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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q86TI2 New Search
14PDB entries
24Biological assembly
48chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
6EOQ DPP9 - Apo Deposited 2017-10-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–863（863 aa）
Chain C 1–863（863 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；10%PEG 8000, 25% Glycerol, 0.16M Calcium Acetate, 0.08M Caodilate pH6.25,
Resolution 3.00 Å R-free 0.334
6EOQ DPP9 - Apo Deposited 2017-10-10 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；10%PEG 8000, 25% Glycerol, 0.16M Calcium Acetate, 0.08M Caodilate pH6.25,
Resolution 3.00 Å R-free 0.334
6EOR DPP9 - 1G244 Deposited 2017-10-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–863（863 aa）
Chain B 1–863（863 aa）
Not recorded 9XH (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；10% PEG 8000, 25% Glycerol, 0.16M Calcium Acetate, 0.08M Cacodilate pH 6.25
Resolution 2.90 Å R-free 0.332
6EOR DPP9 - 1G244 Deposited 2017-10-10 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded 9XH (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；10% PEG 8000, 25% Glycerol, 0.16M Calcium Acetate, 0.08M Cacodilate pH 6.25
Resolution 2.90 Å R-free 0.332
6QZV DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2 Deposited 2019-03-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–892（892 aa）
Chain B 1–892（892 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.25；293 K；20 mg/ml of protein, 10% PEG 8000, 25% glycerol, 0.16 M calcium acetate, 0.08 M cacodilate pH 6.25. Drops are set in a 1:1 ratio.
Resolution 3.00 Å R-free 0.345
6QZV DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2 Deposited 2019-03-12 Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain C 1–892（892 aa）
Chain D 1–892（892 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.25；293 K；20 mg/ml of protein, 10% PEG 8000, 25% glycerol, 0.16 M calcium acetate, 0.08 M cacodilate pH 6.25. Drops are set in a 1:1 ratio.
Resolution 3.00 Å R-free 0.345
6X6A Cryo-EM structure of NLRP1-DPP9 complex Deposited 2020-05-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris pH 7.5, 150 mM NaCl, 1 mM TCEP
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
6X6C Cryo-EM structure of NLRP1-DPP9-VbP complex Deposited 2020-05-27 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded GK2 [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM Tris pH 7.5, 150 mM NaCl, 1 mM TCEP
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
7A3F Crystal structure of apo DPP9 Deposited 2020-08-18 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–892（892 aa）
Chain B 1–892（892 aa）
Not recorded PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.08 M Na-Cacodilate pH 5.25, 0.16 M Ca-Acetate, 30 % Glycerol, 10 % PEG 8K
Resolution 2.90 Å R-free 0.290
7A3F Crystal structure of apo DPP9 Deposited 2020-08-18 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–892（892 aa）
Chain D 1–892（892 aa）
Not recorded PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.08 M Na-Cacodilate pH 5.25, 0.16 M Ca-Acetate, 30 % Glycerol, 10 % PEG 8K
Resolution 2.90 Å R-free 0.290
7JKQ Human DPP9-CARD8 complex Deposited 2020-07-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25mM HEPES, pH 7.5, 150 mM NaCl, 1 mM TCEP
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7JN7 Human DPP9-CARD8 complex Deposited 2020-08-04 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded GK2 [(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM HEPES, pH 7.5, 150 mM NaCl, 1 mM TCEP
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7SVL DPP9 IN COMPLEX WITH LIGAND ICeD-2 Deposited 2021-11-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–863（863 aa）
Chain B 1–863（863 aa）
Not recorded D06 (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 8000 25% Glycerol 0.16 M Calcium Acetate 0.08 M Cacodilate pH 6.25
Resolution 2.46 Å R-free 0.341
7SVL DPP9 IN COMPLEX WITH LIGAND ICeD-2 Deposited 2021-11-19 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded D06 (2S)-2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[(1r,4S)-4-(pyrrolidin-1-yl)cyclohexyl]ethan-1-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 8000 25% Glycerol 0.16 M Calcium Acetate 0.08 M Cacodilate pH 6.25
Resolution 2.46 Å R-free 0.341
7SVN DPP9 IN COMPLEX WITH LIGAND ICeD-1 Deposited 2021-11-19 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–863（863 aa）
Chain B 1–863（863 aa）
Not recorded CW8 (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 8000 25% glycerol 0.16 M calcium acetate 0.08 M cacodilate pH 6.25
Resolution 2.78 Å R-free 0.349
7SVN DPP9 IN COMPLEX WITH LIGAND ICeD-1 Deposited 2021-11-19 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–863（863 aa）
Chain D 1–863（863 aa）
Not recorded CW8 (2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；10% PEG 8000 25% glycerol 0.16 M calcium acetate 0.08 M cacodilate pH 6.25
Resolution 2.78 Å R-free 0.349
7ZXS Crystal structure of DPP9 in complex with a 4-oxo-b-lactam based inhibitor, A295 Deposited 2022-05-22 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–863（844 aa） Fragment：extcolor{red}{>FRAGMENT<}
Chain C 20–863（844 aa） Fragment：extcolor{red}{>FRAGMENT<}
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) KBO 2-ethyl-2-methanoyl-~{N}-[3-[[4-(quinolin-8-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide × 2 EDO 1,2-ETHANEDIOL × 17 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；The crystal is grown in a condition containing PEG 2K MME buffered by Tris pH 7
Resolution 1.81 Å R-free 0.203
7ZXS Crystal structure of DPP9 in complex with a 4-oxo-b-lactam based inhibitor, A295 Deposited 2022-05-22 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 20–863（844 aa）
Chain D 20–863（844 aa）
Not recorded KBO 2-ethyl-2-methanoyl-~{N}-[3-[[4-(quinolin-8-ylmethyl)piperazin-1-yl]methyl]phenyl]butanamide × 2 EDO 1,2-ETHANEDIOL × 24 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；The crystal is grown in a condition containing PEG 2K MME buffered by Tris pH 7
Resolution 1.81 Å R-free 0.203
9GOC Crystal structure of DPP9 Ser730Ala in complex with sulphostin. Deposited 2024-09-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–863（844 aa）
Chain B 20–863（844 aa）
Not recorded A1INE Sulphostin × 2 EDO 1,2-ETHANEDIOL × 28 PEG DI(HYDROXYETHYL)ETHER × 2 PG5 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；PEG2000 MME 20% (w/v), 0.1 M Tris pH 6.75
Resolution 1.89 Å R-free 0.199
9GOC Crystal structure of DPP9 Ser730Ala in complex with sulphostin. Deposited 2024-09-05 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 20–863（844 aa）
Chain D 20–863（844 aa）
Not recorded A1INE Sulphostin × 2 EDO 1,2-ETHANEDIOL × 19 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；PEG2000 MME 20% (w/v), 0.1 M Tris pH 6.75
Resolution 1.89 Å R-free 0.199
9GOD Crystal structure of DPP9 in complex with N-phosphono-(S)-3-aminopiperidine-2-one-based inhibitor Deposited 2024-09-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–863（844 aa）
Chain D 20–863（844 aa）
Not recorded A1INH ethoxy-[2-(4-pentylphenyl)sulfanylethyl]phosphinous acid × 2 EDO 1,2-ETHANEDIOL × 12 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；18.0% w/v PEG 2K MME; 0.1 M Tris pH 7.25
Resolution 2.49 Å R-free 0.219
9GOD Crystal structure of DPP9 in complex with N-phosphono-(S)-3-aminopiperidine-2-one-based inhibitor Deposited 2024-09-05 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 20–863（844 aa）
Chain C 20–863（844 aa）
Not recorded A1INH ethoxy-[2-(4-pentylphenyl)sulfanylethyl]phosphinous acid × 2 EDO 1,2-ETHANEDIOL × 23 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；18.0% w/v PEG 2K MME; 0.1 M Tris pH 7.25
Resolution 2.49 Å R-free 0.219
9GON Crystal structure of DPP9 in complex with sulphostin Deposited 2024-09-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 20–863（844 aa）
Chain B 20–863（844 aa）
Not recorded A1INF azanyl-oxidanylidene-(sulfoamino)phosphanium × 2 PEG DI(HYDROXYETHYL)ETHER × 3 EDO 1,2-ETHANEDIOL × 37 CL CHLORIDE ION × 7 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20% (w/v) PEG 2000 MME, 0.1M Tris pH 6.75
Resolution 1.89 Å R-free 0.206
9GON Crystal structure of DPP9 in complex with sulphostin Deposited 2024-09-05 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 20–863（844 aa）
Chain D 20–863（844 aa）
Not recorded A1INF azanyl-oxidanylidene-(sulfoamino)phosphanium × 2 PEG DI(HYDROXYETHYL)ETHER × 1 EDO 1,2-ETHANEDIOL × 34 CL CHLORIDE ION × 5 NA SODIUM ION × 3 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；20% (w/v) PEG 2000 MME, 0.1M Tris pH 6.75
Resolution 1.89 Å R-free 0.206

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.