Current Protein Identity：Q8NBP7
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 10SB PCSK9 in complex with cyclic peptide 21 Deposited 2026-02-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.83 Å R-free 0.238 |
| 2P4E Crystal Structure of PCSK9 Deposited 2007-03-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain P
1–692（692 aa）
|
Not recorded | HG MERCURY (II) ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；25% PEG 1500, 50 mM Tris-HCl buffer, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.98 Å R-free 0.250 |
| 2P4E Crystal Structure of PCSK9 Deposited 2007-03-12 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–692（692 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；25% PEG 1500, 50 mM Tris-HCl buffer, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.98 Å R-free 0.250 |
| 2P4E Crystal Structure of PCSK9 Deposited 2007-03-12 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–692（692 aa）
Chain P
1–692（692 aa）
|
Not recorded | HG MERCURY (II) ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；300 K；25% PEG 1500, 50 mM Tris-HCl buffer, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
|
Resolution 1.98 Å R-free 0.250 |
| 2QTW The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain Deposited 2007-08-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
29–152（124 aa）
Fragment：UNP residues 29-152
Chain B
153–692（540 aa）
Fragment：UNP residues 153-692
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 10.5；298 K；20% PEG6000, 0.2M sodium chloride, pH 10.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K, pH 10.50
|
Resolution 1.90 Å R-free 0.239 |
| 2W2M WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR Deposited 2008-11-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–451（299 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 153-451
Chain P
53–152（100 aa）
Fragment：PROPEPTIDE, RESIDUES 53-152
|
Not recorded | CA CALCIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (V/V) 2-PROPANOL, 20% (W/V) PEG 4000
|
Resolution 2.40 Å R-free 0.254 |
| 2W2N WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR Deposited 2008-11-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–451（299 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 153-451
Chain P
53–152（100 aa）
Fragment：PRODOMAIN, RESIDUES 53-152
|
Not recorded | CA CALCIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (W/V) PEG 8000, 8% (V/V) ETHYLENE GLYCOL.
|
Resolution 2.30 Å R-free 0.254 |
| 2W2O PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR Deposited 2008-11-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–451（299 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 153-451
Chain P
53–152（100 aa）
Fragment：PROPEPTIDE, RESIDUES 53-152
|
Mutation：YES | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (W/V) PEG 8000 AND 8% (V/V) ETHYLENE GLYCOL
|
Resolution 2.62 Å R-free 0.263 |
| 2W2P PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR Deposited 2008-11-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–451（299 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 153-451
Chain P
53–152（100 aa）
Fragment：PRODOMAIN, RESIDUES 53-152
|
Mutation：YES | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (W/V) PEG 8000 AND 8% (V/V) ETHYLENE GLYCOL
|
Resolution 2.62 Å R-free 0.270 |
| 2W2Q PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR Deposited 2008-11-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–451（299 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 153-451
Chain P
53–152（100 aa）
Fragment：PROPEPTIDE, RESIDUES 53-152
|
Mutation：YES | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；0.1M HEPES PH 7.5, 10% (W/V) PEG 8000 AND 8% (V/V) ETHYLENE GLYCOL
|
Resolution 2.33 Å R-free 0.253 |
| 2XTJ The crystal structure of PCSK9 in complex with 1D05 Fab Deposited 2010-10-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
153–451（299 aa）
Fragment：CATALYTIC DOMAIN, RESIDUES 153-451
Chain P
53–152（100 aa）
Fragment：PRODOMAIN, RESIDUES 53-152
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；CRYSTALLIZATION EXPERIMENTS WERE PERFORMED AT ROOM TEMPERATURE BY THE HANGING-DROP AND SITTING-DROP METHODS. THIN PLATE-LIKE CRYSTALS WERE OBTAINED IN 100 MM NA CITRATE PH 6.5, 13% PEG 6000. FOR DATA COLLECTION CRYSTALS WERE TRANSFERRED TO A STABILIZING SOLUTION (20 MM TRIS PH 8.0, 50 MM NACITRATE PH 6.5, 100 MM NACL, 5% GLYCEROL, 1 MM TCEP, 1 MICROM CACL2, 25% PEG6000), THEN TRANSFERRED FOR 2 MIN TO A CRYOPROTECTANT SOLUTION (20 MM TRIS PH 8.0, 50 MM NACITRATE PH 6.5, 100 MM NACL, 20% GLYCEROL, 1 MM TCEP, 1 MICROM CACL2, 35% PEG6000) AND FINALLY PLACED DIRECTLY INTO LIQUID NITROGEN.
|
Resolution 2.70 Å R-free 0.259 |
| 3BPS PCSK9:EGF-A complex Deposited 2007-12-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–692（540 aa）
Fragment：Catalytic domain, UNP residues 153-692
Chain P
53–152（100 aa）
Fragment：Prodomain, UNP residues 53-152
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.8；294 K；0.3M (NH4)H2PO4, pH 4.8, VAPOR DIFFUSION, SITTING DROP, temperature 294K, pH 4.80
|
Resolution 2.41 Å R-free 0.240 |
| 3GCW PCSK9:EGFA(H306Y) Deposited 2009-02-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–692（540 aa）
Chain P
53–152（100 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；294 K；0.3M (NH4)H2PO4, pH 7.4, VAPOR DIFFUSION, SITTING DROP, temperature 294K
|
Resolution 2.70 Å R-free 0.278 |
| 3GCX PCSK9:EGFA (pH 7.4) Deposited 2009-02-22 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–692（540 aa）
Chain P
53–152（100 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；294 K；0.3M (NH4)H2PO4, pH 7.4, VAPOR DIFFUSION, SITTING DROP, temperature 294K
|
Resolution 2.70 Å R-free 0.261 |
| 3H42 Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody Deposited 2009-04-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
31–152（122 aa）
Fragment：UNP residues 31-152
Chain B
153–692（540 aa）
Fragment：UNP residues 153-692
|
Mutation：N533A | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.3；293 K；0.1 M Tris-HCl, 0.2 M Sodium acetate, 10-15% PEG 4000, 3-6% Dextran sodium salt (Mr 5000), pH 8.3, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.209 |
| 3M0C The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor Deposited 2010-03-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
29–152（124 aa）
Fragment：PCSK9
Chain B
153–692（540 aa）
Fragment：PCSK9
|
Mutation：D374Y | CA CALCIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；297 K；1.4 M Ammonium phosphate, 0.2M sodium chloride in 0.1M Imidazole buffer, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 297K
|
Resolution 7.01 Å R-free 0.362 |
| 3P5B The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation Deposited 2010-10-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–692（540 aa）
Chain P
61–152（92 aa）
|
Not recorded | CA CALCIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；291 K；0.1 M sodium cacodylate pH 7.0, 1.7 M sodium acetate, 300 mM NaCl, 5% ethanol, VAPOR DIFFUSION, temperature 291K
|
Resolution 3.30 Å R-free 0.298 |
| 3P5C The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation Deposited 2010-10-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
153–692（540 aa）
Chain P
61–152（92 aa）
|
Not recorded | CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7；291 K；0.1M imidazole, 0.7M sodium acetate pH 7.0, VAPOR DIFFUSION, temperature 291K
|
Resolution 4.20 Å R-free 0.348 |
| 3SQO PCSK9 J16 Fab complex Deposited 2011-07-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
153–692（540 aa）
Chain P
31–152（122 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；298 K；7% PEG 10000, 100 mM Hepes pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.70 Å R-free 0.283 |
| 4K8R An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo Deposited 2013-04-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
61–152（92 aa）
Fragment：unp residues 61-152
Chain B
153–692（540 aa）
Fragment：unp residues 153-692
|
Mutation：V474I, G670E | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.5 M lithium sulfate, 0.1 M disodium malonate, 11.5 % PEG 8K , pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.22 Å R-free 0.226 |
| 4NE9 PCSK9 in complex with LDLR peptide Deposited 2013-10-28 | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
153–692（540 aa）
Fragment：UNP residues 153-692
Chain P
1–152（152 aa）
Fragment：UNP residues 1-152
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；299 K；pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 299K
|
Resolution 2.60 Å R-free 0.211 |
| 4NE9 PCSK9 in complex with LDLR peptide Deposited 2013-10-28 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
153–692（540 aa）
Fragment：UNP residues 153-692
Chain C
1–152（152 aa）
Fragment：UNP residues 1-152
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；299 K；pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 299K
|
Resolution 2.60 Å R-free 0.211 |
| 4NMX PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8 Deposited 2013-11-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Fragment：propeptide (UNP residues 31-152)
Chain B
153–452（300 aa）
Fragment：catalytic domain (UNP residues 153-452)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；0.1 M lithium chloride, 10% w/v PEG6000, 0.05 M Tris, pH 8, VAPOR DIFFUSION, SITTING DROP, temperature 292K
|
Resolution 1.85 Å R-free 0.222 |
| 4OV6 Crystal structure of PCSK9(53-451) with Adnectin Deposited 2014-02-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
60–152（93 aa）
Fragment：prodomain (UNP residues 60-152)
Chain B
153–446（294 aa）
Fragment：catalytic domain (UNP residues 153-446)
|
Not recorded | EDO 1,2-ETHANEDIOL × 3 PG4 TETRAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；296 K；22% v/v PEG200, 1% v/v ethylene glycol, 0.1 M MES pH 6.5, crystals harvested next day, cryo-protectant: 30% v/v PEG200, VAPOR DIFFUSION, HANGING DROP, temperature 296K
|
Resolution 2.69 Å R-free 0.231 |
| 4OV6 Crystal structure of PCSK9(53-451) with Adnectin Deposited 2014-02-20 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
60–152（93 aa）
Fragment：prodomain (UNP residues 60-152)
Chain E
153–446（294 aa）
Fragment：catalytic domain (UNP residues 153-446)
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 PG4 TETRAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；296 K；22% v/v PEG200, 1% v/v ethylene glycol, 0.1 M MES pH 6.5, crystals harvested next day, cryo-protectant: 30% v/v PEG200, VAPOR DIFFUSION, HANGING DROP, temperature 296K
|
Resolution 2.69 Å R-free 0.231 |
| 5OCA PCSK9:Fab Complex with Dextran Sulfate Deposited 2017-06-30 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–692（540 aa）
|
Not recorded | NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.3；293 K；0.1 M Tris-HCl, 0.2 M Sodium acetate, 10-15% PEG 4000, 3-6% Dextran sodium salt (Mr 5000), pH 8.3, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.195 |
| 5VL7 PCSK9 complex with Fab33 Deposited 2017-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
Fragment：catalytic and cysteine-rich domains, residues 153-692
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；292 K；potassium sodium phosphate
|
Resolution 3.50 Å R-free 0.245 |
| 5VLA Short PCSK9 delta-P' complex with Fusion2 peptide Deposited 2017-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–452（452 aa）
Fragment：residues 1-452
|
Mutation：R165S | CA CALCIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；calcium acetate, PEG 6000
|
Resolution 2.40 Å R-free 0.267 |
| 5VLH Short PCSK9 delta-P' complex with peptide Pep1 Deposited 2017-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–452（452 aa）
Fragment：residues 1-452
|
Mutation：R165S | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；calcium acetate, PEG 6000
|
Resolution 2.86 Å R-free 0.253 |
| 5VLK Short PCSK9 delta-P' complex with shrunken peptide bearing homo-Arginine Deposited 2017-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–452（452 aa）
Fragment：residues 1-452
|
Mutation：R165S | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；calcium acetate, PEG 6000
|
Resolution 2.20 Å R-free 0.237 |
| 5VLL Short PCSK9 delta-P' complex with peptide Pep3 Deposited 2017-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–452（452 aa）
Fragment：residues 1-452
|
Mutation：R165S | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；292 K；calcium acetate, PEG 6000
|
Resolution 2.37 Å R-free 0.244 |
| 5VLP PCSK9 complex with LDLR antagonist peptide and Fab7G7 Deposited 2017-04-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–692（692 aa）
|
Not recorded | NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；ammonium acetate, 1,8diaminooctane
|
Resolution 2.90 Å R-free 0.209 |
| 6E4Y Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9, unmodified Deposited 2018-07-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain P
32–53（22 aa）
Fragment：UNP residues 32-53
|
Not recorded | ZN ZINC ION × 4 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；15% w/v PEG8000, 0.2 M zinc acetate, 0.1 M sodium cacodylate, pH 6.5
|
Resolution 2.24 Å R-free 0.255 |
| 6E4Z Anti-PCSK9 fab 6E2 bound to the modified N-terminal peptide from PCSK9 Deposited 2018-07-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain P
32–53（22 aa）
Fragment：UNP residues 32-53
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 5 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；15% w/v PEG8000, 0.2 M zinc acetate, 0.1 M sodium cacodylate, pH 6.5
|
Resolution 2.20 Å R-free 0.236 |
| 6MV5 Anti-PCSK9 fab 6E2 bound to the N-terminal peptide from PCSK9 (E32K) Deposited 2018-10-24 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain P
32–53（22 aa）
Fragment：N-terminal peptide (UNP residues 32-53)
|
Mutation：E32K Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 CL CHLORIDE ION × 1 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；15% PEG8000, 0.2 M zinc acetate, 0.1 M sodium cacodylate, pH 6.5
|
Resolution 2.10 Å R-free 0.238 |
| 6OLZ Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA Deposited 2019-04-17 | Assembly 1 Protein–RNA Heteromer；Protein × 76 PDB declaration: 82-meric（82） Consistent with all polymers |
Chain A
9–34（26 aa）
|
Not recorded | MG MAGNESIUM ION × 326 ZN ZINC ION × 5 MVM N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å |
| 6OM0 Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs Deposited 2019-04-17 | Assembly 1 Protein–RNA Heteromer；Protein × 76 PDB declaration: 83-meric（83） Consistent with all polymers |
Chain y
9–34（26 aa）
|
Not recorded | MG MAGNESIUM ION × 31 ZN ZINC ION × 6 MVM N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 6OM7 Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs Deposited 2019-04-18 | Assembly 1 Protein–RNA Heteromer；Protein × 76 PDB declaration: 83-meric（83） Consistent with all polymers |
Chain y
9–34（26 aa）
|
Not recorded | ZN ZINC ION × 6 MG MAGNESIUM ION × 31 MVM N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
| 6U26 PCSK9 in complex with compound 16 Deposited 2019-08-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
31–692（662 aa）
|
Mutation：V474I, G670E | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；100 mM Tris (pH 7.8) 200 mM NaCl, 15% PEG 3350,
|
Resolution 1.53 Å R-free 0.213 |
| 6U26 PCSK9 in complex with compound 16 Deposited 2019-08-19 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
31–692（662 aa）
|
Mutation：V474I, G670E | 063 4'-{[(1R)-6-{2-[2-({N~5~-[N,N'-bis(tert-butoxycarbonyl)carbamimidoyl]-N~2~-(tert-butoxycarbonyl)-L-ornithyl}amino)ethoxy]ethoxy}-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}-2'-fluoro[1,1'-biphenyl]-4-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；100 mM Tris (pH 7.8) 200 mM NaCl, 15% PEG 3350,
|
Resolution 1.53 Å R-free 0.213 |
| 6U2F PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2 Deposited 2019-08-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–692（692 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；4 M ammonium acetate, 0.1 M Tris, pH 8.5, 3% v/v 1,8 diaminooctane
|
Resolution 2.94 Å R-free 0.209 |
| 6U2N PCSK9 in complex with compound 4 Deposited 2019-08-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
31–692（662 aa）
Chain B
31–692（662 aa）
|
Not recorded | PV7 4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；303 K；(10-22)% PEG 10000, 0.1M Tris, pH 8.5, 10% Ethylene Glycol, 1% BAM
|
Resolution 2.15 Å R-free 0.234 |
| 6U2P PCSK9 in complex with compound 5 Deposited 2019-08-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
31–692（662 aa）
Chain B
31–692（662 aa）
|
Mutation：V474I, G670E Mutation：V474I, G670E | EDO 1,2-ETHANEDIOL × 5 PUV 2-fluoro-4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；303 K；(10-22)% PEG 10000, 0.1M Tris, pH 8.5, 10% Ethylene Glycol, 1% BAM
|
Resolution 2.04 Å R-free 0.216 |
| 6U36 PCSK9 in complex with a Fab and compound 14 Deposited 2019-08-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
31–692（662 aa）
Chain B
31–692（662 aa）
|
Mutation：V474I, G670E Mutation：V474I, G670E | PVM 2-fluoro-4-{[(1R)-6-(2-{4-[1-(4-methoxyphenyl)-5-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-1H-1,2,3-triazol-1-yl}ethoxy)-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；0.1M Bicine pH9.0, 2% dioxane, 10% PEG 20000
|
Resolution 2.70 Å R-free 0.251 |
| 6U38 PCSK9 in complex with a Fab and compound 8 Deposited 2019-08-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
31–692（662 aa）
Chain B
31–692（662 aa）
|
Mutation：V474I, G670E Mutation：V474I, G670E | PVJ 2-fluoro-4-{[(1R)-1-methyl-6-{[(2S)-oxan-2-yl]methoxy}-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；0.1M Bicine pH9.0, 2% dioxane, 10% PEG 20000
|
Resolution 2.73 Å R-free 0.243 |
| 6U3I Design of organo-peptides as bipartite PCSK9 antagonists Deposited 2019-08-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
1–692（692 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；4 M ammonium acetate, 0.1 M Tris, pH 8.5, 3% v/v 1,8 diaminooctane
|
Resolution 2.90 Å R-free 0.217 |
| 6U3X PCSK9 in complex with compound 2 Deposited 2019-08-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
31–692（662 aa）
Chain B
31–692（662 aa）
|
Mutation：V474I, G670E Mutation：V474I, G670E | PVV 2-[(1R)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]-N-(1,3-thiazol-2-yl)acetamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；303 K；10-22% PEG 10K, 0.1M Tris, pH 8.5, 10% ethylene glycol, 1% BAM
|
Resolution 2.64 Å R-free 0.284 |
| 6XIB PCSK9(deltaCRD) in complex with cyclic peptide 30 Deposited 2020-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 1.55 Å R-free 0.205 |
| 6XIC PCSK9(deltaCRD) in complex with cyclic peptide 40 Deposited 2020-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
32–152（121 aa）
Chain B
153–452（300 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 1.38 Å R-free 0.221 |
| 6XID PCSK9(deltaCRD) in complex with cyclic peptide 51 Deposited 2020-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 1.48 Å R-free 0.205 |
| 6XIE PCSK9(deltaCRD) in complex with cyclic peptide 77 Deposited 2020-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 1.43 Å R-free 0.221 |
| 6XIF PCSK9(deltaCRD) in complex with cyclic peptide 83 Deposited 2020-06-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 1.77 Å R-free 0.204 |
| 7ANQ Complete PCSK9 C-ter domain in complex with VHH P1.40 Deposited 2020-10-12 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
452–682（231 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Protein: Purified PCSK9/P1.40 complex at 5.3 mg/ml Precipitant: 10% PEG 4.000, 0.2M imidazole malate, pH 7.0 Cryoprotectant: 40% SM3 (25 % diethylene glycol + 25 % ethylene glycol + 25 % glycerol + 25 % 1,4-dioxane) 25% PEG 4.000, 0.2M imidazole malate, pH 7.0
|
Resolution 2.20 Å R-free 0.256 |
| 7KEV PCSK9 in complex with a cyclic peptide LDLR disruptor Deposited 2020-10-12 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
29–152（124 aa）
Chain B
153–692（540 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；20.0% PEG-6000, 0.1M TRIS
|
Resolution 2.80 Å R-free 0.280 |
| 7KFA PCSK9 in complex with PCSK9i a 13mer cyclic peptide LDLR disruptor Deposited 2020-10-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
29–152（124 aa）
Chain B
153–692（540 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；20.0% PEG-6000, 0.1M TRIS
|
Resolution 2.45 Å R-free 0.242 |
| 7S5G PCSK9 in complex with compound 19 Deposited 2021-09-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | GOL GLYCEROL × 1 89N (2E)-but-2-ene-1,4-diol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 2.04 Å R-free 0.286 |
| 7S5H PCSK9(deltaCRD) in complex with cyclic peptide 35 Deposited 2021-09-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–452（300 aa）
|
Not recorded | 89N (2E)-but-2-ene-1,4-diol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；291 K；20% PEG3350, 200mM CaCl2, 100mM MES pH 6
|
Resolution 1.27 Å R-free 0.209 |
| 8FPO PCSK9 in complex with an inhibitor Deposited 2023-01-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl (pH 8.0), 14-19% PEG 6000
|
Resolution 3.00 Å R-free 0.250 |
| 8FPQ PCSK9 in complex with an inhibitor Deposited 2023-01-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
61–152（92 aa）
Chain B
153–682（530 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 2.50 Å R-free 0.234 |
| 8FVL PCSK9 in complex with an inhibitor Deposited 2023-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 1.96 Å R-free 0.218 |
| 8FVM PCSK9 in complex with an inhibitor Deposited 2023-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Chain B
153–692（540 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 2.85 Å R-free 0.238 |
| 8FVN PCSK9 in complex with an inhibitor Deposited 2023-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 2.71 Å R-free 0.257 |
| 8FVO PCSK9 in complex with an inhibitor Deposited 2023-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 2.65 Å R-free 0.239 |
| 8FVP PCSK9 in complex with an inhibitor Deposited 2023-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 2.60 Å R-free 0.215 |
| 8FVQ PCSK9 in complex with an inhibitor Deposited 2023-01-19 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–152（152 aa）
Fragment：prodomain residues 1-152
Chain B
153–692（540 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 2.57 Å R-free 0.260 |
| 8VDV pcsk9 in complex with inhibitor Deposited 2023-12-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
61–152（92 aa）
Fragment：PRODOMAIN, UNP RESIDUES 1-152
Chain B
153–681（529 aa）
Fragment：UNP RESIDUES 153-692
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；298 K；20.0% Peg-6000, 0.1M Tris pH8.0
|
Resolution 1.97 Å R-free 0.217 |
| 8WFR The Crystal Structure of PCSK9 from Biortus. Deposited 2023-09-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
31–152（122 aa）
Chain B
153–692（540 aa）
|
Not recorded | EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 EDO 1,2-ETHANEDIOL × 2 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.1M HEPES pH7.5, 20% PEG 10000
|
Resolution 1.95 Å R-free 0.203 |
| 9HZ3 PCSK9 AZD0780 complex Deposited 2025-01-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–152（152 aa）
Chain B
153–692（540 aa）
|
Not recorded | A1IYR 1-[6-[[(1~{S},3~{S})-3-[[5-[bis(fluoranyl)methoxy]pyrimidin-2-yl]amino]cyclopentyl]amino]pyridin-3-yl]pyridin-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；25 mM HEPES pH 7.5 300 mM NaCl 5% glycerol
|
Resolution 1.43 Å R-free 0.213 |
| 9SZY PCSK9 CTD fragment structure Deposited 2025-10-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–152（152 aa）
Chain B
1–692（692 aa）
|
Not recorded | A1JSM ~{N}-(2-methylpropyl)pyrimidin-2-amine × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；25 mM HEPES pH 7.5 300 mM NaCl 5% glycerol
|
Resolution 1.76 Å R-free 0.236 |