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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q7Z434 New Search
9PDB entries
12Biological assembly
74chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2MS7 High-resolution solid-state NMR structure of the helical signal transduction filament MAVS CARD Deposited 2014-07-25 Assembly 1 Protein homooligomer Homooligomer；Protein × 21 PDB declaration: 21-meric（21） Consistent with protein count
Chain A 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain B 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain C 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain D 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain E 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain F 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain G 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain H 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain I 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain J 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain K 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain L 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain M 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain N 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain O 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain P 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain Q 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain R 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain S 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain T 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Chain U 1–100（100 aa） Fragment：UNP RESIDUES 1-100
Not recorded No recorded non-water small molecule SOLID-STATE NMR
NMR measurement conditions pH 7；278 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition 20 mM [U-99% 13C; U-99% 15N] MAVS CARD-1, H2O | H2O
NMR sample composition 20 mM [1-13C]-Glc U-15N MAVS CARD-2, H2O | H2O
NMR sample composition 20 mM [2-13C]-Glc U-15N MAVS CARD-3, H2O | H2O
NMR sample composition 20 mM [1/2-13C]-Glc(mixed) U15N MAVS CARD-4, H2O | H2O
NMR sample composition 20 mM [U-99% 13C; U-99% 15N] 1:6(Unlabeled) Diluted sample MAVS CARD-5, H2O | H2O
NMR sample composition 20 mM U15N mixed with U13C labeled sample MAVS CARD-6, H2O | H2O
Resolution not provided
2MS8 Solution NMR structure of MAVS CARD Deposited 2014-07-25 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–100（100 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 3；298 K；Ionic strength (raw mmCIF value) 50；Pressure ambient
NMR sample composition 300 uM [U-99% 13C; U-99% 15N] MAVS CARD-1, 93% H2O/7% D2O | 93% H2O/7% D2O
Resolution not provided
2VGQ Crystal Structure of Human IPS-1 CARD Deposited 2007-11-15 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–93（93 aa） Fragment：MMBP RESIDUES 27-392, CARD DOMAIN RESIDUES 3-93,MMBP RESIDUES 27-392, CARD DOMAIN RESIDUES 3-93
Not recorded SO4 SULFATE ION × 5 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.220
3J6C Cryo-EM structure of MAVS CARD filament Deposited 2014-02-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count
Chain A 3–93（91 aa） Fragment：caspase activation recruitment domain (UNP residues 3-93)
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT；pH 7.5；20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT
cryo-EM vitrification conditions Cryogen ETHANE；Plunged into liquid ethane (FEI VITROBOT MARK III)
Resolution 9.60 Å
3J6C Cryo-EM structure of MAVS CARD filament Deposited 2014-02-04 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 3–93（91 aa） Fragment：caspase activation recruitment domain (UNP residues 3-93)
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT；pH 7.5；20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT
cryo-EM vitrification conditions Cryogen ETHANE；Plunged into liquid ethane (FEI VITROBOT MARK III)
Resolution 9.60 Å
3J6C Cryo-EM structure of MAVS CARD filament Deposited 2014-02-04 Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 3–93（91 aa） Fragment：caspase activation recruitment domain (UNP residues 3-93)
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT；pH 7.5；20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT
cryo-EM vitrification conditions Cryogen ETHANE；Plunged into liquid ethane (FEI VITROBOT MARK III)
Resolution 9.60 Å
3J6J 3.6 Angstrom resolution MAVS filament generated from helical reconstruction Deposited 2014-03-13 Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain B 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain C 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain D 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain E 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain G 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain I 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Chain L 1–97（97 aa） Fragment：N-terminal CARD domain (UNP residues 1-97)
Mutation：P2A Mutation：P2A Mutation：P2A Mutation：P2A Mutation：P2A Mutation：P2A Mutation：P2A Mutation：P2A No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer 20 mM Tris, 150 mM NaCl；pH 7.5；20 mM Tris, 150 mM NaCl
cryo-EM vitrification conditions Cryogen NITROGEN；Plunged in liquid nitrogen (FEI VITROBOT MARK I)
Resolution 3.64 Å R-free 0.276
4P4H Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain Deposited 2014-03-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 21 PDB declaration: 21-meric（21） Consistent with protein count
Chain I 1–99（99 aa）
Chain J 1–99（99 aa）
Chain K 1–99（99 aa）
Chain L 1–99（99 aa）
Chain M 1–99（99 aa）
Chain N 1–99（99 aa）
Chain O 1–99（99 aa）
Chain P 1–99（99 aa）
Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；Tri-Li Citrate, PEG 3350, Cr(III) Cl3
Resolution 3.40 Å R-free 0.240
4Z8M Crystal structure of the MAVS-TRAF6 complex Deposited 2015-04-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 450–468（19 aa） Fragment：UNP residues 450-468
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；6% (v/v) Tacsimate pH 6.0, 0.1 M MES pH 6.0, and 25% (w/v) polyethylene glycol 4000
Resolution 2.95 Å R-free 0.238
4Z8M Crystal structure of the MAVS-TRAF6 complex Deposited 2015-04-09 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 450–468（19 aa） Fragment：UNP residues 450-468
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；6% (v/v) Tacsimate pH 6.0, 0.1 M MES pH 6.0, and 25% (w/v) polyethylene glycol 4000
Resolution 2.95 Å R-free 0.238
7DNI MDA5 CARDs-MAVS CARD polyUb complex Deposited 2020-12-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain M 1–97（97 aa）
Chain N 1–97（97 aa）
Chain O 1–97（97 aa）
Chain P 1–97（97 aa）
Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K Mutation：D23K, E26K, E80K No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
Resolution 3.20 Å
8WKW Structure of MAVS-CARD Filament Deposited 2023-09-28 Assembly 1 Protein homooligomer Homooligomer；Protein × 26 PDB declaration: 26-meric（26） Consistent with protein count
Chain A 1–97（97 aa）
Chain B 1–97（97 aa）
Chain C 1–97（97 aa）
Chain D 1–97（97 aa）
Chain E 1–97（97 aa）
Chain F 1–97（97 aa）
Chain G 1–97（97 aa）
Chain H 1–97（97 aa）
Chain I 1–97（97 aa）
Chain J 1–97（97 aa）
Chain K 1–97（97 aa）
Chain L 1–97（97 aa）
Chain M 1–97（97 aa）
Chain N 1–97（97 aa）
Chain O 1–97（97 aa）
Chain P 1–97（97 aa）
Chain Q 1–97（97 aa）
Chain R 1–97（97 aa）
Chain S 1–97（97 aa）
Chain T 1–97（97 aa）
Chain U 1–97（97 aa）
Chain V 1–97（97 aa）
Chain W 1–97（97 aa）
Chain X 1–97（97 aa）
Chain Y 1–97（97 aa）
Chain Z 1–97（97 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.21 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.