded X49 (4S)-1-{[(4S)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(4,4,4-trifluorobutyl)pyrrolidin-2-one × 1 Y01 CHOLESTEROL HEMISUCCINATE × 1 PS1 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE] × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.30 Å
8UOA Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody Deposited 2023-10-19 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 64–742（679 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8；150 mM NaCl, 20 mM Tris pH 8.0, 0.02 mM LMNG, 0.020 mM CHS, 0.050mM GDN, and 1 micromolar of UCB-2500
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.80 Å
8YF0 Cryo-EM structure of human SV2A Deposited 2024-02-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–734（734 aa）
Chain C 1–734（734 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.49 Å
8YF1 Cryo-EM structure of human SV2A in complex with Brivaracetam Deposited 2024-02-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–734（734 aa）
Chain B 1–734（734 aa）
Not recorded VLX (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.38 Å
9NTC Structure of Synaptic Vesicle Protein 2A Bound to Brivaracetam and UCB1244283 Deposited 2025-03-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 64–742（679 aa）
Not recorded A1B1J (3R)-4-(3,5-dimethylphenyl)-N-(2-methoxyphenyl)-3-methylbutanamide × 1 VLX (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide × 1 CLR CHOLESTEROL × 1 A1B1I (3S)-4-(3,5-dimethylphenyl)-N-(2-methoxyphenyl)-3-methylbutanamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.05 Å
9PC9 Structure of Synaptic Vesicle Protein 2A Bound to UCB7361 Deposited 2025-06-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–742（742 aa）
Not recorded A1CHN (4S)-1-{[(4S)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(3,3,3-trifluoropropyl)pyrrolidin-2-one × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.91 Å
9PCB Structure of Synaptic Vesicle Protein 2A Bound to UCB-J Deposited 2025-06-27 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 64–742（679 aa）
Not recorded A1CCA (4R)-1-[(3-methylpyridin-4-yl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.42 Å
9PRS Cryo-EM structure of human SV2A in complex with Levetiracetam and UCB1244283 Deposited 2025-07-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 139–742（604 aa）
Not recorded UKX (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide × 1 A1B1J (3R)-4-(3,5-dimethylphenyl)-N-(2-methoxyphenyl)-3-methylbutanamide × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.03 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.